Preparation Process of Plumbagin Nanomicelle In-situ Gel  

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作  者:Xuemei LU Wanyu ZUO Yun LI Weiyu WANG Ruyin DONG Luyang LU Jizhong ZHANG 

机构地区:[1]College of Pharmacy,Southwest Minzu University,Chengdu 610041,China [2]University of Tibetan Medicine,Lhasa,850000,China

出  处:《Medicinal Plant》2023年第6期35-38,42,共5页药用植物:英文版

基  金:Supported by Special Fund for Basic Scientific Research Business in Central Universities(2019NYB31);Scientific Research Funded Project of Southwest Minzu University(2023KYZZ06N).

摘  要:[Objectives]To prepare plumbagin nanomicelle(PLB-N)in-situ gel,and optimize the formulation and process.[Methods]PLB-N was prepared by self-assembly method,and the optimal formulation of PLB-N in-situ gel was determined by orthogonal experiment design and single factor method.[Results]The optimal preparation process for PLB-N was a drug to lipid ratio of 1:3,a Tween 80 content of 5%,an ethanol content of 7.5%of the hydration medium,a magnetic stirring speed of 2200 rpm,a stirring time of 30 min,and an ultrasound time of 10 min.The optimal formulation of PLB-N in-situ gel was 22%of poloxamer 407,6%of poloxamer 188,and 1:1 of PLB-N to water.The encapsulation efficiency of PLB-N prepared with the optimal formula was(95.8%±0.4%),and the average particle size was(75.19±1.14)nm,and the Zeta potential was(-20.73±1.19)mv.[Conclusions]PLB-N in-situ gel had stable and reliable preparation process,uniform content,and broad application prospects.

关 键 词:PLUMBAGIN Nanomicelle In-situ gel Preparation process 

分 类 号:R285[医药卫生—中药学]

 

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