云南高校图书馆联盟文献共享服务平台- PEPTIDOMIMETICS

PEPTIDOMIMETICS: 作品数：19被引量：23H指数：3; 导出分析报告; 相关领域：理学医药卫生更多>>; 相关作者：杨晓鸣邹晓民徐萍傅翌秋牟科更多>>; 相关机构：北京大学更多>>; 相关期刊：《Chinese Journal of Chemistry》《中国生物学文摘》《Zoological Research》《Science China(Life Sciences)》更多>>; 相关基金：国家自然科学基金国家教育部博士点基金国家高技术研究发展计划更多>>

Transformation of peptides to small molecules in medicinal chemistry:Challenges and opportunities: 《Acta Pharmaceutica Sinica B》2024年第10期4243-4265,共23页Zeyu Han Zekai Shen Jiayue Pei Qidong You Qiuyue Zhang Lei Wang; supported by projects 82173741 and 82304309 of the National Natural Science Foundation of China;BK20230103 and BK20231014 of the Natural Science Foundation of Jiangsu Province;Young Elite Scientists Sponsorship Program by CAST(2021QNRC001,China);China Postdoctoral Science Foundation(2022M723512);Fundamental Research Funds for the Central Universities(2632023GR13,China);Jiangsu Funding Program for Excellent Postdoctoral Talent(2023ZB429,China).; Peptides are native binders involved in numerous physiological life procedures,such as cellular signaling,and serve as ready-made regulators of biochemical processes.Meanwhile,small molecules compose many drugs owing ...; 关键词：Small molecule PEPTIDE PEPTIDOMIMETICS Machine learning TRANSFORMATION MINIMIZATION Artificial intelligence

Pd(I)-catalyzed ring-opening arylation of cyclopropyl-α-aminoamides:Access toα-ketoamide peptidomimetics: 《Chinese Chemical Letters》2024年第6期320-326,共7页Yue Sun Liming Yang Yaohang Cheng Guanghui An Guangming Li; support from the University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province(No.UNPYSCT-2017124)。; We report the unprecedent Pd(I)catalyzed ring-opening arylation of cyclopropyl-α-aminoamides.This protocol allows facile access to biologically important α-ketoamide-containing oligopeptides and even more challengin...; 关键词：Pd(I)catalysis Ring-opening arylation Domino reactions Oligopeptides Late-stage functionalization

Design methods for antimicrobial peptides with improved performance被引量：1: 《Zoological Research》2023年第6期1095-1114,共20页James Mwangi Peter Muiruri Kamau Rebecca Caroline Thuku Ren Lai; This work was supported by the National Natural Science Foundation of China(31930015,32200397);Ministry of Science and Technology of China(2018YFA0801403);Chinese Academy of Sciences(XDB31000000,KFJ-BRP-008-003);Yunnan Province Grant(202003AD150008,202002AA100007);Kunming Science and Technology Bureau(2023SCP001);New Cornerstone Investigator Program。; The recalcitrance of pathogens to traditional antibiotics has made treating and eradicating bacterial infections more difficult.In this regard,developing new antimicrobial agents to combat antibiotic-resistant strains...; 关键词：Antimicrobial resistance Antimicrobial peptides Design methods PEPTIDOMIMETICS Artificial intelligence

Peptidomimetic-liganded gold nanoclusters for controlled iron delivery and synergistic suppression of tumor growth: 《Nano Research》2023年第10期12066-12075,共10页Xiqi Ma Duo Cai Zhixiong Zhang Qi Dai Xinyu Li Biao Yu Baosheng Ge Shihai Liu Xiaojuan Wang Fang Huang; the National Natural Science Foundation of China(Nos.22177133,42061134020,and 32070380);the Natural Science Foundation of Shandong Province(Nos.ZR2019ZD17 and ZR2021MH022);the Qingdao Municipal People’s Livelihood Science and Technology Project(No.17-3-3-76-nsh);the Graduate Innovative Engineering Funding project of UPC(No.YCX2020041).; A novel peptidomimetic-liganded gold nanocluster(CDp-AuNC)is proposed for the synergistic suppression of tumor growth.Taking advantages of the multi-capabilities offered by the surface ligands,including iron chelation...; 关键词：SELF-ASSEMBLY drug delivery ferroptosis PEPTIDOMIMETICS gold nanocluster

