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KNOCKOUT: 作品数：246被引量：830H指数：12; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：刘亚社王庆忠孙俊丽刘惺汤百争更多>>; 相关机构：中国科学院潍坊学院西安电子科技大学中国科学院大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划高等学校学科创新引智计划更多>>

Nedl1 knockout ameliorates cognitive impairment and improves epilepsy threshold in pilocarpine-induced epileptic mice: 《Acta Epileptologica》2025年第1期68-77,共10页Qian Lu Mengjia Liu Shufang Guo Yangyang Wang Liping Zou; supported by the National Natural Science Foundation of China(81471329).; Background Epilepsy is a common neurological disorder.The homologous to E6-AP carboxy terminus(HECT)E3 ligase is associated with epilepsy.NEDD4-like ubiquitin protein ligase-1(NEDL1)is a HECT E3 ligase that is highly ...; 关键词：EPILEPSY Cognitive impairment KNOCKOUT Nedl1

C1ql3 knockout affects microglia activation, neuronal integrity, and spontaneous behavior in Wistar rats: 《Animal Models and Experimental Medicine》2025年第2期332-343,共12页Li Zhang Wei Dong Jingwen Li Shan Gao Hanxuan Sheng Qi Kong Feifei Guan Lianfeng Zhang; The present work was supported by the National Natural Science Foundation(31970508);the National Key Research and Development Program of China(2022YFF0710702).; Background:C1QL3 is widely expressed in the brain and is specifically produced by a subset of excitatory neurons.However,its function is still not clear.We established C1ql3-deficient rats to investigate the role of C...; 关键词：C1QL3 KNOCKOUT MICROGLIA NEURON rat

DNA2 knockout aggravates cerebral ischemia/reperfusion injury by reducing postsynaptic Homer1a: 《Zoological Research》2025年第1期87-102,共16页Ting Ma Yu-Meng Li Peng-Yu Ren Shi-Quan Wang Xiang-Long Liu Wen-Bo Lv Wu-Gang Hou Wen-Qiang Zuo Wei-Qiang Lin Jian Sima An-Qi Geng; supported by the National Natural Science Foundation of China (32070979);Shenzhen Science and Technology Program (JCYJ20220530161604009,JCYJ20240813150734043);Key Research and Development Program of Shaanxi (2024SF,YBXM,050);Fundamental Research Funds for the Central Universities (31020190QD004,3102019YX01001);Double First-Class Project of China Pharmaceutical University (CPUQNJC22_02);Global Pharmaceutical Development Alliance Plan of China Pharmaceutical University (1302090024-05)。; DNA2,a multifunctional enzyme with structure-specific nuclease,5'-to-3'helicase,and DNA-dependent ATPase activities,plays a pivotal role in the cellular response to DNA damage.However,its involvement in cerebral ische...; 关键词：DNA2 Homer1a Cerebral I/R OGD/R Neuronal apoptosis

RFC2 may contribute to the pathogenicity of Williams syndrome revealed in a zebrafish model: 《Journal of Genetics and Genomics》2024年第12期1389-1403,共15页Ji-Won Park Tae-Ik Choi Tae-Yoon Kim Yu-Ri Lee Dilan Wellalage Don Jaya K.George-Abraham Laurie A.Robak Cristina C.Trandafir Pengfei Liu Jill A.Rosenfeld Tae Hyeong Kim Florence Petit Yoo-Mi Kim Chong Kun Cheon Yoonsung Lee Cheol-Hee Kim; supported by the National Research Foundation of Korea grant funded by the Korean government(MIST)(2020R1A5A8017671,2022R1A2C100677813,and RS-2024-00349650)。; Williams syndrome(WS)is a rare multisystemic disorder caused by recurrent microdeletions on 7q11.23,characterized by intellectual disability,distinctive craniofacial and dental features,and cardiovascular problems.Pre...; 关键词：Williams syndrome RFC2 RFC5 ZEBRAFISH KNOCKOUT CRISPR-Cas9

rAAV-CRISPR/Cas9-mediated in vivo delivery of porcine embryos to construct knockout pigs: 《Science China(Life Sciences)》2024年第12期2587-2589,共3页Mengyu Gao YuTing He XingLong Zhu WanLiu Peng Xinmei Liu Yanyan Zhou Yang Deng Qin Liu Guangneng Liao Yi Li Wei Ni Guang Yang Jiayin Yang Yang Yang Lang Bai Hong Bu Ji Bao; supported by the National Natural Science Foundation of China (82270662,82070640);the Postdoctoral Research and Development Fund of West China Hospital,Sichuan University (2023HXBH039);the 1.3.5 Project for Disciplines of Excellence,West China Hospital Sichuan University (ZYJC21014)。; Dear editor,Pigs are widely used for studying human disease mechanisms and gene therapy,particularly as the primary donors for xenotransplantation,because of their anatomical,physiological,and metabolic similarities t...; 关键词：CRISPR rAAV-CRISPR/Cas9-mediated in vivo delivery of porcine embryos to construct knockout pigs

