傅翌秋

作品数：5被引量：0H指数：0
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供职机构：北京大学药学院药物化学系更多>>
发文主题：SYNTHESISINHIBITORSINTERMEDIATESFOUREFFICIENT更多>>
发文领域：医药卫生更多>>
发文期刊：《Journal of Chinese Pharmaceutical Sciences》更多>>
所获基金：国家自然科学基金国家科技部专项基金国家重点基础研究发展计划更多>>
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Efficient synthesis of terminal α,β-unsaturated ketones as the intermediates of the proteasome epoxyketone inhibitors via Weinreb amide
《Journal of Chinese Pharmaceutical Sciences》2009年第1期33-36,共4页吕杨 邹晓民 牟科 傅翌秋 马超 周博 徐萍 
National Natural Science Foundation of China (Grant No. 30772650 and 20772008)
Peptidyl epoxyketones were potential antitumor agents due to their 20S proteasome inhibitory activities. Based on their structures and special inhibitory mechanism, a series of compounds were designed by linking the e...
关键词：Epoxyketone SYNTHESIS α β-Unsaturated ketone Weinreb amide 
Synthesis of protected aminoalkyl sulfinyl dilactones from α-amino acids
《Journal of Chinese Pharmaceutical Sciences》2007年第2期119-124,共6页付刚 邹晓民 傅翌秋 牟科 马超 吕扬 徐萍 
National Natural Science Foundation of China(20572006);985 Program,Ministry of Education of China
Aim To synthesize protected aminoalkyl sulfinyl dilactones which were useful as the synthetic intermediates or the Cterminal pharmacophores of potential peptidomimetic proteasome inhibitors. Methods Organic reactions ...
关键词：Proteasome inhibitors Protected aminoalkyl sulfmyl dilactone  Synthesis 
Synthesis of Hydroxyethylene-based β-Secretase Inhibitors
《Journal of Chinese Pharmaceutical Sciences》2006年第2期101-108,共8页杨晓鸣 邹晓民 傅翌秋 牟科 徐萍 
National Natural Science Foundation of China(20272004 and 20572006);985 Program, Min-istry of Education of China.
Aim To discuss in depth the synthesis of hydroxyethylene dipeptide-based β-secretase inhibitors; Methods Organic reactions such as nucleophilic addition and substitution assisted by organometallic agents, catalytic h...
关键词：Β-SECRETASE PEPTIDOMIMETICS hydroxyethylene dipeptide isostere SYNTHESIS 
Template Synthesis of CPP32 Inhibitors by Ugi Four-Component Condensation Reaction
《Journal of Chinese Pharmaceutical Sciences》2004年第4期238-241,共4页张欣 邹晓民 傅翌秋 杨晓鸣 牟科 徐萍 
NationalNaturalScienceFoundationofChina(2 0 2 72 0 0 4) .
To find a reasonable way to prepare the designed CPP32 inhibitors. Method Ugifour-component condensation reaction was used to synthesize peptide mimic CPP32 inhibitors; ResultsA key isocyanide component (aspartate-der...
关键词：CPP32 Ugi-4CR ISOCYANIDE 
Synthesis of Boc-Asp(OBzl)-β-Ala-Asp(OBzl)-N(OMe)Me as a Useful Precursor of Aspartyl Peptide Aldehyde Derivatives
《Journal of Chinese Pharmaceutical Sciences》2003年第3期123-126,共4页邹晓民 赵宏 傅翌秋 张欣 徐萍 
SupportedbytheNationalNaturalScienceFoundationofChina (2 0 2 72 0 04,20342003)andtheNationalMajorProgramforBasicResearchDevelopment(project973)fromtheMinistryofScienceandTechn ologyofChina (G19980 5 1114 )
Aim To synthesize the tripepide Weinreb amide Boc Asp(OBzl) β Ala Asp(OBzl) N(OMe)Me (7) as a useful precursor of aspartyl peptide aldehyde derivatives; Methods DCC, IBCF method was used for preparation of ...
关键词：Weinreb amide aspartyl peptide aldehyde Boc protecting group activated ester 
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