AMINOPEPTIDASE

作品数：14被引量：16H指数：3
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相关领域：医药卫生更多>>
相关作者：刘树滔陈晋程远肖玉涛梁革梅更多>>
相关机构：福州大学中国农业科学院植物保护研究所重庆医科大学附属第二医院西北农林科技大学更多>>
相关期刊：《Medical Bulletin of Shanghai Jiaotong University》《Chemical Research in Chinese Universities》《Science Bulletin》《应用昆虫学报》更多>>
相关基金：国家自然科学基金国家科技重大专项更多>>
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Statins markedly potentiate aminopeptidase inhibitor activity against(drug-resistant)human acute myeloid leukemia cells
《Cancer Drug Resistance》2023年第3期430-446,共17页Gerrit Jansen Marjon Al Yehuda G.Assaraf Sarah Kammerer Johan van Meerloo Gert J.Ossenkoppele Jacqueline Cloos Godefridus J.Peters 
This study was supported by Cancer Center Amsterdam grants 07/36 and 2012-1-08.
Aim: This study aimed to decipher the molecular mechanism underlying the synergistic effect of inhibitors of the mevalonate-cholesterol pathway (i.e., statins) and aminopeptidase inhibitors (APis) on APi-sensitive and...
关键词：AMINOPEPTIDASE STATINS mevalonate pathway carboxyl esterase RHEB mTOR 
Aminopeptidase Play a Critical Role in the Accumulation of Free Amino Acids in Abalone(Haliotis discus hannai)During Cold Storage
《Journal of Ocean University of China》2023年第4期1049-1058,共10页REN Qiuying WANG Yujia SUN Sha ZHANG Lingjing SUN Lechang WENG Ling LIU Guangming CAO Minjie 
supported by the National Key R&D Program of China(No.2018YFD0901004);the National Natural Science Foundation of China(No.31772049).
Abalones reveal unique taste after processing,mainly because of their abundant free amino acids(FAAs)and nucleotides.FAAs are nutrition components that can contribute to the unique taste.However,which factor(s)is resp...
关键词：ABALONE AMINOPEPTIDASE PURIFICATION characterization TASTE endogenous protease texture 
Development of peptidomimetic hydroxamates as PfA-M1 and PfA-M17 dual inhibitors: Biological evaluation and structural characterization by cocrystallization
《Chinese Chemical Letters》2022年第5期2550-2554,共5页Anil Kumar Marapaka Priyanka Sankoju Guozhen Zhang Yongzheng Ding Chunhua Ma Vijaykumar Pillalamarri Renu Sudhakar Bharati Reddi Puran Singh Sijwali Yingjie Zhang Anthony Addlagatta 
supported by University Grants Commission (UGC), New Delhi, India and Bharati Reddi by Department of Science and Technology, New Delhi, India for their research fellowships;CSIR-IICT manuscript number is IICT/Pubs./2018/299;Anthony Addlagatta thanks Science and Engineering Research Board (SERB), New Delhi, India for research grants (Nos. EMR/2015/000461 and CRG/2019/006013);Natural Science Foundation of Shandong Province (No. ZR2018QH007, China);Key Research and Development Program of Shandong Province (No. 2017CXGC1401, China);Young Scholars Program of Shandong University (No. YSPSDU, 2016WLJH33, China) for research fellowships;Renu Sudhakar is the recipient of the fellowship from the Department of Biotechnology (India);Puran Singh Sijwali lab is supported with funds from the Department of Biotechnology, India (Nos. SR/SO/BB/-0124/2012 and BT/COE/34/SP15138/2015);the Council of Scientific & Industrial Research, India
Plasmodium parasites causing malaria have developed resistance to most of the antimalarials in use,in-cluding the artemisinin-based combinations,which are the last line of defense against malaria.This ne-cessitates th...
关键词：AMINOPEPTIDASE Dual inhibitor ANTIMALARIA PEPTIDOMIMETIC Plasmodium falciparum 
Human leukocyte antigen B polymorphism and association between HLA-B27 and endoplasmic reticulum aminopeptidase 1 rs30187 SNP in patients with ankylosing spondylitis in Bangladesh
《Rheumatology & Autoimmunity》2022年第1期15-21,共7页Md Kamrul H.Sajib Shamim Ahmed Syed A.Haq Minhaj R.Choudhury Mohammed Uddin Furkan Uddin Muhammad S.A.Khan Mohammad M.Zaman 
Bangabandhu Sheikh Mujib Medical University。
Objectives:To determine the association of Human leukocyte antigen B(HLA‑B)alleles with ankylosing spondylitis and the allelic association of HLAB27 with endoplasmic reticulum aminopeptidase 1(ERAP1)single-nucleotide ...
