FLUPIRTINE

作品数：5被引量：0H指数：0
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相关领域：医药卫生化学工程更多>>
相关作者：孟庆伟黄鹏程李彩郭莲军徐旭林更多>>
相关机构：大连理工大学华中科技大学更多>>
相关期刊：《Cancer Biology & Medicine》《Journal of Chinese Pharmaceutical Sciences》《中国药理学与毒理学杂志》《World Journal of Pharmacology》更多>>
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N-acetylcysteine and reduced glutathione reverse flupirtine-induced liver injury and pro⁃duce other beneficial effects in combination with flupirtine
《中国药理学与毒理学杂志》2023年第S01期28-29,共2页CHEN Yanming CHEN Jinsong 
Priority Academic Program Development of Jiangsu Higher Education Institutions(2022JSPAPD006)。
OBJECTIVE To assess whether N-acetylcysteine(NAC)and reduced glutathione(GSH)are effective in reversing flupirtine-induced hepatotoxicity and whether they have other beneficial effects when combined with flupirtine.ME...
关键词：N-ACETYLCYSTEINE reduced glutathione FLUPIRTINE HEPATOTOXICITY 
Quantification of flupirtine and its active metabolite D-13223 in human plasma by LC-MS/MS: application to a clinical trial of flupirtine maleate capsules in healthy male Chinese volunteers
《Journal of Chinese Pharmaceutical Sciences》2021年第10期822-830,共9页Yanfang Liu Jiashan Zhang Yunbiao Tang Hua Huo 
In the present study, we developed a simple, sensitive, precise, and accurate liquid chromatography-tandem mass spectrometric(LC-MS/MS) method and validated such approach for simultaneous determination of flupirtine a...
关键词：FLUPIRTINE D-13223 LC-MS/MS Clinical trial 
Pharmacology and clinical applications of flupirtine:Current and future options
《World Journal of Pharmacology》2019年第1期1-13,共13页Kim Lawson 
Flupirtine is the first representative in a class of triaminopyridines that exhibits pharmacological properties leading to the suppression of over-excitability of neuronal and non-neuronal cells. Consequently,this dru...
关键词：FLUPIRTINE Kv7 channels GABAA receptors ANALGESIA Seizures NEUROPROTECTION Myotonia Memory TINNITUS 
Kv7 channels a potential therapeutic target in fibromyalgia: A hypothesis
《World Journal of Pharmacology》2018年第1期1-9,共9页Kim Lawson 
Fibromyalgia is characterized by the primary symptomsof persistent diffuse pain, fatigue, sleep disturbance and cognitive dysfunction. Persistent pain conditions, such as fibromyalgia, are often refractory to current ...
关键词：FIBROMYALGIA PERSISTENT pain Potassium CHANNELS Kv7 CHANNELS FLUPIRTINE RETIGABINE 
Effect of flupirtine on the growth and viability of U373 malignant glioma cells
《Cancer Biology & Medicine》2013年第3期142-147,共6页Elango Panchanathan Gnanasambandan Ramanathan Bhaskar Venkata Kameswara Subrahmanya Lakkakula 
supported by an intramural grant from Sri Ramachandra University,Chennai
Objective： Flupirtine is a non-opioid analgesic without antipyretic or antiphlogistic properties but with favorable tolerability in humans. ＂Ibis analgesic also exhibits neuroprotective activities. Furthermore, flup...
关键词：FLUPIRTINE N-METHYLASPARTATE ANALGESICS GLIOMA 
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