Third degree atrioventricular block associated with treatment with rivastigmine transdermal patch  

作　　者：Fredrikke C. Knudtzen Thomas B. Christophersen 

机构地区：[1]Department of Internal Medicine, OUH Svendborg Hospital, Valdemarsgade 53, 5700 Svendborg, Denmark

出　　处：《Journal of Geriatric Cardiology》2013年第1期113-115,共3页老年心脏病学杂志（英文版）

摘　　要：Rivastigmine transdermal patch is indicated for patientswithAlzheimer’s disease and dementia with Parkinson’s disease. Rivastigmine, an acetylcholinesterase inhibitor, has several common adverse effects, mainly involving the gastrointestinal tract, but few cardiovascular adverse effects have been reported. This report presents two cases of patients presenting with 3rd degree atrioventricular block. Both patients were treated with the acetylcholinesterase inhibitor, rivastigmine. In one case, the patient reverted to normal sinus rhythm following the discontinuation of rivastigmine, and the atrioventricular block reappeared after rivastigmine was reinstated. In the other case, the atrioventricular block did not revert and the patient required a permanent pacemaker. Both bradycardia and syncope have previously been reported as adverse events in patients treated with acetylcholinesterase inhibitors. However, the type of bradycardia and the etiology of the syncope are rarely specified. Rivastigmine, and other acetylcholinesterase inhibitors, are widely used in the pharmacological treatment of Alzheimer��s disease. We recommend that physicians are vigilant of possible warning signs, such as dizziness, syncope and bradycardia.

分 类 号：R[医药卫生]