Liquid chromatographic methods for determination of the new antiepileptic drugs stiripentol, retigabine, rufinamide and perampanel: A comprehensive and critical review  

作　　者：Sara Meirinho Marcio Rodrigues Ana Fortuna Amílcar Falcao Gilberto Alves 

机构地区：[1]Faculty of Health Sciences,Health Sciences Research Center,University of Beira Interior(CICS UBI),6200-506,Covilha,Portugal [2]Research Unit for Inland Development,Polytechnic Institute of Guarda(UDI-IPG),6300-654,Guarda,Portugal [3]Coimbra Institute for Biomedical Imaging and Translational Research(CIBIT),University of Coimbra,3000-548,Coimbra,Portugal [4]Laboratory of Pharmacology,Faculty of Pharmacy,University of Coimbra,3000-548,Coimbra,Portugal

出　　处：《Journal of Pharmaceutical Analysis》2021年第4期405-421,共17页药物分析学报（英文版）

基　　金：supported by Banco Santander/Totta(Portugal)through the fellowship BID/ICI-FCS/CICS/Santander UniversidadesUBI/2017;by Foundation for Science and Technology(FCT)through the fellowship SFRH/BD/136028/2018;by FEDER funds through the POCI-COMPETE 2020-Operational Program Competitiveness and Internationalization in Axis I(Project No.POCI-01-0145FEDER-007491);National Funds by FCT(Project No.UIDB/00709/2020;and Project No.UIDP/00709/2020);the support provided by FEDER funds through the“Programa Operacional do Centro”(Project No.CENTRO-010145-FEDER-000013)。

摘　　要：The new antiepileptic drugs perampanel,retigabine,rufinamide and stiripentol have been recently approved for different epilepsy types.Being them an innovation in the antiepileptics armamentarium,a lot of investigations regarding their pharmacological properties are yet to be performed.Besides,considering their broad anticonvulsant activities,an extension of their therapeutic indications may be worthy of investigation,especially regarding other seizure types as well as other central nervous system disorders.Although different liquid chromatographic(LC)methods coupled with ultraviolet,fluorescence,mass or tandem-mass spectrometry detection have already been developed for the determination of perampanel,retigabine,rufinamide and stiripentol,new and more cost-effective methods are yet required.Therefore,this review summarizes the main analytical aspects regarding the liquid chromatographic methods developed for the analysis of perampanel,retigabine(and its main active metabolite),rufinamide and stiripentol in biological samples and pharmaceutical dosage forms.Furthermore,the physicochemical and stability properties of the target compounds will also be addressed.Thus,this review gathers,for the first time,important background information on LC methods that have been developed and applied for the determination of perampanel,retigabine,rufinamide and stiripentol,which should be considered as a starting point if new(bio)analytical techniques are aimed to be implemented for these drugs.

关 键 词：BIOANALYSIS Liquid chromatography PERAMPANEL RETIGABINE RUFINAMIDE Stiripentol 

分 类 号：R971.6[医药卫生—药品]