云南高校图书馆联盟文献共享服务平台- RHEB

RHEB: 作品数：40被引量：79H指数：5; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：赵子建李晓曦杜晓霞高亚男肖波更多>>; 相关机构：南方医科大学四川大学内蒙古大学华东师范大学更多>>; 相关期刊：《中国实验方剂学杂志》《科学技术与工程》《Neural Regeneration Research》《中国神经免疫学和神经病学杂志》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划教育部重点实验室开放基金湖南省中医药科研计划项目更多>>

中华绒螯蟹Rheb编码序列的克隆及表达分析: 《中国水产科学》2024年第12期1432-1440,共9页田志环焦传珍; 广东省驻镇帮扶农村科技特派员项目(KTP20210401);韶关学院重点科研项目(432-99000440);韶关学院博士引进项目(432-99000622); Rheb (Ras homologue enriched in brain,脑中富集的Ras同源物)是mTOR (mammalian or mechanistic target of rapamycin,哺乳动物雷帕霉素靶蛋白)信号通路上游重要的调控因子。为探究Rheb通过mTOR信号通路调控中华绒螯蟹(Eriocheir sine...; 关键词：中华绒螯蟹 RHEB MTOR 饥饿眼柄

ATP6AP1 was Phast-ID’ed as a long-sought GEF for Rheb: 《Cell Research》2024年第6期397-398,共2页Song Li Xinxing Ouyang Bing Su; A new study from Feng et al.developed an improved proximity labeling technology called PhastID and successfully identified the lysosomal v-ATPase subunit ATP6AP1 as an unconventional guanine nucleotide exchange factor...; 关键词：PROXIMITY activation CONSERVED

The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb被引量：2: 《Cell Research》2024年第5期355-369,共15页Ran Feng Feng Liu Ruofei Li Zhifen Zhou Zhuoheng Lin Song Lin Shengcheng Deng Yingying Li Baoting Nong Ying Xia Zhiyi Li Xiaoqin Zhong Shuhan Yang Gang Wan Wenbin Ma Su Wu Zhou Songyang; the National Natural Science Foundation of China(31930058 and 32330023 to Z.S,32070778 to S.W.,81871111 and 32071433 to F.L,32300562 to Z.Z.);the Guangdong Basic and Applied Basic Research Foundation(2020B1515020044 to F.L.,2019A1515011552 to S.W.,2022A1515111054 to Z.Z.).; Rheb is a small G protein that functions as the direct activator of the mechanistic target of rapamycin complex 1(mTORC1)to coordinate signaling cascades in response to nutrients and growth factors.Despite extensive s...; 关键词：AP1 PROXIMITY TRANSIENT

努比亚山羊Rheb基因克隆、生物信息学分析及真核表达载体构建: 《中国畜牧兽医》2024年第5期1819-1826,共8页邹菊红莫智化刘雨帆邹剑伟卢俊何海恩王璠黄艳娜蒋钦杨; 广西研究生教育创新计划项目(YCBZ2023016);国家现代农业产业体系广西牛羊产业创新团队建设项目(nycytxgxcxtd-2021-09)。; 【目的】研究旨在对努比亚山羊大脑富集Ras同源物(Ras homolog enriched in brain,Rheb)基因进行克隆和分析,并构建其真核表达载体,为进一步揭示Rheb对努比亚山羊骨骼肌调控的分子机理奠定基础。【方法】试验采用RT-PCR方法从努比亚山...; 关键词：努比亚山羊 Rheb基因生物信息学骨骼肌细胞真核表达载体

LOXL3 Inhibits Autophagy of Chondrocytes by Activating Rheb in Osteoarthritis: 《Current Medical Science》2023年第6期1195-1200,共6页Guang-ping ZHENG Chen LIU Liang ZHANG Qiang ZHONG Yun ZHANG Zhong-ming HUANG; the National Natural Science Foundation of China(No.81702187);Natural Science Foundation of Jiangxi Province(No.20202BAB206019);Science Fund for Distinguished Young Scholars of Jiangxi Province(No.20224ACB216018);Scientific Talents Grants of Jiangxi Province(No.S2018LQCQ0800);Scientific Grants of Health Commission of Jiangxi Province(No.20194048);Scientific Innovation Talents Grants of Ganzhou(No.2019-60-08);Leading Talents Grants and Ph.D.Programs Foundation of Ganzhou People’s Hospital(No.Bsqd2019003)and Academic leaders Program of Ganzhou Institutes of Health.; Objective This study aimed to investigate the potential mechanisms by which lysyl oxidase like 3(LOXL3)affects the autophagy in chondrocytes in osteoarthritis(OA),specifically through the activation of mammalian targe...; 关键词：OSTEOARTHRITIS LOXL3 RHEB mTORC1 CHONDROCYTE AUTOPHAGY

