OZAGREL

作品数:8被引量:9H指数:2
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相关领域:医药卫生更多>>
相关机构:空军军医大学(第四军医大学)沈阳药科大学更多>>
相关期刊:《Chinese Journal of Structural Chemistry》《Journal of Hainan Medical University》《Acta Pharmacologica Sinica》《中国合理用药探索》更多>>
相关基金:国家自然科学基金辽宁省教育厅自然科学基金更多>>
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奥扎格雷(ozagrel)
《中国合理用药探索》2022年第1期26-26,共1页
(一)适应症急性血栓性脑梗死和脑梗死所伴随的运动障碍。(二)用法用量成人一次40~80mg,每日1~2次,溶于500ml 0.9%氯化钠注射液或5%葡萄糖注射液中,连续静脉滴注,2周为一疗程。(三)不良反应胃肠道反应和过敏反应,如恶心、呕吐、荨麻疹、...
关键词:血栓溶解剂 深度昏迷 心律不齐 连续静脉滴注 皮下出血 严重高血压 抗凝药 药物相互作用 
Characteristics of β-oxidative and reductive metabolism on the acyl side chain of cinnamic acid and its analogues in rats被引量:3
《Acta Pharmacologica Sinica》2019年第8期1106-1118,共13页Kai-jing Zhao Yang Chen Shi-jin Hong Yi-ting Yang Jiong Xu Han-yu Yang Liang Zhu Ming Liu Qiu-shi Xie Xian-ge Tang Ting-ting Yang Ya-qian Zhou Li Liu Xiao-dong Liu 
supported by the National Natural Science Foundation of China (No. 81573490, 81872930, 81473273 and 81673505);Natural Science Foundation of Jiangsu Province of China (BK20161457);the "333", "Six Talent Peaks" and "Cyan Blue" Projects of Jiangsu Province
Cinnamic acid and its analogues (pyragrel and ozagrel) undergo chain-shortened (β-oxidative) and reductive metabolism on acyl side chain. In this study, we characterized the β-oxidative and reductive metabolism on a...
关键词:ANTIPLATELET DRUG cinnamic acid pyragrel OZAGREL DRUG METABOLISM hepatocytes mitochondria MICROSOMES pharmacokinetics in vitro-in vivo correlation 
Effect of danhong injection combined with sodium ozagrel on serum IL-8, TNF-α, VEGF, TBIL and NSE in old patients with acute cerebral infarction
《Journal of Hainan Medical University》2017年第17期130-133,共4页Ling Li Yan Zhang 
Objective:To study the effect of danhong injection combined with sodium ozagrel on serum IL-8, TNF-α, VEGF, TBIL and NSE in old patients with acute cerebral infarction.Methods:A total of 100 old patients with acute c...
关键词:DANHONG injection Sodium OZAGREL Acute cerebral infarction IL-8 TNF-Α VEGF TBIL NSE 
Observation on the therapeutic effect of aspirin in combined with ozagrel sodium in the treatment of acute cerebral infarction被引量:1
《Journal of Hainan Medical University》2017年第4期141-144,共4页Wu-Cheng Ye Jun-Xia Wang Peng Ye Bo He 
Objective:To evaluate the changes in serum index levels after monosialoganglioside injection combined with conventional treatment of neonatal hypoxic ischemic encephalopathy. Methods:A total of 70 children with neonat...
关键词:NEONATAL HYPOXIC ischemic ENCEPHALOPATHY MONOSIALOGANGLIOSIDE Apoptosis Oxidative stress 
Observation on the therapeutic effect of aspirin in combined with ozagrel sodium in the treatment of acute cerebral infarction被引量:1
《Journal of Hainan Medical University》2017年第1期41-44,共4页Hong-Jing Shen Hai-Yan He Ming-Xuan Dai 
Objective:To explore the clinical efficacy of aspirin in combined with ozagrel sodium in the treatment of acute cerebral infarction (ACI).Methods:A total of 120 patients with ACI who were admitted in our hospital from...
关键词:Essential HYPERTENSION ECG Cornell voltage LEFT VENTRICLE HYPERTROPHY 
Synthesis and Crystal Structure of a Three-dimensional Cobalt Coordination Polymer Assembled by Ozagrel Ligands
《Chinese Journal of Structural Chemistry》2015年第1期117-122,共6页聂旭亮 胡春燕 黄长干 上官新晨 
supported by the National Natural Foundation of China(No.31060213);the Research Foundation of Educational Department of Jiangxi Province(No.GJJ13261)
A three-dimensional cobalt coordination polymer [Co(IMPAA)2]n(1, HIMPAA =(2E)-3-[4-(1H-imidazol-1-ylmethyl)phenyl]acrylic acid) was synthesized with ozagrel and structurally characterized by element analysis, ...
关键词:coordination polymer crystal structure OZAGREL Co(II) TGA properties 
Preparation of ozagrel-magnetoliposomes and investigation on the release in vitro under AC-magnetic field
《渤海大学学报(自然科学版)》2010年第3期213-218,共6页刘彬 王君 
国家自然科学基金项目(No:20371023);辽宁省教育厅自然科学基金资助项目(No:2008247)~~
To reduce the first-pass effect and increase the targeting of ozagrel(OZ),the ozagrel -magnetoliposomes(OZ-MLs)were prepared in this study.Here,we described the preparation and characterization of OZ-MLs.It had a diam...
关键词:摘要 编辑部 编辑工作 读者 
An Improved and Convenient Procedure for the Synthesis of Ozagrel被引量:4
《Chinese Chemical Letters》2006年第2期180-182,共3页Chun GUO Xiao Dan LIU Zhen Gang XIE Chu Jun LI 
A novel approach to the synthesis of ozagrel is described. The target compound is conveniently prepared from the commercially available material, 1,1-carboxyldiimidazole (CDI) through the condensation and hydrolyzat...
关键词:OZAGREL SYNTHESIS 1 1-carboxyldiimidazole. 
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