Photochemical Nitration of Protected Anilines by 5-Methyl-1,4-dinitroimidazole: 《Chinese Journal of Chemistry》2023年第13期1589-1593,共5页Xinlong Fan Yue Zhao Lei Liu Huan Wang; supported by NSF of China(Grant 21922703 and 91953112 to H.W.);the Natural Science Foundation of Jiangsu Province(Grant BK20190004 and BK20202004);National Key R&D Program of China(2019YFA0905800).; Nitroanilines are important building blocks in pharmaceuticals,materials and dyes.Nitration methods for anilines under mild conditions are highly desired.Herein,we report a photochemical method for the nitration of an...; 关键词：ANILINE Nitration Photocatalysis PHOTOCHEMISTRY Dinitroimidazole NITROANILINE PEPTIDOMIMETICS Radical reactions

α/Sulfono-γ-AA peptide hybrids agonist of GLP-1R with prolonged action both in vitro and in vivo: 《Acta Pharmaceutica Sinica B》2023年第4期1648-1659,共12页Yan Shi Candy Lee Peng Sang Zaid Amso David Huang Weixia Zhong Meng Gu Lulu Wei Vân T.B.Nguyen-Tran Jingyao Zhang Weijun Shen Jianfeng Cai; supported by NIH R01AI152416(to Jianfeng Cai,USA);NIH R01 AG056569(to Jianfeng Cai,USA)。; Peptides are increasingly important resources for biological and therapeutic development,however,their intrinsic susceptibility to proteolytic degradation represents a big hurdle.As a natural agonist for GLP-1R,glucag...; 关键词：GLP-1 PEPTIDOMIMETICS Helical structures Stability Type-2 diabetes treatments Rational design GLP-1R agonists Pharmacological activity

Multivalent Display of Lipophilic DNA Binders for Dual-Selective Anti-Mycobacterium Peptidomimetics with Binary Mechanism of Action: 《CCS Chemistry》2022年第11期3573-3586,共14页Jianxue Wang Junfeng Song Xianhui Chen Rey-Ting Guo Yingjie Wang Guopu Huang Nan Zheng Peilei Hu Xinxin Feng Yugang Bai; This research was made possible as a result of the start-up funding from Hunan University,as a part of China’s Fundamental Research Funds for the Central Universities,the funding from the National Natural Science Foundation of China(grant nos.21877033,92163127,Y.B.,21807031,22177031,X.F.);the funding from the Natural Science Foundation of Hunan Province(grant no.2021JJ30088,Y.B.,2020JJ4177,X.F.);the Open Funding Project of the State Key Laboratory of Biocatalysis and Enzyme Engineering(Hubei University,SKLBEE2019003,X.F.).; We made oligoamidine-based peptidomimetics highly specific for mycobacteria eradication by introducing and arraying lipophilic DNA binding motifs on macromolecular backbones.The short poly(amidino-phenylindole)(PAPI)s...; 关键词：PEPTIDOMIMETIC MYCOBACTERIA antimicrobial membrane disruption DNA binding

Editorial of Special Column“Novel Peptides and Peptidomimetics in Drug Discovery”被引量：1: 《Acta Pharmaceutica Sinica B》2021年第9期2606-2608,共3页Jianfeng Cai Lulu Wei; Since insulin,a natural peptide composed of 51 amino acids,was first isolated and commercialized in the 1920s,peptide drugs have greatly reshaped our modern drug discovery area^(1).To date,the total number of approved...; 关键词：DRUGS POPULAR OVERCOME

Editor Profiles: Guest Editors of Special Column “Novel Peptides and Peptidomimetics in Drug Discovery”: 《Acta Pharmaceutica Sinica B》2021年第9期2605-2605,共1页; Prof.Jianfeng Cai obtained B.S.and M.S.in chemistry from the Nanjing University in 1997 and 2000,respectively.He received his Ph.D.in bioorganic chemistry from the University of Washington in St.Louis(USA) in2006.Befo...; 关键词：Profiles GUEST CHEMISTRY

Peptidomimetic-based antibody surrogate for HER2被引量：1: 《Acta Pharmaceutica Sinica B》2021年第9期2645-2654,共10页Mengmeng Zheng Chunpu Li Mi Zhou Ru Jia Fengyu She Lulu Wei Feng Cheng Qi Li Jianfeng Cai Yan Wang; supported by USF start-up fund(Jianfeng Cai);supported by the National Natural Science Foundation of China(Qi Li,81520108031,81573764,81774095);a Municipal Human Resources Development Program for Outstanding Leaders in Medical Disciplines in Shanghai(Qi Li,2017BR031,China);Three-years Plan for the Development of T.C.M(ZY(2018e2020)-CCCX-2003-03,China); Inhibition of human epidermal growth factor receptor 2 mediated cell signaling pathway is an important therapeutic strategy for HER2-positive cancers.Although monoclonal antibodies are currently used as marketed drugs...; 关键词：HER2 ANTI-CANCER PEPTIDOMIMETICS γ-AApeptides Antibody-surrogate

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