PLUMBAGIN

作品数：20被引量：66H指数：5
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相关领域：医药卫生更多>>
相关作者：祖玲玲于涛王伟强李永文刘刚更多>>
相关机构：天津医科大学总医院上海交通大学广西师范大学新乡医学院第三附属医院更多>>
相关期刊：《Medicinal Plant》《肿瘤研究与临床》《Acta Pharmacologica Sinica》《Journal of Hainan Medical University》更多>>
相关基金：国家自然科学基金泰国研究基金中国博士后科学基金广西壮族自治区自然科学基金更多>>
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Preparation Process of Plumbagin Nanomicelle In-situ Gel
《Medicinal Plant》2023年第6期35-38,42,共5页Xuemei LU Wanyu ZUO Yun LI Weiyu WANG Ruyin DONG Luyang LU Jizhong ZHANG 
Supported by Special Fund for Basic Scientific Research Business in Central Universities(2019NYB31);Scientific Research Funded Project of Southwest Minzu University(2023KYZZ06N).
[Objectives]To prepare plumbagin nanomicelle(PLB-N)in-situ gel,and optimize the formulation and process.[Methods]PLB-N was prepared by self-assembly method,and the optimal formulation of PLB-N in-situ gel was determin...
关键词：PLUMBAGIN Nanomicelle In-situ gel Preparation process 
Research Progress and Ideas on the Anti-liver Fibrosis Effect of Ethnic Medicine Plumbagin Based on microRNAs/TLR4/NF-κB and NLRP3 Inflammasome Activation
《Medicinal Plant》2023年第5期110-114,共5页Mingzhe LU Qianyu LIU Yue PENG Jiang LIN Weiqian GUO Miao YANG 
Supported by the National Natural Science Foundation of China(81960761,82060825);Guangxi Natural Science Foundation(2020GXNSFAA297119);Traditional Chinese Medicine,a First-class Discipline in Guangxi(GUIJIAOKEYAN[2022]1);Guangxi Famous Traditional Chinese Medicine Linjiang Inheritance Studio(GUIZHONGYIYAOKEJIAOFA[2021]6);Guangxi Graduate Education Innovation Program Project(YCSY2023004,YCSZ2022002);Key Laboratory Project of Integrated Traditional Chinese and Western Medicine Translational Medicine of Guangxi High-incidence Infectious Diseases.
The core of hepatic fibrosis is the activation of hepatic stellate cells.Through the lipopolysaccharide/TLR4/MyD88/NF-κB signal transduction pathway,the inflammatory response in the liver is directly enhanced,and the...
关键词：PLUMBAGIN Anti-liver fibrosis Hepatic stellate cells TLR4 MICRORNAS NLRP3 inflammasome 
Effects of plumbagin on migration and invasion of human hepatoma cell line via JAK2/STAT3 signaling pathway
《Journal of Hainan Medical University》2023年第1期33-41,共9页CHENG Tao WEI Yan-fei LIU Huan LIU Hong DENG Shu-ye 
Program of Guangxi Natural Science Foundation(No.2019GXNSDA 245003);The second batch of"Qihuang Project"high-level talent team cultivation project of Guangxi University of Traditional Chinese Medicine(No.2021001);Doctoral Research Initiation Fund of Guangxi University of Traditional Chinese Medicine(2020BS027);2021 Guangxi Postgraduate Innovation Project(No.YCXJ2021007)。
Objective:To study the effect of plumbagin(PL)on the migration and invasion of human hepatocellular carcinoma(HCC)cells and its possible mechanism.Methods:The cell counting kit(CCK-8)was used to detect the effects of ...
关键词：PLUMBAGIN Hepatic carcinoma JAK2/STAT3 signaling pathway Migration INVASION 
Quality Standard of Zijinbiao
《Medicinal Plant》2022年第5期34-37,共4页Jianlong LAN Yuebu HAILAI Cijia DIJIU Hongna SU Li LI Zhengming YANG Yuan LIU 
Supported by National Key R&D Program(2018YFC1706101);Sichuan Provincial Key R&D Project(2021YFS0043);Chinese Medicine(Ethnic Medicine)Standard Improvement Project of Sichuan Medical Products Administration(510201202102305);Leading Talent Support Program of National Ethnic Affairs Commission of the People’s Republic of China in 2021;School Level Innovation Team of Fundamental Research Funds for the Central Universities(ZYN2022067)。
[Objectives]To establish the quality standard for Zijinbiao.[Methods]Microscopic identification,physical and chemical identification,and thin-layer chromatography(TLC)were used to qualitatively identify Zijinbiao.The ...
