PEPTIDOMIMETIC

作品数：10被引量：10H指数：1
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相关领域：医药卫生更多>>
相关作者：邹晓民徐萍王超杨晓鸣牛彦更多>>
相关机构：北京大学温州医科大学中国医学科学院北京协和医学院更多>>
相关期刊：《Journal of Chinese Pharmaceutical Sciences》《Chemical Research in Chinese Universities》《Bone Research》《Chinese Chemical Letters》更多>>
相关基金：国家自然科学基金北京市自然科学基金更多>>
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Computer-aided molecular design and optimization of potent inhibitors disrupting APC-Asef interaction被引量：1
《Acta Pharmaceutica Sinica B》2024年第6期2631-2645,共15页Xuefei Wang Zeqian Du Yuegui Guo Jie Zhong Kun Song Junyuan Wang Jianqiang Yu Xiuyan Yang Chen-Ying Liu Ting Shi Jian Zhang 
funded by the National Key R&D Program of China(2023YFF1205103 to Jian Zhang);the Key Research and Construction Programs of Ningxia Hui Autonomous Region(2022BEG01002 to Jian Zhang,China);the Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study(SN-ZJU-SIAS-007 to Jian Zhang,China);the National Natural Science Foundation of China(22237005 and 81925034 to Jian Zhang);the open fund of state key laboratory of Pharmaceutical Biotechnology,Nanjing University(KF-202201 to Jian Zhang,China);the open fund of Basic Science Research Center Base(Pharmaceutical Science Y202203 to Xiuyan Yang,China).
Colorectal cancer(CRC)is the second leading cause of cancer mortality worldwide.At initial diagnosis,approximately 20%of patients are diagnosed with metastatic CRC(mCRC).Although the APC-Asef interaction is a well-est...
关键词：APC-Asef PEPTIDOMIMETIC Computer-aided molecular design ONIOM model π-πstacking Metastatic colorectal cancer 
Peptidomimetic-liganded gold nanoclusters for controlled iron delivery and synergistic suppression of tumor growth
《Nano Research》2023年第10期12066-12075,共10页Xiqi Ma Duo Cai Zhixiong Zhang Qi Dai Xinyu Li Biao Yu Baosheng Ge Shihai Liu Xiaojuan Wang Fang Huang 
the National Natural Science Foundation of China(Nos.22177133,42061134020,and 32070380);the Natural Science Foundation of Shandong Province(Nos.ZR2019ZD17 and ZR2021MH022);the Qingdao Municipal People’s Livelihood Science and Technology Project(No.17-3-3-76-nsh);the Graduate Innovative Engineering Funding project of UPC(No.YCX2020041).
A novel peptidomimetic-liganded gold nanocluster(CDp-AuNC)is proposed for the synergistic suppression of tumor growth.Taking advantages of the multi-capabilities offered by the surface ligands,including iron chelation...
关键词：SELF-ASSEMBLY drug delivery ferroptosis PEPTIDOMIMETICS gold nanocluster 
Multivalent Display of Lipophilic DNA Binders for Dual-Selective Anti-Mycobacterium Peptidomimetics with Binary Mechanism of Action
《CCS Chemistry》2022年第11期3573-3586,共14页Jianxue Wang Junfeng Song Xianhui Chen Rey-Ting Guo Yingjie Wang Guopu Huang Nan Zheng Peilei Hu Xinxin Feng Yugang Bai 
This research was made possible as a result of the start-up funding from Hunan University,as a part of China’s Fundamental Research Funds for the Central Universities,the funding from the National Natural Science Foundation of China(grant nos.21877033,92163127,Y.B.,21807031,22177031,X.F.);the funding from the Natural Science Foundation of Hunan Province(grant no.2021JJ30088,Y.B.,2020JJ4177,X.F.);the Open Funding Project of the State Key Laboratory of Biocatalysis and Enzyme Engineering(Hubei University,SKLBEE2019003,X.F.).
We made oligoamidine-based peptidomimetics highly specific for mycobacteria eradication by introducing and arraying lipophilic DNA binding motifs on macromolecular backbones.The short poly(amidino-phenylindole)(PAPI)s...
关键词：PEPTIDOMIMETIC MYCOBACTERIA antimicrobial membrane disruption DNA binding 
Development of peptidomimetic hydroxamates as PfA-M1 and PfA-M17 dual inhibitors: Biological evaluation and structural characterization by cocrystallization
《Chinese Chemical Letters》2022年第5期2550-2554,共5页Anil Kumar Marapaka Priyanka Sankoju Guozhen Zhang Yongzheng Ding Chunhua Ma Vijaykumar Pillalamarri Renu Sudhakar Bharati Reddi Puran Singh Sijwali Yingjie Zhang Anthony Addlagatta 
supported by University Grants Commission (UGC), New Delhi, India and Bharati Reddi by Department of Science and Technology, New Delhi, India for their research fellowships;CSIR-IICT manuscript number is IICT/Pubs./2018/299;Anthony Addlagatta thanks Science and Engineering Research Board (SERB), New Delhi, India for research grants (Nos. EMR/2015/000461 and CRG/2019/006013);Natural Science Foundation of Shandong Province (No. ZR2018QH007, China);Key Research and Development Program of Shandong Province (No. 2017CXGC1401, China);Young Scholars Program of Shandong University (No. YSPSDU, 2016WLJH33, China) for research fellowships;Renu Sudhakar is the recipient of the fellowship from the Department of Biotechnology (India);Puran Singh Sijwali lab is supported with funds from the Department of Biotechnology, India (Nos. SR/SO/BB/-0124/2012 and BT/COE/34/SP15138/2015);the Council of Scientific & Industrial Research, India
Plasmodium parasites causing malaria have developed resistance to most of the antimalarials in use,in-cluding the artemisinin-based combinations,which are the last line of defense against malaria.This ne-cessitates th...
