Background:L-dopa(Levodopa)is well known for managing PD(Parkinson’s disease);however,its prolonged use caused dyskinesia(LID).Due to the varied presentation of LID,effective treatment options are scarce.Flavonoids r...
supported by the National Natural Science Foundation of China(32171194,32371256 to Q.Q.,82225045,32071197 to S.W.);the Ministry of Science and Technology of China(2023YFA0915000 to Q.Q.,2020YFA0509600 to S.W.);the China Postdoctoral Science Foundation(2022M720805 to Z.Zhou),and the start-up funds from Shanghai Stomatological Hospital&School of Stomatology,Fudan University to Q.Q.
Monoamine neurotransmitters such as serotonin and dopamine are loaded by vesicular monoamine transporter 2(VMAT2)into synaptic vesicles for storage and subsequent release in neurons.Impaired VMAT2 function underlies v...
supported by the Cearense Foundation for Support to Scientific(Fundaçāo Cearense de Apoio ao Desenvolvimento Científico e Tecnológico)[grant number:BMD-0008-01254.01.16/18,2018];the Regional University of Cariri.
Current antiepileptic drugs can inhibit seizure occurrence but are not effective in preventing its onset.Moreover,they produce several side effects,which may impact the efficacy of the treatment.In addition,it has bee...
Brain aminergic tone was examined in rats with different genetically determined generalized epilepsies and in normal rats. Our previously published database was analyzed to examine if there were functional correlation...
Exercise performance depends on both physiological abilities (e.g., muscle strength) and behavioral characteristics (e.g., motivati on). We tested the hypothesis that evoluti on of in creased aerobic exercise performa...
Objective: To evaluate the protective effect of morin against pentylenetetrazol(PTZ)-induced tonic-clonic convulsions in mice. Methods: Swiss albino mice(18-22 g) was used to induce convulsions by intraperitoneal(i.p....
supported by the Crafoord Foundation;the Lundbeck Foundation;the Danish Medical Research Council
Monoamine neurotransmitters play an important role in the modulation of sensory, motor and autonomic functions in the spinal cord. Although traditionally it is believed that in mammalian spinal cord, monoamine neurotr...
supported by the Ministry of Science and Technology of China (2014CB239402, 2013CB834505, 2013CB834804);the National Natural Science Foundation of China (91427303, 21372232, 21204052);the Key Research Programme of the Chinese Academy of Sciences (KGZD-EW-T05);the Foundation of Director of TIPC
We develop here a simple wet chemistry to prepare covalent functionalized graphenes (FGs) through epoxide aminolysis espe- cially under alkaline aqueous condition. Remarkably, a series of typical monoamines, such as...
Understanding the mechanisms underlying complex behaviors re- quires a comprehensive investigation of the neurobiological factors that regulate and modulate their expression. Monoamines, such as serotonin, dopamine, a...
Accurate assessment of the probability of success in an aggressive confrontation with a conspecific is critical to the survival and fitness of the individuals. Various game theory models have examined these assessment...