Phosphorylated S6K1 and 4E-BP1 play different roles in constitutively active Rheb-mediated retinal ganglion cell survival and axon regeneration after optic nerve injury: 《Neural Regeneration Research》2023年第11期2526-2534,共9页Jikuan Jiang Lusi Zhang Jingling Zou Jingyuan Liu Jia Yang Qian Jiang Peiyun Duan Bing Jiang; National Natural Science Foundation of China,Nos.82070967,81770930;the Natural Science Foundation of Hunan Province,No.2020jj4788 (all to BJ)。; Ras homolog enriched in brain(Rheb) is a small GTPase that activates mammalian target of rapamycin complex 1(mTORC1).Previous studies have shown that constitutively active Rheb can enhance the regeneration of sensory ...; 关键词：axon regeneration central nervous system gene therapy mRNA translation NEURODEGENERATION NEUROPROTECTION optic nerve crush Ras homolog enriched in the brain retina translation initiation

Statins markedly potentiate aminopeptidase inhibitor activity against(drug-resistant)human acute myeloid leukemia cells: 《Cancer Drug Resistance》2023年第3期430-446,共17页Gerrit Jansen Marjon Al Yehuda G.Assaraf Sarah Kammerer Johan van Meerloo Gert J.Ossenkoppele Jacqueline Cloos Godefridus J.Peters; This study was supported by Cancer Center Amsterdam grants 07/36 and 2012-1-08.; Aim: This study aimed to decipher the molecular mechanism underlying the synergistic effect of inhibitors of the mevalonate-cholesterol pathway (i.e., statins) and aminopeptidase inhibitors (APis) on APi-sensitive and...; 关键词：AMINOPEPTIDASE STATINS mevalonate pathway carboxyl esterase RHEB mTOR

柴胡含药血清通过Smad3/Rheb轴调节HFL1细胞凋亡和肌成纤维细胞转化被引量：6: 《中国实验方剂学杂志》2023年第11期89-96,共8页李妲沈枭吴趋荟郑蕾赵四林金朝晖肖雪飞范伏元; 湖南省卫生健康委员会科研计划课题项目(202203023299);湖南省教育厅科学研究项目(20B442);湖南省中医药科研计划项目(2021165);长沙市科技局重点研发计划项目(Kq1901096)。; 目的:利用转化生长因子-β_(1)(TGF-β_(1))刺激人胚肺成纤维细胞(HFL1)模拟特发性肺纤维化(IPF)的病理过程,探讨柴胡含药血清对IPF的作用和机制。方法:采用10μg·L^(-1)TGF-β_(1)刺激HFL1细胞,给予不同体积分数柴胡含药血清(5%、10%...; 关键词：特发性肺纤维化柴胡成纤维细胞 SMAD3 脑Ras同源蛋白成纤维细胞向肌成纤维细胞转化

沉默Rheb对DDP耐药非小细胞肺癌细胞活力和凋亡的影响及机制研究被引量：1: 《中国免疫学杂志》2023年第8期1683-1686,共4页段进进尚立群王莉吴桦苗毅董玉; 陕西省重点研发项目(2018SF-062)。; 目的:研究沉默Rheb对DDP耐药非小细胞肺癌(NSCLC)细胞活力和凋亡的影响,并探索其作用机制。方法:体外培养非小细胞肺腺癌细胞A549和顺铂耐药的A549细胞(A549/DDP)。转染Rheb-siRNA(si-Rheb)至A549和A549/DDP细胞。采用CCK-8法、Annexin-...; 关键词：RHEB 非小细胞肺癌耐药性 mTOR-S6信号通路凋亡

Coordinated Regulation of Myelination by Growth Factor and Amino-acid Signaling Pathways: 《Neuroscience Bulletin》2023年第3期453-465,共13页Zhiwen Yang Zongyan Yu Bo Xiao; supported by Grants from the Shenzhen Innovation Committee of Science and Technology(ZDSYS20200811144002008 to Shenzhen Key Laboratory of Gene Regulation and Systems Biology,2019193984);the National Natural Science Foundation of China(31970773 and 31530042);the Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions(2021SHIBS0002).; Myelin-forming oligodendrocytes in the central nervous system(CNS)and Schwann cells in the peripheral nervous system(PNS)are essential for structural and functional homeostasis of nervous tissue.Albeit with certain si...; 关键词：OLIGODENDROCYTE Schwann cell MYELINATION RHEB mTORC1 MIOS GATOR2 mitochondria LACTATE

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