Research Progress and Ideas on the Anti-liver Fibrosis Effect of Ethnic Medicine Plumbagin Based on microRNAs/TLR4/NF-κB and NLRP3 Inflammasome Activation  

作　　者：Mingzhe LU Qianyu LIU Yue PENG Jiang LIN Weiqian GUO Miao YANG 

机构地区：[1]School of Graduate,Guangxi University of Chinese Medicine,Nanning 530200,China [2]School of Basic Medicine,Guangxi University of Chinese Medicine,Nanning 530200,China

出　　处：《Medicinal Plant》2023年第5期110-114,共5页药用植物：英文版

基　　金：Supported by the National Natural Science Foundation of China(81960761,82060825);Guangxi Natural Science Foundation(2020GXNSFAA297119);Traditional Chinese Medicine,a First-class Discipline in Guangxi(GUIJIAOKEYAN[2022]1);Guangxi Famous Traditional Chinese Medicine Linjiang Inheritance Studio(GUIZHONGYIYAOKEJIAOFA[2021]6);Guangxi Graduate Education Innovation Program Project(YCSY2023004,YCSZ2022002);Key Laboratory Project of Integrated Traditional Chinese and Western Medicine Translational Medicine of Guangxi High-incidence Infectious Diseases.

摘　　要：The core of hepatic fibrosis is the activation of hepatic stellate cells.Through the lipopolysaccharide/TLR4/MyD88/NF-κB signal transduction pathway,the inflammatory response in the liver is directly enhanced,and then returns to promote the activation of hepatic stellate cells.And TLR4/MyD88/NF-κB signaling pathway can directly regulate the activation of NLRP3 inflammasome and is an important pathway for activating hepatic stellate cells.TLR4/MyD88/NF-κB/NLRP3 inflammasome pathway is regulated by upstream microRNAs.These miRNAs can significantly regulate the inflammatory response of the liver and the activation behavior of hepatic stellate cells,affecting the formation of liver fibrosis.Previous studies have found that the active ingredient of Guangxi specialty ethnic medicine,plumbagin,has a definite anti liver fibrosis effect,but its mechanism of action is not clear.This paper provides a review of the research progress on the above issues,and further research ideas have been derived from this,stating that"the anti liver fibrosis effect of plumbagin is achieved by regulating miRNA/TLR4/MyD88/NF-κB inflammatory pathway and activating downstream NLRP3 inflammasome".

关 键 词：PLUMBAGIN Anti-liver fibrosis Hepatic stellate cells TLR4 MICRORNAS NLRP3 inflammasome 

分 类 号：R285.5[医药卫生—中药学]