RETIGABINE

作品数：16被引量：28H指数：4
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相关领域：医药卫生更多>>
相关作者：邵凤李杰陶春蕾任建辉卞希玲更多>>
相关机构：河北医科大学广东药科大学川北医学院安徽中医药大学更多>>
相关期刊：《中国药科大学学报》《药学进展》《Acta Pharmacologica Sinica》《国外药讯》更多>>
相关基金：国家重点基础研究发展计划国家自然科学基金安徽省自然科学基金更多>>
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Functional characterization and in vitro pharmacological rescue of KCNQ2 pore mutations associated with epileptic encephalopathy
《Acta Pharmacologica Sinica》2023年第8期1589-1599,共11页Gui-mei Yang Fu-yun Tian Yan-wen Shen Chuan-yan Yang Hui Yuan Ping Li Zhao-bing Gao 
funding from the High-level New R&D Institute (2019B090904008);the High-level Innovative Research Institute (2021B0909050003)of the Department of Science and Technology of Guangdong Province;National Science and Technology Innovation 2030 Major Program (2021ZD0200900);Shanghai Municipal Science and Technology Major Project (2018SHZDZX05);Zhongshan Municipal Bureau of Science and Technology (CXTD2022013);the National Science Fund for Distinguished Young Scholars (81825021);PL received funding from the National Natural Science Foundation of China (32100621 and 82273913);Guangdong Basic and Applied Basic Research Foundation (2022A1515010851);Zhongshan Municipal Bureau of Science and Technology (220418134367984);FYT received funding from Zhongshan Municipal Bureau of Science and Technology (210724194041939).
Mutations in the KCNQ2 gene encoding KV7.2 subunit that mediates neuronal M-current cause a severe form of developmental and epileptic encephalopathy(DEE).Electrophysiological evaluation of KCNQ2 mutations has been pr...
关键词：developmental and epileptic encephalopathy(DEE) KCNQ2 pore mutations retigabine(RTG) pynegabine(HN37) XEN1101 ELECTROPHYSIOLOGY 
Liquid chromatographic methods for determination of the new antiepileptic drugs stiripentol, retigabine, rufinamide and perampanel: A comprehensive and critical review被引量：2
《Journal of Pharmaceutical Analysis》2021年第4期405-421,共17页Sara Meirinho Marcio Rodrigues Ana Fortuna Amílcar Falcao Gilberto Alves 
supported by Banco Santander/Totta(Portugal)through the fellowship BID/ICI-FCS/CICS/Santander UniversidadesUBI/2017;by Foundation for Science and Technology(FCT)through the fellowship SFRH/BD/136028/2018;by FEDER funds through the POCI-COMPETE 2020-Operational Program Competitiveness and Internationalization in Axis I(Project No.POCI-01-0145FEDER-007491);National Funds by FCT(Project No.UIDB/00709/2020;and Project No.UIDP/00709/2020);the support provided by FEDER funds through the“Programa Operacional do Centro”(Project No.CENTRO-010145-FEDER-000013)。
The new antiepileptic drugs perampanel,retigabine,rufinamide and stiripentol have been recently approved for different epilepsy types.Being them an innovation in the antiepileptics armamentarium,a lot of investigation...
关键词：BIOANALYSIS Liquid chromatography PERAMPANEL RETIGABINE RUFINAMIDE Stiripentol 
KCNQ Channels in the Mesolimbic Reward Circuit Regulate Nociception in Chronic Pain in Mice被引量：7
《Neuroscience Bulletin》2021年第5期597-610,共14页Hao-Ran Wang Su-Wan Hu Song Zhang Yu Song Xiao-Yi Wang Lei Wang Yang-Yang Li Yu-Mei Yu He Liu Di Liu Hai-Lei Ding Jun-Li Cao 
supported by grants from the National Natural Science Foundation of China (31771161, 81720108013, 81230025, 81200859 and 81801096);Key Project of Nature Science Foundation of Jiangsu Education Department (17KJA320005);Natural Science Foundation of Jiangsu Province (BK20171159);the Qing-Lan Project of Jiangsu, the Six Talent Summit Project of Jiangsu;the 333 High-level Personnel Training Project of Jiangsu;the Priority Academic Program Development of Jiangsu Higher Education Institutions, the Jiangsu Provincial Special Program of Medical Science (BL2014029);the Postgraduate Research & Practice Innovation Program of Jiangsu Province (KYCX19–2241 and KYCX20_2449), China。
Mesocorticolimbic dopaminergic(DA) neurons have been implicated in regulating nociception in chronic pain, yet the mechanisms are barely understood. Here, we found that chronic constructive injury(CCI) in mice increas...
