PILOCARPINE

作品数：38被引量：59H指数：4
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相关领域：医药卫生更多>>
相关作者：游自立殷亚萍刘勇唐锋儒刘建新更多>>
相关机构：华中科技大学西安交通大学电子科技大学山西医科大学更多>>
相关期刊：《国际眼科杂志》《Chinese Journal of Integrative Medicine》《Pharmacology & Pharmacy》《International Journal of Ophthalmology(English edition)》更多>>
相关基金：国家自然科学基金国家教育部博士点基金湖北省自然科学基金重庆市教委科研基金更多>>
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Nedl1 knockout ameliorates cognitive impairment and improves epilepsy threshold in pilocarpine-induced epileptic mice
《Acta Epileptologica》2025年第1期68-77,共10页Qian Lu Mengjia Liu Shufang Guo Yangyang Wang Liping Zou 
supported by the National Natural Science Foundation of China(81471329).
Background Epilepsy is a common neurological disorder.The homologous to E6-AP carboxy terminus(HECT)E3 ligase is associated with epilepsy.NEDD4-like ubiquitin protein ligase-1(NEDL1)is a HECT E3 ligase that is highly ...
关键词：EPILEPSY Cognitive impairment KNOCKOUT Nedl1 
Effect of Cyclooxygenase Inhibition on P-Glycoprotein Expression and Phenytoin Level in Brain Tissue of Pilocarpine Induced Epilepsy in Rats
《Journal of Biosciences and Medicines》2023年第8期169-191,共23页Reham M. Elsayed Amira S. Mohamed Mona K. Tawfik Magda M. Hagras 
Background: Increased brain P-glycoprotein (P-gp) expression may play important role in resistance to antiseizure drugs. The present work aimed to overcome the drug resistance that develop due to overexpression of P-g...
关键词：P-GLYCOPROTEIN Glutamate PHENYTOIN INDOMETHACIN CELECOXIB EPILEPSY 
Sphingosine 1-phosphate receptor 1 regulates bloodbrain barrier permeability in epileptic mice被引量：3
《Neural Regeneration Research》2023年第8期1763-1769,共7页Li-Xiang Yang Yuan-Yuan Yao Jiu-Rong Yang Hui-Lin Cheng Xin-Jian Zhu Zhi-Jun Zhang 
supported by the National Natural Science Foundation of China,Nos.82071393(to HLC),81830040(to ZJZ),82130042(to ZJZ);Science and Technology Program of Guangdong Province,No.2018B030334001(to ZJZ);the Program of Excellent Talents in Medical Science of Jiangsu Province,No.JCRCA2016006(to ZJZ)。
Destruction of the blood-brain barrier is a critical component of epilepsy pathology.Several studies have demonstrated that sphingosine 1-phosphate receptor 1 contributes to the modulation of vascular integrity.Howeve...
关键词：adeno-associated virus ASTROCYTES blood-brain barrier EPILEPSY epilepsy-associated depression-like behavior NEUROINFLAMMATION PENTYLENETETRAZOL PILOCARPINE tight junction 
Eucalyptol prevents pilocarpine-induced seizure and neuronal damage in mice,through the cholinergic,monoaminergic and antioxidant pathways
《Food Bioscience》2023年第3期3059-3066,共8页Daniel Souza Bezerra Gyllyandeson de Araujo Delmondes Maria Janice Pereira Lopes Isaac Moura Araujo Giovana Mendes de Lacerda Leite Maysa de Oliveira Barbosa Roseli Barbosa Adriano Francisco Alves Cassio Rocha Medeiros Sloana Giesta Lemos Florencio Irwin Rose Alencar de Menezes Henrique Douglas Melo Coutinho Cicero Francisco Bezerra Felipe Marta Regina Kerntopf 
supported by the Cearense Foundation for Support to Scientific(Fundaçāo Cearense de Apoio ao Desenvolvimento Científico e Tecnológico)[grant number:BMD-0008-01254.01.16/18,2018];the Regional University of Cariri.
Current antiepileptic drugs can inhibit seizure occurrence but are not effective in preventing its onset.Moreover,they produce several side effects,which may impact the efficacy of the treatment.In addition,it has bee...
