Pregnancy: Protection of the Hyperactive Brain, or a Risk Factor?  

作　　者：Zakaria I. Nanobashvili Irine G. Bilanishvili Arkadi G. Surmava Nata G. Bukia Marine P. Butskrikidze Lamara I. Machavariani Nino T. Samsieshvili Maia G. Barbaqadze Irma G. Khachidze Nadejda A. Khizanishvili 

机构地区：[1]Department of Neurophysiology, Ivane Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia

出　　处：《Journal of Behavioral and Brain Science》2014年第7期334-341,共8页行为与脑科学期刊（英文）

摘　　要：The main objective of the study was to determine the effect of gestation and postgestation periods on development and course of seizure activity. The data obtained in the study showed that i) there is a reduction of both EEG and behavioral seizures during gestation in the presence of hippocampal epileptogenic locus (kindling model);ii) suppression of audiogenic seizures occurs in gestation, and development of audiogenic kindling and decrease of seizure reactions occur in the pseudogestation state. It is assumed that in gestation period the intensification of the possible endogenous inhibitory mechanisms follows the course of seizure activity.The main objective of the study was to determine the effect of gestation and postgestation periods on development and course of seizure activity. The data obtained in the study showed that i) there is a reduction of both EEG and behavioral seizures during gestation in the presence of hippocampal epileptogenic locus (kindling model);ii) suppression of audiogenic seizures occurs in gestation, and development of audiogenic kindling and decrease of seizure reactions occur in the pseudogestation state. It is assumed that in gestation period the intensification of the possible endogenous inhibitory mechanisms follows the course of seizure activity.

关 键 词：GESTATION KINDLING Audiogenic Seizures Rats 

分 类 号：R73[医药卫生—肿瘤]