关键词：NOCICEPTION Mesocorticolimbic system Ventral tegmental area Brain-derived neurotrophic factor KCNQ RETIGABINE Chronic neuropathic pain 
Kv7 channels a potential therapeutic target in fibromyalgia: A hypothesis
《World Journal of Pharmacology》2018年第1期1-9,共9页Kim Lawson 
Fibromyalgia is characterized by the primary symptomsof persistent diffuse pain, fatigue, sleep disturbance and cognitive dysfunction. Persistent pain conditions, such as fibromyalgia, are often refractory to current ...
关键词：FIBROMYALGIA PERSISTENT pain Potassium CHANNELS Kv7 CHANNELS FLUPIRTINE RETIGABINE 
Pharmacological modulation of the voltage-gated neuronal Kv7/KCNQ/M-channel alters the intrinsic excitability and synaptic responses of pyramidal neurons in rat prefrontal cortex slices被引量：3
《Acta Pharmacologica Sinica》2017年第9期1248-1256,共9页Hui PENG Xi-ling BIAN Fu-cui MA Ke-Wei WANG 
The prefrontal cortex （PFC） critical for higher cognition is implicated in neuropsychiatric diseases, such as Alzheimer＇s disease, depression and schizophrenia. The voltage-activated Kv7/KCNQ/M-channel or M-current...
关键词：Kv7 KCNQ M-CURRENT prefrontal cortex pyramidal neurons EXCITABILITY MEPSC RETIGABINE XE991 neuropsychiatric diseases 
Activation of neuronal Kv7/KCNQ/M-channels by the opener QO58-1ysine and its anti-nociceptive effects on inflammatory pain in rodents被引量：4
《Acta Pharmacologica Sinica》2016年第8期1054-1062,共9页Bo-chuan TENG Yan SONG Fan ZHANG Tian-yang MA Jin-Iong QI Hai-lin ZHANG Gang LI KeWei WANG 
Aim： The aim of this study was to examine the activation of neuronal Kv7/KCNQ channels by a novel modified Kv7 opener QO58-1ysine and to test the anti-nociceptive effects of QO58-1ysine on inflammatory pain in rodent...
关键词：QO58-1ysine Kv7/KCNQ M-channel pharmacokinetics XE991 RETIGABINE inflammatory pain 
Retigabine alleviates chronic restraint stress -induced memory retrieval impairment in male mice
《中国药理学通报》2015年第B11期69-69,共1页
Aim To investigate whether Kv7 channels opener retigabine could alleviate memory impairment induced by chronic restraint stress （CRS） and the underlying neuroprotective mechanisms. Methods Adult male Kunming （KM） ...
关键词：RETIGABINE chronic RESTRAINT stress (CRS) memory HIPPOCAMPUS Akt/GSK-3β 
Development and validation of a stability-indicating HPLC method for the determination of retigabine and its related substances in drug substances被引量：1
《Journal of Chinese Pharmaceutical Sciences》2015年第4期241-249,共9页吴锡凤 邵凤 陶春蕾 李杰 
Natural Science Foundation of Anhui Province(Gr ant No.KJ2014A132);"the Recruitment Program"of Anhui Province Graduate
A stability-indicating high-performance liquid chromatography（HPLC） method has been developed and validated for the separation and determination of Retigabine and its related substances. The chromatographic separati...
关键词：Retigabine HPLC Related substances Forced degradation 
Targeting voltage-gated Kv7/KCNQ/M-channel for therapeutic potential of neuropsychiatric disorders
《Journal of Chinese Pharmaceutical Sciences》2014年第1期5-15,共11页卞希玲 王克威 
National Natural Science Foundation of China(Grant No.81000552,30970919 and 81221002);the Ministry of Science and Technology of China(Grant No.2013CB531300)
M-type potassium current （IM） was initially isolated from sympathetic neurons in 1980 and named as it was inhibited by muscarine. In 1998, the molecular identity of M-current was revealed to be heterotetramers of KC...
关键词：Kv7.2 RETIGABINE XE991 EPILEPSY PAIN 
Discovery of a retigabine derivative that inhibits KCNQ2 potassium channels被引量：4
《Acta Pharmacologica Sinica》2013年第10期1359-1366,共8页Hai-ning HU Ping-zheng ZHOU Fei CHEN Min LI Fa-jun NAN Zhao-bing GAO 
The project was supported by National Science and Techno- logy Major Project on ＂Key New Drug Creation and Manuf- acturing Program＂ （2013ZX09103001-016）, National Key Basic Research Program of China （2013CB910604）, and National Natural Science Foundation of China for Excellent Key Labo- ratory （81123004）.
Aim： Retigabine, an activator of KCNQ2-5 channels, is currently used to treat partial-onset seizures. The aim of this study was to explore the possibility that structure modification of retigabine could lead to novel...
关键词：KCNQ2 channel RETIGABINE HN38 XE991 structure modification CliO cell whole-cell recording 
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