关键词：AS BANGLADESH ERAP1 rs30187 SNP HLA-B HLA-B27 
沉默APN对胶质瘤细胞U251增殖、侵袭和凋亡的影响被引量：1
《第三军医大学学报》2020年第9期908-914,共7页董云朋 程远 陈晋 
国家自然科学基金面上项目(81401505)。
目的探究aminopeptidase N(APN)对胶质瘤细胞U251增殖能力、迁移侵袭能力和凋亡等生物学行为的影响及可能的作用机制。方法通过RNA干扰技术沉默胶质瘤细胞U251中APN的表达后,运用RT-qPCR的方法检测APN mRNA表达,采用Western blot检测AP...
关键词：胶质瘤 AMINOPEPTIDASE N RNA干扰 STAT3 细胞凋亡 侵袭 
Single-Chain Expression and Crystallization of an Antigenic C-Terminus in Complex with the Regulatory Domain of ER Aminopeptidase 1
《Crystal Structure Theory and Applications》2015年第4期47-52,共6页Lufei Sui Amit Gandhi Hwai-Chen Guo 
Human endoplasmic reticulum aminopeptidase 1 (ERAP1) is one of two ER luminal aminopeptidases that participate in the final processing of peptide precursors and generates the N-termini of the MHC class I-restricted ep...
关键词：Endoplasmic Reticulum AMINOPEPTIDASE 1 (ERAP1) ERAP1 REGULATORY Domain ANTIGEN Presentation X-Ray CRYSTALLOGRAPHY 
棉铃虫中肠氨肽酶APN4与Cry1Ac、Cry2Aa结合能力的比较被引量：1
《应用昆虫学报》2015年第5期1229-1235,共7页袁向东 葛朝虹 肖玉涛 梁革梅 
国家转基因生物新品种培育重大专项课题(2014ZX08011-007)
【目的】Bt杀虫蛋白(Bacillus thuringiensis)具有高度的靶标特异性,已经被广泛用于农业害虫防治。Bt杀虫蛋白要发挥杀虫活性,必须首先与其受体蛋白结合,氨肽酶N(Aminopeptidase N)是一类重要的Bt受体蛋白。因此,分析该受体与Bt杀虫蛋...
关键词：棉铃虫 Bacillus THURINGIENSIS 氨肽酶N(aminopeptidase N) 结合动力学 
Clone, Purification and Characterization of Thermostable Aminopeptidase ST1737 from Sulfolobus tokodaii被引量：1
《Chemical Research in Chinese Universities》2015年第1期98-102,共5页YU Xiaoxiao HAO Weiwei XIE Guiqiu WANG Yingwu GAO Renjun 
Supported by the National Natural Science Foundation of China（No.20772046）.
The aminopeptidase gene from thermophilic archaea Sulfolobustokodaii was cloned and expressed in Escherichia coli BL21 codon-plus（DE3）. To overexpress the aminopeptidase, the vector pET32a was constructed, in which ...
关键词：AMINOPEPTIDASE Sulfolobustokodaii Thermostability 
Leukotriene-A4-Hydrolase and Basic Aminopeptidase Activities Are Related with Collagen-Induced Arthritis in a Compartment-Dependent Manner
《Open Journal of Rheumatology and Autoimmune Diseases》2013年第4期255-262,共8页Mariana Trivilin Mendes Paulo Flavio Silveira 
This study was financially supported by a Research Grant 09/17613-0 from FAPESP(Fundacao de Amparoà Pes-quisa do Estado de Sao Paulo,Brazil);P.F.S was recipient of a Productivity Grant 302533/2011-7 from CNPq(Conselho Nacional de Desenvolvimento Cientifico e Tecnologico,Brazil);M.T.M.was recipient of a CAPES(Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior,Brasil)fellowship.
Objective: Previous study demonstrated the involvement of basic aminopeptidase (APB) activity in the development of collagen-induced arthritis (CIA). Two zinc dependent metalloenzymes (EC 3.4.11.6 and EC 3.3.2.6) are ...
关键词：AMINOPEPTIDASE Ether Hydrolase Bifunctional Enzyme EICOSANOIDS 
Case-control analysis of the <i>ERAP1</i>polymorphism rs30187 in Italian type 1 diabetes mellitus patients
《Health》2013年第12期2150-2155,共6页Elena Gianchecchi Antonino Crinò Alessia Palma Rosa Luciano Valentina Perri Doriana Fruci Marco Cappa Alessandra Fierabracci 
Autoimmune diseases are a heterogeneous group of disorders affecting different organs and tissues whose incidence are increasing worldwide. New tools, such as genome-wide association studies, have provided evidence fo...
关键词：AUTOIMMUNITY Case Control Study Endoplasmic Reticulum AMINOPEPTIDASE 1 INSULIN-DEPENDENT Diabetes Mellitus Single Nucleotide POLYMORPHISM 
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