Research Progress and Research Ideas on Anti-hepatic Fibrosis and Promoting Blood Circulation and Removing Blood Stasis of the National Drug Plumbapin Based on W-P Body  

作　　者：Peng Yue Su Aolei Zhao Tiejian Zheng Yang Shang Zhihao 

机构地区：[1]Guangxi University of Chinese Medicine,Nanning 530200,China [2]Medical Basic Department of Guangxi Medical College,Nanning 530021,China

出　　处：《Plant Diseases and Pests》2020年第4期39-46,共8页植物病虫害研究（英文版）

基　　金：Supported by the Research Project of National Natural Science Foundation of China(No.81960761,81960751,81680705);Basic Ability Improvement Project for Young and Middle-aged Teachers in Colleges and Universities of Guangxi(No.2018KY1149)。

摘　　要：Hepatic sinusoidal endothelial cells(HSEC)are the most important cells that constitute the microcirculation barrier of liver.Clinically,W-P bodies have been detected in the HSEC cells of most patients with liver fibrosis,and these bodies have become the synthesis and storage sites of vW factor,ET-1 and other factors of liver fibrosis;during pathological stimulation,W-P bodies will excrete the above factors into the cytoplasm,which can make the structure and function of HSEC maladjusted,cause the disturbance of liver microcirculation,and aggravate the process of liver fibrosis.However,previous studies have found that Plumbagin,the active ingredient of Guangxi specialty ethnic medicine,has the definite function of promoting blood circulation and removing blood stasis and anti-liver fibrosis,but its mechanism is not clear.In this study,the research progress of the above problems was reviewed,and further research ideas were derived from it as follows:the role of Plumbagin in promoting blood circulation and removing blood stasis and anti-liver fibrosis is produced by affecting the formation quantity of W-P bodies,affecting the synthesis and storage of the contents of W-P bodies,and interfering with their exocytosis ability.

关 键 词：PLUMBAGIN Anti-hepatic fibrosis Promoting circulation and removing stasis Liver sinusoidal endothelial cell W-P body Animal moulding 

分 类 号：R285[医药卫生—中药学]