KNOCKOUT

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Modulation of colonic DNA methyltransferase by mild moxibustion and electroacupuncture in ulcerative colitis TET2 knockout mice
《Digital Chinese Medicine》2025年第1期100-110,共11页Gege FENG Yue ZHANG Huangan WU Lu ZHU Hongxiao XU Zhe MA Yan HUANG 
National Natural Science Foundation of China(82274641,81873372,and 82105012).
Objective To investigate the mechanism of in alleviating colonic mucosal inflammation in ten-eleven translocation(TET)protein 2 gene knockout(TET2^(-/-))mice with ulcerative colitis(UC)by regulating DNA methyltransfer...
关键词：Ulcerative colitis TET2 knockout Mild moxibustion ELECTROACUPUNCTURE DNA methyltransferase DNA hydroxymethylase 
Conditional Tnfaip6‑Knockout in Inner Ear Hair Cells Does not Alter Auditory Function
《Neuroscience Bulletin》2025年第3期421-433,共13页Yue Qiu Song Gao Xiaoqiong Ding Jie Lu Xinya Ji Wenli Hao Siqi Cheng Haolinag Du Yajun Gu Chenjie Yu Cheng Cheng Xia Gao 
supported by grants from the National Natural Science Foundation of China(82192862,82371157,82201303,and 82271173);the Natural Science Foundation of Jiangsu Province(BE2023653,BK20230025,and BK20200133);the China Postdoctoral Science Foundation(2020M681555);a Distinguished Young Scholar supported by the Medical Science and Technology Development Foundation,Nanjing Department of Health(JQX20003).
Noise-induced hearing loss is a worldwide public health issue that is characterized by temporary or permanent changes in hearing sensitivity.This condition is closely linked to inflammatory responses,and interventions...
关键词：Noise Tnfaip6 Hair cells Hearing loss 
Nedl1 knockout ameliorates cognitive impairment and improves epilepsy threshold in pilocarpine-induced epileptic mice
《Acta Epileptologica》2025年第1期68-77,共10页Qian Lu Mengjia Liu Shufang Guo Yangyang Wang Liping Zou 
supported by the National Natural Science Foundation of China(81471329).
Background Epilepsy is a common neurological disorder.The homologous to E6-AP carboxy terminus(HECT)E3 ligase is associated with epilepsy.NEDD4-like ubiquitin protein ligase-1(NEDL1)is a HECT E3 ligase that is highly ...
关键词：EPILEPSY Cognitive impairment KNOCKOUT Nedl1 
Hepatic Surf4 Deficiency Impairs Serum Amyloid A1 Secretion and Attenuates Liver Fibrosis in Mice
《Research》2025年第1期921-934,共14页Bingxiang Wang Huili Li Govind Gill Xiangyan Zhang Geru Tao Boyan Liu Lei Zhai Wei Chen Hao Wang Hong-Mei Gu Shucun Qin Da-Wei Zhang 
supported by the National Natural Science Foundation of China(NSFC 81929002);a grant from the Canadian Institutes of Health Research(PS 178091);the Academic promotion program of Shandong First Medical University(2019QL010);the Natural Science Foundation of Shandong Province(ZR2021MH015);D.W.Z.was also supported by the Natural Sciences and Engineering Research Council of Canada(RGPIN-2016-06479);S.Q.was also supported by the Taishan Scholars Foundation of Shandong Province(ts201511057).
Liver fibrosis is a severe global health problem.However,no effective antifibrotic drugs have been approved.Surf4 is primarily located in the endoplasmic reticulum(ER)and mediates the transport of secreted proteins fr...
关键词：golgi apparatusknockout proteomics collagen antifibrotic drugs serum amyloid liver fibrosis endoplasmic reticulum er 
LEAFY1 and 2 are required for floral organ development in soybean
《aBIOTECH》2025年第1期12-21,共10页Lingshuang Wang Huan Liu Lei Chen Tong Su Shichen Li Chao Fang Sijia Lu Baohui Liu Hui Yang Fanjiang Kong 
supported by the Open Competition Program of Top Ten Critical Priorities of Agricultural Science and Technology Innovation for the 14th Five-Year Plan of Guangdong Province(2022SDZG05 to F.Kong,and B.Liu);the National Natural Science Foundation of China(32090064 to F.Kong,32330074 to B.Liu,and 32301874 to L.Wang);the Natural Science Foundation of Guangdong Province(2024A1515011314 to L.Wang);the Science and Technology Innovation Special Project of Modern Seed Industry(22326316D to F.Kong).
The transition from vegetative to reproductive growth is a vital step for the reproductive success of plants.In Arabidopsis thaliana,LEAFY(LFY)plays crucial roles in inflorescence primordium and floral organ developme...
关键词：SOYBEAN LFY KNOCKOUT Floral organ development Expression analy 
C1ql3 knockout affects microglia activation, neuronal integrity, and spontaneous behavior in Wistar rats
《Animal Models and Experimental Medicine》2025年第2期332-343,共12页Li Zhang Wei Dong Jingwen Li Shan Gao Hanxuan Sheng Qi Kong Feifei Guan Lianfeng Zhang 
The present work was supported by the National Natural Science Foundation(31970508);the National Key Research and Development Program of China(2022YFF0710702).