关键词：AMINOPEPTIDASE Dual inhibitor ANTIMALARIA PEPTIDOMIMETIC Plasmodium falciparum 
Peptidomimetic-based antibody surrogate for HER2被引量：1
《Acta Pharmaceutica Sinica B》2021年第9期2645-2654,共10页Mengmeng Zheng Chunpu Li Mi Zhou Ru Jia Fengyu She Lulu Wei Feng Cheng Qi Li Jianfeng Cai Yan Wang 
supported by USF start-up fund(Jianfeng Cai);supported by the National Natural Science Foundation of China(Qi Li,81520108031,81573764,81774095);a Municipal Human Resources Development Program for Outstanding Leaders in Medical Disciplines in Shanghai(Qi Li,2017BR031,China);Three-years Plan for the Development of T.C.M(ZY(2018e2020)-CCCX-2003-03,China)
Inhibition of human epidermal growth factor receptor 2 mediated cell signaling pathway is an important therapeutic strategy for HER2-positive cancers.Although monoclonal antibodies are currently used as marketed drugs...
关键词：HER2 ANTI-CANCER PEPTIDOMIMETICS γ-AApeptides Antibody-surrogate 
Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era被引量：9
《Acta Pharmaceutica Sinica B》2021年第9期2609-2644,共36页Liming Lin Jiaying Chi Yilang Yan Rui Luo Xiaoqian Feng Yuwei Zheng Dongyi Xian Xin Li Guilan Quan Daojun Liu Chuanbin Wu Chao Lu Xin Pan 
financially supported by the National Natural Science Foundation of China(Nos.81803467 and 81773660);the Research and Development Plan for Key Areas in Guangdong Province(Nos.2019B020204002 and 2018B030332001,China)
Membrane-disruptive peptides/peptidomimetics(MDPs)are antimicrobials or anticarcinogens that present a general killing mechanism through the physical disruption of cell membranes,in contrast to conventional chemothera...
关键词：Membrane-disruptive peptides/peptidomimetics DRUG-RESISTANCE Drug delivery systems Combination therapy 
Peptidomimetic inhibitor of L-plastin reduces osteoclastic bone resorption in aging female mice
《Bone Research》2021年第2期213-222,共10页Hanan Aljohani Joseph P.Stains Sunipa Majumdar Deepa Srinivasan Linda Senbanjo Meenakshi A.Chellaiah 
supported by the National Institutes of Health (NIH) grants under Award Number R01 AR066044 to MAC;R01 AR063631 and AR071614 to J.P.S.
L-plastin(LPL)was identified as a potential regulator of the actin-bundling process involved in forming nascent sealing zones(NSZs),which are precursor zones for mature sealing zones.TAT-fused cell-penetrating small m...
关键词：function. SEALING IMPAIRED 
Design,synthesis and biological evaluation of pyrrolidinone analogs as potential 20S proteasome inhibitors
《Journal of Chinese Pharmaceutical Sciences》2011年第6期564-571,共8页李勇剑 许凤荣 牛彦 邹晓民 袁悦 高海飞 王超 杨冠宇 孙琦 徐萍 
Beijing Natural Science Foundation(Grant No. 7112088)
A novel series of pyrrolidinone analogs that are designed as Michael addition acceptors to react irreversibly with the proteasome active site Thr1O~γhave been synthesized.Although biological evaluation results show t...
关键词：PYRROLIDINONE 20S proteasome Peptidomimetic backbone 
Synthesis and activity of hydroxyethylene peptidomimetic inhibitors of humanβ-secretase
《Journal of Chinese Pharmaceutical Sciences》2008年第3期215-220,共6页马超 王月华 杨晓鸣 邹晓民 吕杨 杜冠华 徐萍 
National Natural Science Foundation of China(Grant No.30772650 and 20772008).
A series of β-secretase peptidomimetic inhibitors with Leu＊Ala hydroxyethylene dipeptide isostere were synthesized and their β-secretase inhibitory activities were measured. The most potent compound N9 showed an in...
关键词：β-Secretase inhibitors Hydroxyethylene isostere SYNTHESIS Bioactivity 
Design and Synthesis of a Novel Peptidomimetic Inhibitor of Caspase-3被引量：1
《Chemical Research in Chinese Universities》2006年第2期225-228,共4页ZHANG Jin-liang LIU Lin-hua GUO Yang-hong YANG Jin-gang LI Wei ZHONG Da-fang WANG Ji-dong 
SupportedbytheNationalNaturalScienceFoundationofChina(No.30371675)andtheFoundationofScience&TechnologyDepartmentofJilinProvince(No.20040543).
Caspases, a family of cysteine proteases, comprise of highly homologous enzymes that play an important role in apoptotic cell death. Caspase-3 shows key functions in apoptosis, mediating apoptotic cascade from the int...
关键词：CASPASE-3 INHIBITOR Retro-inverso Peptidomimetie SYNTHESIS 
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