Self-assembled metal-organic frameworks nanocrystals synthesis and application for plumbagin drug delivery in acute lung injury therapy  

作　　者：Yang Wang Qing Li Mengsheng Deng Kuijun Chen Jianmin Wang 

机构地区：[1]State Key Laboratory of Trauma,Burns and Combined Injury,Department of Surgical Research,Daping Hospital,Army Medical University,Chongqing 400042,China [2]School of Chemistry and Chemical Engineering,Yangzhou University,Yangzhou 225002,China

出　　处：《Chinese Chemical Letters》2022年第1期324-327,共4页中国化学快报（英文版）

基　　金：supported by the Open Project of the State Key Laboratory of Trauma,Burn and Combined Injury,Third Military Medical University(No.SKLKF201704);Postdoctoral Science Foundation of China(No.2018M633759)。

摘　　要：Metal-organic frameworks(MOFs)have recently allured a variety of concern in the fields of nanotechnology.However,exploring their biomedical applications is still a relatively new field.In this work,zeolite imidazole skeleton-8(ZIF-8)was reported for the first time as a drug carrier for the treatment of lung injury.Uniform ZIF-8 nanoparticles encapsulating plumbagin(PLB)are achieved by a facile physical adsorption process.Scanning electron microscopy(SEM),powder X-ray diffraction(PXRD)and UV–vis absorption spectrum were conducted to investigate the physical properties of ZIF-8 and [e-mail] animal model,the collagen fibers deposition produced by severe lung injury is significantly decreased.The secretion of inflammatory factor TGF-βand IL-6 were efficiently dropped by the combination of plumbagin and ZIF-8.At the same time,the expressions of collagen I,α-SMA and TNF-αwere also suppressed.This strategy puts forth a promising blueprint in the application of MOF materials,especially in biomedical fields.

关 键 词：ZIF-8 PLUMBAGIN Drug delivery Lung injury 

分 类 号：TQ460.4[化学工程—制药化工] TB383.1[一般工业技术—材料科学与工程]