Background:C1QL3 is widely expressed in the brain and is specifically produced by a subset of excitatory neurons.However,its function is still not clear.We established C1ql3-deficient rats to investigate the role of C...
关键词：C1QL3 KNOCKOUT MICROGLIA NEURON rat 
DNA2 knockout aggravates cerebral ischemia/reperfusion injury by reducing postsynaptic Homer1a
《Zoological Research》2025年第1期87-102,共16页Ting Ma Yu-Meng Li Peng-Yu Ren Shi-Quan Wang Xiang-Long Liu Wen-Bo Lv Wu-Gang Hou Wen-Qiang Zuo Wei-Qiang Lin Jian Sima An-Qi Geng 
supported by the National Natural Science Foundation of China (32070979);Shenzhen Science and Technology Program (JCYJ20220530161604009,JCYJ20240813150734043);Key Research and Development Program of Shaanxi (2024SF,YBXM,050);Fundamental Research Funds for the Central Universities (31020190QD004,3102019YX01001);Double First-Class Project of China Pharmaceutical University (CPUQNJC22_02);Global Pharmaceutical Development Alliance Plan of China Pharmaceutical University (1302090024-05)。
DNA2,a multifunctional enzyme with structure-specific nuclease,5'-to-3'helicase,and DNA-dependent ATPase activities,plays a pivotal role in the cellular response to DNA damage.However,its involvement in cerebral ische...
关键词：DNA2 Homer1a Cerebral I/R OGD/R Neuronal apoptosis 
RFC2 may contribute to the pathogenicity of Williams syndrome revealed in a zebrafish model
《Journal of Genetics and Genomics》2024年第12期1389-1403,共15页Ji-Won Park Tae-Ik Choi Tae-Yoon Kim Yu-Ri Lee Dilan Wellalage Don Jaya K.George-Abraham Laurie A.Robak Cristina C.Trandafir Pengfei Liu Jill A.Rosenfeld Tae Hyeong Kim Florence Petit Yoo-Mi Kim Chong Kun Cheon Yoonsung Lee Cheol-Hee Kim 
supported by the National Research Foundation of Korea grant funded by the Korean government(MIST)(2020R1A5A8017671,2022R1A2C100677813,and RS-2024-00349650)。
Williams syndrome(WS)is a rare multisystemic disorder caused by recurrent microdeletions on 7q11.23,characterized by intellectual disability,distinctive craniofacial and dental features,and cardiovascular problems.Pre...
关键词：Williams syndrome RFC2 RFC5 ZEBRAFISH KNOCKOUT CRISPR-Cas9 
rAAV-CRISPR/Cas9-mediated in vivo delivery of porcine embryos to construct knockout pigs
《Science China(Life Sciences)》2024年第12期2587-2589,共3页Mengyu Gao YuTing He XingLong Zhu WanLiu Peng Xinmei Liu Yanyan Zhou Yang Deng Qin Liu Guangneng Liao Yi Li Wei Ni Guang Yang Jiayin Yang Yang Yang Lang Bai Hong Bu Ji Bao 
supported by the National Natural Science Foundation of China (82270662,82070640);the Postdoctoral Research and Development Fund of West China Hospital,Sichuan University (2023HXBH039);the 1.3.5 Project for Disciplines of Excellence,West China Hospital Sichuan University (ZYJC21014)。
Dear editor,Pigs are widely used for studying human disease mechanisms and gene therapy,particularly as the primary donors for xenotransplantation,because of their anatomical,physiological,and metabolic similarities t...
关键词：CRISPR rAAV-CRISPR/Cas9-mediated in vivo delivery of porcine embryos to construct knockout pigs 
Cardiomyocyte-specific knockout of ADAM17 alleviates doxorubicin-induced cardiomyopathy via inhibiting TNFα-TRAF3-TAK1-MAPK axis
《Signal Transduction and Targeted Therapy》2024年第11期5217-5236,共20页Lin Xie Fei Xue Cheng Cheng Wenhai Sui Jie Zhang Linlin Meng Yue Lu Wenjing Xiong Peili Bu Feng Xu Xiao Yu Bo Xi Lin Zhong Jianmin Yang Cheng Zhang Yun Zhang 
supported by grants of the National Natural Science Foundation of China(Nos.82000411,82030051,82241203,81920108003 and 81970366);State Key R&D Program of China(2021YFF0501403);Key R&D Program of Shandong Province(2021SFGC0503,2021ZLGX02,2021ZDSYS05,2020ZLYS05);Shandong Provincial Natural Science Foundation(ZR2020QH023);the Taishan Scholars Program of Shandong Province(C.Z.);China Postdoctoral Science Foundation(2023M742124);Postdoctoral Innovation Talents Support Program(BX20230210).
The pathogenesis of doxorubicin-induced cardiomyopathy remains unclear.This study was carried out to test our hypothesis that ADAM17 aggravates cardiomyocyte apoptosis induced by doxorubicin and inhibition of ADAM17 m...
关键词：DOXORUBICIN CARDIOMYOPATHY markedly 
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