Cardiomyocyte-specific knockout of ADAM17 alleviates doxorubicin-induced cardiomyopathy via inhibiting TNFα-TRAF3-TAK1-MAPK axis: 《Signal Transduction and Targeted Therapy》2024年第11期5217-5236,共20页Lin Xie Fei Xue Cheng Cheng Wenhai Sui Jie Zhang Linlin Meng Yue Lu Wenjing Xiong Peili Bu Feng Xu Xiao Yu Bo Xi Lin Zhong Jianmin Yang Cheng Zhang Yun Zhang; supported by grants of the National Natural Science Foundation of China(Nos.82000411,82030051,82241203,81920108003 and 81970366);State Key R&D Program of China(2021YFF0501403);Key R&D Program of Shandong Province(2021SFGC0503,2021ZLGX02,2021ZDSYS05,2020ZLYS05);Shandong Provincial Natural Science Foundation(ZR2020QH023);the Taishan Scholars Program of Shandong Province(C.Z.);China Postdoctoral Science Foundation(2023M742124);Postdoctoral Innovation Talents Support Program(BX20230210).; The pathogenesis of doxorubicin-induced cardiomyopathy remains unclear.This study was carried out to test our hypothesis that ADAM17 aggravates cardiomyocyte apoptosis induced by doxorubicin and inhibition of ADAM17 m...; 关键词：DOXORUBICIN CARDIOMYOPATHY markedly

Overexpression of proteasome 26S subunit non-ATPase 6 protein and its clinicopathological significance in intrahepatic cholangiocarcinoma被引量：1: 《World Journal of Hepatology》2024年第11期1282-1289,共8页Zhong-Qing Tang Yu-Lu Tang Kai Qin Qi Li Gang Chen Yu-Bin Huang Jian-Jun Li; BACKGROUND Currently,intrahepatic cholangiocarcinoma(ICC)poses a continuing,significant health challenge,but the relationship has yet to be established between ICC and the proteasome 26S subunit non-ATPase 6(PSMD6).AI...; 关键词：Intrahepatic cholangiocarcinoma Proteasome 26S subunit non-ATPase 6 Immunohistochemistry Clustered regularly interspaced short palindromic repeat knockout screening Clinicopathological characteristics

Knockout of TMEM206 in mice associated with a loss of corneal transparency: 《International Journal of Ophthalmology(English edition)》2024年第11期1967-1972,共6页Zi-Jian Yang Shou-Yue Huang Yu-Feng Zhou Shun-Chang Sun; Supported by National Natural Science Foundation of China(No.31571294).; AIM:To investigate the role of transmembrane protein 206(TMEM206)in corneal edema in mice by knockout the TMEM206 gene using CRISPR/Cas9 editing technology.METHODS:TMEM206-knockout mice were generated using the CRISPR...; 关键词：transmembrane protein 206 KNOCKOUT CORNEA EDEMA MOUSE

Effects of Kv1.3 knockout on pyramidal neuron excitability and synaptic plasticity in piriform cortex of mice: 《Acta Pharmacologica Sinica》2024年第10期2045-2060,共16页Yong-sheng Zhou Hao-bo Tao Si-si Lv Ke-qin Liang Wen-yi Shi Ke-yi Liu Yun-yun Li Lv-yi Chen Ling Zhou Shi-jin Yin Qian-ru Zhao; supported by National Natural Sciences Foundation of China(32000685);Knowledge Innovation Program of Wuhan-Shuguang Project(2022020801020412);Natural Sciences Foundation of Hubei Province(2020CFB348);Fundamental Research Funds for the Central Universities,South-Central Minzu University(CZQ23026)to QZ;partly by National Natural Sciences Foundation of China(81373379,81641186);National Key R and D Program of China(2019YFC1712402);Fundamental Research Funds for the Central Universities,South-Central Minzu University(CZZ19005)to SY.; Kv1.3 belongs to the voltage-gated potassium(Kv)channel family,which is widely expressed in the central nervous system and associated with a variety of neuropsychiatric disorders.Kv1.3 is highly expressed in the olfac...; 关键词：Kv1.3 piriform cortex neuronal excitability synaptic plasticity olfactory recognition

Corrigendum:Sorl1 knockout inhibits expression of brain-derived neurotrophic factor:involvement in the development of late-onset Alzheimer’s disease: 《Neural Regeneration Research》2024年第10期2211-2211,共1页; https://doi.org/10.4103/1673-5374.393108 In the article titled“Sorl1 knockout inhibits expression of brain-derived neurotrophic factor:involvement in the development of late-onset Alzheimer’s disease”,published on ...; 关键词：INVOLVEMENT ALZHEIMER

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