吕杨

作品数：2被引量：0H指数：0
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供职机构：北京大学药学院药物化学系更多>>
发文主题：INHIBITORSSYNTHESISINTERMEDIATESEFFICIENTACTIVITY更多>>
发文领域：医药卫生更多>>
发文期刊：《Journal of Chinese Pharmaceutical Sciences》更多>>
所获基金：国家自然科学基金更多>>
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Efficient synthesis of terminal α,β-unsaturated ketones as the intermediates of the proteasome epoxyketone inhibitors via Weinreb amide
《Journal of Chinese Pharmaceutical Sciences》2009年第1期33-36,共4页吕杨 邹晓民 牟科 傅翌秋 马超 周博 徐萍 
National Natural Science Foundation of China (Grant No. 30772650 and 20772008)
Peptidyl epoxyketones were potential antitumor agents due to their 20S proteasome inhibitory activities. Based on their structures and special inhibitory mechanism, a series of compounds were designed by linking the e...
关键词：Epoxyketone SYNTHESIS α β-Unsaturated ketone Weinreb amide 
Synthesis and activity of hydroxyethylene peptidomimetic inhibitors of humanβ-secretase
《Journal of Chinese Pharmaceutical Sciences》2008年第3期215-220,共6页马超 王月华 杨晓鸣 邹晓民 吕杨 杜冠华 徐萍 
National Natural Science Foundation of China(Grant No.30772650 and 20772008).
A series of β-secretase peptidomimetic inhibitors with Leu＊Ala hydroxyethylene dipeptide isostere were synthesized and their β-secretase inhibitory activities were measured. The most potent compound N9 showed an in...
关键词：β-Secretase inhibitors Hydroxyethylene isostere SYNTHESIS Bioactivity 
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