Β-SECRETASE

作品数：27被引量：32H指数：4
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相关领域：医药卫生更多>>
相关作者：杨晓鸣邹晓民徐萍刘飞扬赖燕来更多>>
相关机构：北京大学中国医学科学院北京协和医学院中国药科大学首都医科大学宣武医院更多>>
相关期刊：《Advances in Bioscience and Biotechnology》《Acta Biochimica et Biophysica Sinica》《Science China(Life Sciences)》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金广东省自然科学基金北京市自然科学基金广西壮族自治区自然科学基金更多>>
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BACE1 inhibitors:A promising therapeutic approach for the management of Alzheimer’s disease
《Asian Pacific Journal of Tropical Biomedicine》2024年第9期369-381,共13页Richa Arya Smita Jain Sarvesh Paliwal Kirtika Madan Swapnil Sharma Achal Mishra Prashant Tiwari Sunil Kumar Kadiri 
Alzheimer’s disease is a neurological disorder marked by the accumulation of amyloid beta(Aβ)aggregates,resulting from mutations in the amyloid precursor protein.The enzymeβ-secretase,also known asβ-site amyloid p...
关键词：BACE1 inhibitors Amyloid precursor protein Β-SECRETASE Structure-based drug design 3D-QSAR β-amyloid precursor protein 
Resveratrol and Sir2 Reverse Sleep and Memory Defects Induced by Amyloid Precursor Protein
《Neuroscience Bulletin》2023年第7期1117-1130,共14页Yuping Hao Lingzhan Shao Jianan Hou Yan Zhang Yuqian Ma Jinhao Liu Chuan Xu Fujun Chen Li-Hui Cao Yong Ping 
funded by grants from the National Natural Science Foundation of China(81970999);the Shanghai Rising-Star Program(19QA1404900);the Innovation Program of the Shanghai Municipal Education Commission(2019-01-07-00-02-E00037).
Resveratrol(RES),a natural polyphenolic phytochemical,has been suggested as a putative anti-aging molecule for the prevention and treatment of Alzheimer’s disease(AD)by the activation of sirtuin 1(Sirt1/Sir2).In this...
关键词：RESVERATROL SIR2 SLEEP Amyloid precursor protein Β-SECRETASE DROSOPHILA 
Critical thinking on amyloid-beta-targeted therapy:challenges and perspectives被引量：8
《Science China(Life Sciences)》2021年第6期926-937,共12页Bin-Lu Sun Yang Chen Dong-Yu Fan Chi Zhu Fan Zeng Yan-Jiang Wang 
supported by the National Natural Science Foundation of China(91749206,81930028,81625007,81870860,31921003)。
Amyloid-beta(Aβ)plays a pivotal role in the pathogenesis of Alzheimer's disease(AD)and has been regarded as the main therapeutic target for AD.However,most of the Aβ-targeted clinical trials have not succeeded.There...
关键词：Alzheimer's disease amyloidβ immunotherapy Β-SECRETASE Γ-SECRETASE enzyme inhibitor multi-target therapy tertiary prevention strategy 
Inhibition of BACE1, the β-secretase implicated in Alzheimer’s disease, by a chondroitin sulfate extract from Sardina pilchardus被引量：4
《Neural Regeneration Research》2020年第8期1546-1553,共8页Courtney J.Mycroft-West Anthony J.Devlin Lynsay C.Cooper Patricia Procter Gavin J.Miller David G.Fernig Marco Guerrini Scott E.Guimond Marcelo A.Lima Edwin A.Yates Mark Andrew Skidmore 
financially supported by grants from the Engineering and Physical Sciences Research Council,UK,the Biotechnology and Biological Sciences Research Council,UK,the Medical Research Council,UK,Intellihep Ltd.,UK,MI Engineering Ltd.,UK and Financiadora de Estudos e Projetos
The pharmaceutical and anticoagulant agent heparin,a member of the glycosaminoglycan family of carbohydrates,has previously been identified as a potent inhibitor of a key Alzheimer’s disease drug target,the primary n...
