GENISTEIN

作品数:311被引量:836H指数:13
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相关领域:医药卫生更多>>
相关作者:李昱米粲张继红倪衡建刘丹更多>>
相关机构:南京医科大学中国医科大学第三军医大学河北医科大学更多>>
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相关基金:国家自然科学基金中国博士后科学基金重庆市科学技术委员会院士基金辽宁省自然科学基金更多>>
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Genistein:a possible solution for the treatment of Alzheimer’s disease
《Neural Regeneration Research》2025年第10期2903-2905,共3页Karolina Pierzynowska Bartosz Karaszewski Grzegorz Węgrzyn 
supported by Fundacja ORLEN(donation No.161/XI/2022)(to GW).
Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous tissue.They can lead to...
关键词:ORGANS ALZHEIMER DEATH 
Preparation,physicochemical properties and antioxidant activity of genistein phospholipid complexes
《Journal of Polyphenols》2024年第4期141-149,共9页Ming Yang Dan Zhang Honghui Zhao Shuping Wang Xu Zhao 
Genistein phospholipid complex(GS-PC)was produced in order to increase the solubility and antioxidant activity of genistein(GS),an insoluble natural polyphenol compound.By using the solvent evaporation process,GS-PC w...
关键词:GENISTEIN phospholipid complex physical and chemical properties ANTIOXIDANT 
Effect of Maternal DEHP Exposure on Lipid Metabolism in Adult Male Rats and the Antagonistic Effect of Genistein被引量:1
《Biomedical and Environmental Sciences》2024年第3期315-319,共5页ZHANG Yun Bo LI Jiang Li TIAN Jie NA Xiao Lin 
supported by the Natural Science Foundation of Heilongjiang Province[LH2021H011].
Lipid metabolism refers to the biochemical processes involved in synthesising,storing,utilising,and breaking down lipids in living organisms.Lipids are essential for various physiological functions,including energy st...
关键词:LIPID metabolism ORGANS 
PRF负载的Genistein促进肥胖小鼠骨缺损修复的实验研究
《上海口腔医学》2024年第1期13-21,共9页张雪冰 李琦 
内蒙古自然科学基金(2020MS08036)。
目的:明确染料木素(genistein, GEN)对成骨分化的作用并探讨由富血小板纤维蛋白(platelet-rich fibrin,PRF)负载的GEN对肥胖小鼠骨缺损修复过程的影响。方法:体外实验中,采用CCK8测定7天内不同浓度GEN(0、0.1、1、10、50μmol/L)对小鼠...
关键词:染料木素 肥胖 骨缺损 小鼠 
A highly selective cell-based fluorescent biosensor for genistein detection被引量:2
《Engineering Microbiology》2023年第2期72-82,共11页Lucy Fang-I Chao Dany Liu Verena Siewers 
The authors thank the Sadowski laboratory for sharing pIOX179.This project received funding from the European Union’s Horizon 2020 re-search and innovation program under grant agreement no.814650.
Genistein,an isoflavone found mainly in legumes,has been shown to have numerous health benefits for hu-mans.Therefore,there is substantial interest in producing it using microbial cell factories.To aid in screening fo...
关键词:BIOSENSOR GENISTEIN Flavonoid ISOFLAVONE 
Optimized solubility and bioavailability of genistein based on cocrystal engineering
《Natural Products and Bioprospecting》2023年第1期450-463,共14页Zhipeng Wang Qi Li Qi An Lixiang Gong Shiying Yang Baoxi Zhang Bin Su Dezhi Yang Li Zhang Yang Lu Guanhua Du 
the National Natural Science Foundation of China(Grant No.22278443);CAMS Innovation Fund for Medical Sciences(Grant No.2022-I2M-1-015);the Chinese Pharmacopoeia Commission Drug Standard Promoting Fund(Grant No.2023Y11)for financial support.
With various potential health-promoting bioactivities,genistein has great prospects in treatment of a series of complex diseases and metabolic syndromes such as cancer,diabetes,cardiovascular diseases,menopausal sympt...
关键词:GENISTEIN PIPERAZINE COCRYSTAL SOLUBILITY BIOAVAILABILITY 
Reducing systemic absorption and macrophages clearance of genistein by lipid-coated nanocrystals for pulmonary delivery被引量:1
《Chinese Chemical Letters》2023年第1期245-250,共6页Yuan He Chang Liu Run Han Yingmin Liang Judith Choi Wo Mak Yinghao Zhu Haifeng Li Ying Zheng 
supported by the Multi-Year Research Grants from the University of Macao(No.MYRG2019–00032-ICMS);Natural Science Foundation of Jiangsu Province(No.BK20210912);the startup grant of Xuzhou Medical University(D2021004);Macao Science and Technology Development Fund(No.0017/2019/AKP)。
Pulmonary delivery is an effective drug delivery strategy for the treatment of local respiratory diseases.However,the rapid systemic absorption through the lung due to the thin barrier and persistent lung clearances i...
关键词:Pulmonary delivery Lipid-coated nanocrystals Cell uptake Transport Systemic absorption Macrophage clearances 
A novel derivative of Genistein inhibits proliferation of ovarian cancer HO-8910 cells by regulating reactive oxygen species
《Oncology and Translational Medicine》2022年第6期285-292,共8页Yanping Gao Zhiyong Dong Jun Bai 
Supported by a grant from the Scientific Research Project of Shanxi Provincial Health Commission(No.2021166)。
Objective To investigate the anticancer effect of a novel derivative of genistein(5-hydroxy-4’-nitro-7-propionyloxy-genistein,HNPG)on human ovarian cancer HO-8910 cells and its possible molecular mechanism.Methods HO...
关键词:ovarian cancer 5-hydroxy-4’-nitro-7-propionyloxy-genistein reactive oxygen species PROLIFERATION apoptosis 
Quality Standard of Yi Herb Medicine Millettia dielsiana
《Medicinal Plant》2022年第5期26-30,共5页Maliniu SHA Wenbing LI Dongmei SHA Meiyi TONG Jing WANG Xinjia YAN Yuan LIU 
Supported by National Key Research and Development Program of China(2018YFC1706101);Science and Technology Program of Sichuan Province(Key Research and Development Project)(2021YFS0043);Standard Improvement of Traditional Chinese Medicine(Ethnic Medicine)of Sichuan Provincial Drug Administration(510201202102305);2022 Leading Talents Support Program of National Ethnic Affairs Commission;University-level Innovation Team Special Project of Basic Research Funds for Central Universities and Colleges(ZYN2022067)。
[Objectives]The paper was to establish the quality standard of Yi herb medicine Millettia dielsiana.[Methods]Yi herb medicine M.dielsiana was qualitatively identified by microscopic identification and thin layer ident...
关键词:Yi herb medicine Millettia dielsiana GENISTEIN TLC UV-Vis spectrophotometry 
Genistein Mitigates the Gastro-Toxic Effects of Bisphenol A in Male Wistar Rats被引量:1
《Journal of Biosciences and Medicines》2022年第9期60-78,共19页Abayomi Oluwatosin Ige Olayinka Oyinkansola Adebayo Bernard Omokheshi Adele Anthony Olusoji Odetola Idara Emmanuel Emediong Elsie Olufunke Adewoye 
Exposure to Bisphenol A (BPA) worldwide is on the increase. Its toxicities in various tissues expressing estrogen receptors have been reported. However, limited information exists on its effects on the gastric tissue....
关键词:Bisphenol A GENISTEIN STOMACH Gastro-Protection Gastric Impairment 
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