关键词：SEIZURE PILOCARPINE EUCALYPTOL MONOAMINES ANTIOXIDANT Neuroprotection 
Anticonvulsant Effects of Chrysanthellum americanum L. (Vatke) Aqueous Extract in Mice Pilocarpine Model of Epilepsy and Associated Memory Impairment: Role of Antioxidant Defense System and Cholinergic Transmission
《Journal of Biosciences and Medicines》2023年第6期81-102,共22页Yvette Nguezeye Fanta Sabine Adeline Yadang Simon Pale Vanessa Tita Jugha Hart Mann Alain Youbi Mambou Raymond Bess Bila Tambong Ako Ojongnkpot Germain Sotoing Taiwe Gabriel Agbor Agbor Elisabeth Ngo Bum 
Chrysanthellum americanum (L.) Vatke is a medicinal plant used by the traditional healers to treat epilepsy and associated memory impairment. This work aims at evaluating the anticonvulsant effects of Chrysanthellum a...
关键词：Chrysanthellum americanum EPILEPSY Memory Impairment Oxidative Stress Cholinergic Transmission 
A Single Hypoxic Event Ameliorates Pilocarpine Induced Hyperkinetic Movements in Planaria
《Natural Science》2022年第4期149-156,共8页Teagan Neufeld Trevor N. Carniello Blake T. Dotta 
Intermittent hypoxia or hypoxia therapy is exposing an individual to oxygenation conditions that are below atmospheric levels in a planned or acute timeframe. Hypoxia therapy is a potentially novel therapeutic strateg...
关键词：HYPOXIA PILOCARPINE PLANARIA Hyperkinetic Movements Seizure Model 
The effects of calcineurin inhibitor FK506 on actin cytoskeleton,neuronal survival and glial reactions after pilocarpine-induced status epilepticus in mice
《解剖学杂志》2021年第S01期108-109,共2页Wang Xinyi Huang Xinlei Zhang Song Xiong Tianqing Wang Yingge 
After status epilepticus(SE),actin cytoskeleton(F actin)becomes progressively deconstructed in the hippocampus.A variety of experiments show that calcineurin inhibitors such as FK506 are able to inhibit the SE-induced...
关键词：FK506 epileptic CALCINEURIN 
Dynamic structural neuroplasticity during and after epileptogenesis in a pilocarpine rat model of epilepsy
《Acta Epileptologica》2021年第1期15-23,共9页Soomaayeh Heysieattalab Leila Sadeghi 
Background:The role of neuroplasticity in epilepsy has been widely studied in experimental models and human brain samples.However,the results are contradictory and it remains unclear if neuroplasticity is more related...
关键词：EPILEPTOGENESIS NEUROPLASTICITY Spine numbers Dendritic complexity NEUROGENESIS 
Linsitinib (OSI‑906) modulates brain energy metabolism and seizure activity in the lithium‑pilocarpine rat model
《Acta Epileptologica》2021年第1期114-125,共12页Guohui Jiang Shenglin Wang Mingyue Chen Xiaomi Ding Weiwei He Li Wang Shunxian Wang Juming Yu Xiaoming Wang 
supported by the National Natural Science Foundation of China(No.81971220);the Science and Postdoctoral Science Foundation of China(No.2019M653978).
Background:Epileptic seizure is a process of energy accumulation,bursting,and depletion accompanied by the production,spread,and termination of epileptic discharges.The energy required for a seizure is mainly provided...
关键词：EPILEPSY MITOCHONDRIA Energy metabolism Insulin receptor IGF-1 receptor Akt signaling 
Pinellia Total Alkaloids Modulate the GABAergic System in Hippocampal Formation on Pilocarpine-Induced Epileptic Rats被引量：12
《Chinese Journal of Integrative Medicine》2020年第2期138-145,共8页DENG Chu-xin WU Zhi-bing CHEN Yi YU Zheng-miao 
Objective:To investigate the neuromodulatory effect of pinellia total alkaloids(PTA)on the gamma-aminobutyric acidergic(GABAergic)system in epileptic rats,and preliminarily evaluate the anti-epileptic effect of PTA.Me...
关键词：Pineilia total alkaloids Pineilia ternata gamma-aminobutyric acidergic agents SEIZURE EPILEPSY 
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