关键词：amyloid-β aspartyl protease carbohydrates galactosaminoglycans heparan sulfate HEPARIN marine polysaccharide pilchards SARDINES THERAPEUTICS 
Purification of Full-Length <i>β</i>-Secretase Involved in Alzheimer’s Disease, and Proteomic Identification of Binding Partners
《Journal of Biomedical Science and Engineering》2020年第1期1-12,共12页Lucy Ly Richard Parsons Brian Austen 
β-Secretase (BACE1 or β-site APP cleaving enzyme) is an acid protease that releases the neurotoxic 40 - 42 residue peptides (β-amyloid or A-β) from its glycoprotein precursor, (APP or amyloid precursor protein) wh...
关键词：Alzheimer’s Disease β-Amyloid Β-SECRETASE PURIFICATION Protein Complex Endoplasmic Reticulum Proteomics 
Computational Assessment and Pharmacological Property Breakdown of Eight Patented and Candidate Drugs against Four Intended Targets in Alzheimer’s Disease
《Advances in Bioscience and Biotechnology》2019年第11期405-430,共26页Bishajit Sarkar Syed Sajidul Islam Md. Asad Ullah Sohana Hossain Md. Nazmul Islam Prottoy Yusha Araf Masuma Afrin Taniya 
Alzheimer’s Disease (AD) is the most prevalent age-related dementia. AD can be caused by abnormal processing of amyloid precursor protein (APP) or by oxidative stress or may be due to the actions of kinases or the de...
关键词：Alzheimer’s Disease Harmol Β-SECRETASE DOCKING Tau Protein Β-AMYLOID 
Physalin B reduce secretion of Aβ by inhibiting phosphorylation of STAT3 via down-regulated expression of β-secretase and γ-secretase
《中国药理学与毒理学杂志》2019年第6期426-427,共2页BAI Shan-shan ZHUO Lin SUN Yi SHI Ru-ling XIE Yong-sheng ZHANG Wei 
National Natural Science Foundation(U1604108);Key Science and Technology Program of Henan Province(152102310112; 162102310121);National Training Program of Innovation for Undergraduates(201710472009)
OBJECTIVE Extracellular amyloid-β(Aβ) plaques are one of the major pathological hallmarks of Alzheimer disease(AD). Therefore, decreasing Aβ levels is one strategyfor preventing the etiology of AD. Aβ peptides are...
关键词：Alzheimer disease PHYSALIN B Β-AMYLOID protein BACE1 PS1 STAT3 
Multitarget therapeutic strategies for Alzheimer's disease被引量：11
《Neural Regeneration Research》2019年第3期437-440,共4页Mostafa M.Ibrahim Moustafa T.Gabr 
Neurodegenerative diseases such as Alzheimer's, Huntington's and Parkinson's diseases have multifaceted nature because of the different factors contributing to their progression. The complex nature of neurodegenerativ...
关键词：multitarget-directed LIGANDS ACETYLCHOLINESTERASE Β-SECRETASE Alzheimer's disease HYBRIDIZATION NEURODEGENERATIVE diseases TACRINE brain permeability 
α-secretase ADAM IO physically interacts with β-secretase BACE1 in neurons and regulates CHL1 proteolysis被引量：3
《Journal of Molecular Cell Biology》2018年第5期411-422,共12页Xin Wang Congcong Wang Gang Pei 
α-secretase and β-secretase are known to compete for amyloid precursor protein （APP） processing and thus play a vital role in Alzheimer＇s disease pathogenesis. A disintegrin and metaUoproteinase 10 （ADAM10） and...
关键词：SECRETASE Alzheimer＇s disease ADAM10 BACE1 interact APP CHL1 
Iron dysregulates APP processing accompanying with sAPPα cellular retention and β-secretase inhibition in rat cortical neurons
《Acta Pharmacologica Sinica》2018年第2期177-183,共7页Yu-ting CHEN Wu-yan CHEN Xiao-tian HUANG Ye-chun XU Hai-yan ZHANG 
The authors are grateful to the National Natural Science Foundation of China （No 81522045 and 31400932）.
Amyloid precursor protein （APP） and iron both play pivotal roles in the central nervous system, but whether and how iron influences the processing of endogenous APP in neurons remain unclear. Here, we investigated t...
关键词：IRON NEURONS amyloid precursor protein sAPPα Β-AMYLOID Β-SECRETASE Atzheimer＇s disease 
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