The effects of calcineurin inhibitor FK506 on actin cytoskeleton,neuronal survival and glial reactions after pilocarpine-induced status epilepticus in mice  

作　　者：Wang Xinyi Huang Xinlei Zhang Song Xiong Tianqing Wang Yingge 

机构地区：[1]Department of Anatomy,Medical College,Yangzhou University,Yangzhou 225001

出　　处：《解剖学杂志》2021年第S01期108-109,共2页Chinese Journal of Anatomy

摘　　要：After status epilepticus(SE),actin cytoskeleton(F actin)becomes progressively deconstructed in the hippocampus.A variety of experiments show that calcineurin inhibitors such as FK506 are able to inhibit the SE-induced actin depolymerization.However,it is still unclear what changes happen to the F-actin in the epileptic brain after FK506 treatment.A pilocarpine model of SE in mice was used to examine the effects of FK506 on the F-actin in the hippocampal neurons.

关 键 词：FK506 epileptic CALCINEURIN 

分 类 号：R69[医药卫生—泌尿科学]