云南高校图书馆联盟文献共享服务平台- PERAMPANEL

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Unraveling the neuroprotective effect of perampanel and lacosamide combination in the corneal kindling model for epilepsy in mice: 《Animal Models and Experimental Medicine》2025年第2期222-238,共17页Saba Tehreem Azka Sabir Maryam Farooq Waseem Ashraf Faleh Alqahtani Tanveer Ahmad Imran Imran; The authors extended their appreciation to Distinguished Scientist Fellowship program at King Saud University,Riyadh,Saudi Arabia,for funding this work through research supporting project number(RSP2024R131).; Background:Scientific evidence to guide clinicians on the use of different antiseizure drugs in combination therapy is either very limited or lacking.In this study,the impact of lacosamide and perampanel alone and in ...; 关键词：behavioral studies corneal kindling LACOSAMIDE learned helplessness oxidative stress PERAMPANEL

Effective treatment of NR2F1-related epilepsy with perampanel: 《Acta Epileptologica》2023年第4期238-255,共18页Xiao Li Kai Gao Yutang Li Yuehua Zhang Han Zhang Yuwu Jiang; Background NR2F1 mutations are associated with Bosch-Boonstra-Schaaf optic atrophy syndrome(BBSOAS).Although~46.7%of BBSOAS patients present with epilepsy,which is always drug-resistant and associated with higher rate...; 关键词：NR2F1 EPILEPSY Bosch-Boonstra-Schaaf optic atrophy syndrome PERAMPANEL Infantile spasm

Efficacy of perampanel as an adjunctive therapy in pediatric focal epilepsy: 《World Journal of Pediatrics》2023年第11期1111-1114,共4页Wei‑Ran Zhang Liu Liu Lu Xu Yi Hua Xiao‑Jun Su Pei‑Fang Jiang Zhe‑Feng Yuan Feng Gao; Epilepsy is the most common neurological disease,affecting approximately 50 million people worldwide[1].Many novel antiepileptic drugs(AEDs)displaying diverse mechanisms of action have been introduced[2].Although newe...; 关键词：DRUGS EPILEPSY AEDS

Young children with multidrug-resistant epilepsy and vagus nerve stimulation responding to perampanel: A case report: 《World Journal of Clinical Cases》2022年第11期3511-3517,共7页Hua Yang Dan Yu; BACKGROUND Perampanel(PER),a third-generation antiepileptic drug,is a selective and noncompetitiveα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist,and has been approved for the treatment of ad...; 关键词：PERAMPANEL Young children Drug-resistant epilepsy Vagus nerve stimulation Case report

Liquid chromatographic methods for determination of the new antiepileptic drugs stiripentol, retigabine, rufinamide and perampanel: A comprehensive and critical review被引量：2: 《Journal of Pharmaceutical Analysis》2021年第4期405-421,共17页Sara Meirinho Marcio Rodrigues Ana Fortuna Amílcar Falcao Gilberto Alves; supported by Banco Santander/Totta(Portugal)through the fellowship BID/ICI-FCS/CICS/Santander UniversidadesUBI/2017;by Foundation for Science and Technology(FCT)through the fellowship SFRH/BD/136028/2018;by FEDER funds through the POCI-COMPETE 2020-Operational Program Competitiveness and Internationalization in Axis I(Project No.POCI-01-0145FEDER-007491);National Funds by FCT(Project No.UIDB/00709/2020;and Project No.UIDP/00709/2020);the support provided by FEDER funds through the“Programa Operacional do Centro”(Project No.CENTRO-010145-FEDER-000013)。; The new antiepileptic drugs perampanel,retigabine,rufinamide and stiripentol have been recently approved for different epilepsy types.Being them an innovation in the antiepileptics armamentarium,a lot of investigation...; 关键词：BIOANALYSIS Liquid chromatography PERAMPANEL RETIGABINE RUFINAMIDE Stiripentol

Therapeutic potential of AMPA receptor antagonist perampanel against cerebral ischemia: beyond epileptic disorder被引量：2: 《Neural Regeneration Research》2019年第9期1525-1526,共2页Satoshi Suda Kazumi Kimura; Stroke is a leading cause of mortality and severe neurological disability worldwide;however,curative therapeutic options are limited.Although recanalization therapy using endovascular thrombectomy has demonstrated gre...; 关键词：Stroke is a leading NEUROLOGICAL DISABILITY improve outcomes

Perampanel: 《中国药物化学杂志》2013年第1期80-80,共1页关筱微胡春; 2012年10月22日美国FDA批准由日本卫材（Ei—sai）公司研发的perampanel（商品名：Fycompa）在美国上市，用于治疗12岁以上癫痫患者的局部发作。该药是一种口服速效的高选择性和非竞争性的α-氨基-3-羟基-5-甲基-4-异嚼唑丙酸（AMPA）...; 关键词：癫痫患者局部发作拮抗剂

Perampanel被引量：2: 《现代药物与临床》2011年第4期330-332,共3页于鹏王彦丽杨昕; α-氨基羟甲基唑丙酸(AMPA)受体广泛分布于具有兴奋性的神经突触中,在中枢神经系统中起着重要作用,神经退行性障碍、行动障碍、精神疾病、疼痛等许多疾病都涉及到AMPA受体。日本Eisai公司的在研新药Perampanel(E2007)作为首个具有高度...; 关键词：PERAMPANEL AMPA谷氨酸盐受体拮抗剂抗癫痫临床研究

抗癫痫药Perampanel的Ⅲ期临床试验结果发布: 《中国执业药师》2010年第11期54-54,共1页; 日本卫材公司于2010年8月24日公布该公司在研新药Perampanel（代码E2007）治疗癫痫的Ⅲ期临床试验结果。这项在全球25个国家的706名患者中进行的临床研究显示，患者使用Perampanel治疗后对药物的耐受性良好，而且该药在减少发病频率和...; 关键词：Ⅲ期临床试验抗癫痫药临床研究发病频率耐受性应答率治疗患者

卫材推迟perampanel的开发进程: 《国外药讯》2008年第4期15-16,共2页王蕾（摘）; 卫材公司的帕金森病治疗种类中第一个药物perampanel（E2007）（I）的申请许可证计划推迟近一年至2008年财政年度的第四季度。正在进行的三项试验都在研究这种口服AMPA拮抗剂作为左旋多巴（Ⅱ）的添加治疗用于有衰弱症状的自发性疾病。; 关键词：AMPA拮抗剂添加治疗帕金森病左旋多巴许可证自发性

PERAMPANEL