KINDLING

作品数:39被引量:75H指数:4
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相关领域:医药卫生更多>>
相关作者:岳旺王蕾张芳杨蓉张明升更多>>
相关机构:青岛大学山西医科大学第一军医大学中国人民解放军第一军医大学更多>>
相关期刊:《Neural Regeneration Research》《中国药理通讯》《语言教育》《Acta Pharmacologica Sinica》更多>>
相关基金:国家自然科学基金山西省自然科学基金中国博士后科学基金更多>>
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Brivaracetam and rufinamide combination increased seizure threshold and improved neurobehavioral deficits in corneal kindling model of epilepsy
《Animal Models and Experimental Medicine》2025年第2期209-221,共13页Awais Sattar Zohabia Rehman Hammad Murtaza Waseem Ashraf Tanveer Ahmad Faleh Alqahtani Imran Imran 
The authors extend their appreciation to the Distinguished Scientist Fellowship program at King Saud University,Riyadh,Saudi Arabia,for funding this work through Research Supporting Project Number RSP2024R131.
Background:Besides seizures,a myriad of overlapping neuropsychiatric and cognitive comorbidities occur in patients with epilepsy,which further debilitates their quality of life.This study provides an in-depth characte...
关键词:BRIVARACETAM corneal kindling EPILEPSY neurobehavioral analyses oxidative stress RUFINAMIDE 
Unraveling the neuroprotective effect of perampanel and lacosamide combination in the corneal kindling model for epilepsy in mice
《Animal Models and Experimental Medicine》2025年第2期222-238,共17页Saba Tehreem Azka Sabir Maryam Farooq Waseem Ashraf Faleh Alqahtani Tanveer Ahmad Imran Imran 
The authors extended their appreciation to Distinguished Scientist Fellowship program at King Saud University,Riyadh,Saudi Arabia,for funding this work through research supporting project number(RSP2024R131).
Background:Scientific evidence to guide clinicians on the use of different antiseizure drugs in combination therapy is either very limited or lacking.In this study,the impact of lacosamide and perampanel alone and in ...
关键词:behavioral studies corneal kindling LACOSAMIDE learned helplessness oxidative stress PERAMPANEL 
Sericin alleviates pentylenetetrazole kindling epilepsy and associated comorbidities via modulation of GABA-T enzyme and mitochondrial activity
《Asian Pacific Journal of Tropical Biomedicine》2023年第10期431-442,共12页Sania Grover Raj Kumar Narang Shamsher Singh 
Objective:To assess the effect of sericin against pentylenetetrazole(PTZ)kindling epilepsy and its associated comorbidities.Methods:Epilepsy was induced with PTZ at the dose of 30 mg/kg i.p.on alternative days for 25 ...
关键词:PENTYLENETETRAZOLE SERICIN GABA-T EPILEPSY ANXIETY Cognitive impairment 
Ancient Chinese Culture:Passing on the Kindling Flame
《China Book International》2023年第2期62-65,共4页Lai Xinxia 
This book presents the historical evolution of book printing in China,from knotting records to modern engraving.It is divided into two parts:the first part mainly discusses the development of paper-making and engravin...
关键词:WHILE ANCIENT PRINTING 
Pharmacokinetic, pharmacodynamic, and neurochemical investigations of lamotrigine-pentylenetetrazole kindled mice to ascertain it as a reliable model for clinical drug-resistant epilepsy被引量:4
《Animal Models and Experimental Medicine》2020年第3期245-255,共11页Sandeep Kumar Rajesh K.Goel 
Background:Pentylenetetrazole kindling has long been used for the screening of investigational antiseizure drugs.The presence of lamotrigine,at a very low dose,does not hamper kindling in mice;rather it modifies this ...
关键词:animal models drug-resistant epilepsy KINDLING LAMOTRIGINE refractory epilepsy 
Effect of adenovirus-mediated overexpression of PTEN on brain oxidative damage and neuroinflammation in a rat kindling model of epilepsy被引量:4
《Chinese Medical Journal》2019年第21期2628-2635,共8页Zhi-Sheng Wu Wen-Li Huang Shu-Jie Gong 
Background:Epilepsy is a chronic and severe neurological disorder.Phosphatase and tensin homolog deleted on chromosome ten(PTEN)-deficient mice exhibit learning and memory deficits and spontaneous epilepsy.The aim of ...
关键词:EPILEPSY Status epilepticus BRAIN injuries Oxidative stress Neurons Inflammation 
Mood Disorders: Protection of the Hyper-Excited Brain, or a Risk Factor?
《Journal of Behavioral and Brain Science》2019年第2期54-65,共12页Zakaria I. Nanobashvili Irine G. Bilanishvili Maia G. Barbakadze Nadejda A. Khizanishvili 
Emotional disturbances such as anxiety, fear, depression and aggression are often experienced by patients with temporal lobe epilepsy. These psychiatric symptoms may occur during or just after (postictal) a seizure;ho...
关键词:KINDLING HYPOTHALAMUS Stress SEIZURE Rats 
Synaptic Vesicle Protein2A Decreases in Amygdaloid-kindling Pharmcoresistant Epileptic Rats被引量:2
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2015年第5期716-722,共7页史静 周凤 王丽琨 伍国锋 
supported by grants from National Natural Science Foundation of China(No.81241129/H0913);Guizhou Province Governor Special Funds(No.1065-09)and Guizhou High-level Personnel Scientific Funds(No.TZJF-2010-054)
Synaptic vesicle protein 2A(SV2A) involvement has been reported in the animal models of epilepsy and in human intractable epilepsy. The difference between pharmacosensitive epilepsy and pharmacoresistant epilepsy re...
关键词:epilepsy epileptic hippocampus intractable seizure understood AEDs poorly staining assigned 
Psychic Neuronal Hypersynchronies: A New Psychiatric Paradigm?被引量:1
《Health》2014年第16期2089-2099,共11页Javier Alvarez-Rodriguez 
This paper deals with certain psychic automatisms that appear suddenly in the consciousness of the subject in a passive or automatic way and that usually are diagnosed as psychiatric symptoms or manifestations of an e...
关键词:Glutamate Hypothesis of Schizophrenia KINDLING Learning Long Term POTENTIATION Memory MYSTICISM Neuropsychopharmacological Drugs Partial Seizures REFLEX EPILEPSIES 
Pregnancy: Protection of the Hyperactive Brain, or a Risk Factor?
《Journal of Behavioral and Brain Science》2014年第7期334-341,共8页Zakaria I. Nanobashvili Irine G. Bilanishvili Arkadi G. Surmava Nata G. Bukia Marine P. Butskrikidze Lamara I. Machavariani Nino T. Samsieshvili Maia G. Barbaqadze Irma G. Khachidze Nadejda A. Khizanishvili 
The main objective of the study was to determine the effect of gestation and postgestation periods on development and course of seizure activity. The data obtained in the study showed that i) there is a reduction of b...
关键词:GESTATION KINDLING Audiogenic Seizures Rats 
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