关键词：Zijinbiao PLUMBAGIN Microscopic identification Thin-layer chromatography(TLC) High performance liquid chromatography(HPLC) 
Self-assembled metal-organic frameworks nanocrystals synthesis and application for plumbagin drug delivery in acute lung injury therapy被引量：2
《Chinese Chemical Letters》2022年第1期324-327,共4页Yang Wang Qing Li Mengsheng Deng Kuijun Chen Jianmin Wang 
supported by the Open Project of the State Key Laboratory of Trauma,Burn and Combined Injury,Third Military Medical University(No.SKLKF201704);Postdoctoral Science Foundation of China(No.2018M633759)。
Metal-organic frameworks(MOFs)have recently allured a variety of concern in the fields of nanotechnology.However,exploring their biomedical applications is still a relatively new field.In this work,zeolite imidazole s...
关键词：ZIF-8 PLUMBAGIN Drug delivery Lung injury 
Research Progress and Research Ideas on Anti-hepatic Fibrosis and Promoting Blood Circulation and Removing Blood Stasis of the National Drug Plumbapin Based on W-P Body
《Plant Diseases and Pests》2020年第4期39-46,共8页Peng Yue Su Aolei Zhao Tiejian Zheng Yang Shang Zhihao 
Supported by the Research Project of National Natural Science Foundation of China(No.81960761,81960751,81680705);Basic Ability Improvement Project for Young and Middle-aged Teachers in Colleges and Universities of Guangxi(No.2018KY1149)。
Hepatic sinusoidal endothelial cells(HSEC)are the most important cells that constitute the microcirculation barrier of liver.Clinically,W-P bodies have been detected in the HSEC cells of most patients with liver fibro...
关键词：PLUMBAGIN Anti-hepatic fibrosis Promoting circulation and removing stasis Liver sinusoidal endothelial cell W-P body Animal moulding 
Author Correction:Plumbagin attenuates cancer cell growth and osteoclast formation in the bone microenvironment of mice
《Acta Pharmacologica Sinica》2020年第4期581-582,共2页Wei Yan Ting-yu Wang Qi-ming Fan Lin Du Jia-ke Xu Zan-jing Zhai Hao-wei Li Ting-ting Tang 
During re-read of our previous article Plumbagin attenuates cancer cell growth and osteoclast formation in the bone microenvironment of mice published in Acta Pharmacologica Sinica,we were regretted to point out a mis...
关键词：CANCER CORRECTION CONCLUSION 
Inhibitory activities of plumbagin on cell migration and invasion and inducing activity on cholangiocarcinoma cell apoptosis被引量：1
《Asian Pacific Journal of Tropical Medicine》2018年第7期430-435,共6页Luxsana Panrit Tullayakorn Plengsuriyakarn Pongsakorn Martviset Kesara Na-Bangchang 
supported by Thammasat University research grant(Grant No.20/2556:Ms.Luxana Panrit);Thammasat University Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma;The Commission of Higher Education,Ministry of Education of Thailand(National University Project);National Research Council of Thailand
Objective: To investigate the cytotoxic, apoptotic and inhibitory activities on cell migration and invasion of plumbagin in the human cholangiocarcinoma(CCA) cell line(CL-6) in comparison with human embryonic fibrobla...
关键词：CHOLANGIOCARCINOMA PLUMBAGIN Cancer migration Cancer invasion Apoptosis 
Plumbagin suppresses chronic periodontitis in rats via down-regulation of TNF-α, IL-1β and IL-6 expression被引量：27
《Acta Pharmacologica Sinica》2017年第8期1150-1160,共11页Xin-yi ZHENG Chuan-yuan MAO Han QIAO Xi ZHANG Li YU Ting-yu WANG Er-yi LU 
This work was supported by grants from the National Natu- ral Science Foundation of China （No 81570948）, Science and Technology Commission of Shanghai Municipality （No 17140903400） and the Opening Project of Shanghai Key Labo- ratory of Orthopaedic Implant （No KFKT2015002）.
Chronic periodontitis （CP） is one of the most common oral diseases, which causes alveolar bone absorption and tooth loss in adults. in this study we aimed to investigate the potential of plumbagin （PL）, a widely-i...
关键词：PLUMBAGIN traditional Chinese herb chronic periodontitis periodontal ligament stem cells TNF-Α IL-1Β IL-6 MAPK NF-κB JAK/STAT 
Inhibitory effect of plumbagin,a potential anticancer natural compound,on cytochrome P450 2J2 in humans
《中国药理学与毒理学杂志》2016年第10期1044-1044,共1页LU Jian LIU Dao-zhi ZHOU Xiao-jing CHEN Ang LIU Ming-yao WANG Xin 
The project supported by National Natural Science Foundation of China(81301908);the Science and Technology Commission of Shanghai Municipality(15140904700,13ZR1412600 and 14DZ2270100)
OBJECTIVE Cytochrome P450(CYP)2J2 is highly expressed in many kinds of human tumors and promotes tumor cell growth via regulating the metabolism of arachidonic acids.The purposes of this study were toidentify the new ...
关键词：PLUMBAGIN astemizole CYP2J2 ANTITUMOR LC-MS/MS CYTOTOXICITY 
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