云南高校图书馆联盟文献共享服务平台- TACRINE

TACRINE: 作品数：20被引量：43H指数：3; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：李之望陈忠郑少萍樊友珍陈季强更多>>; 相关机构：华中科技大学浙江大学中南民族大学中国科学院更多>>; 相关期刊：《International Journal of Ophthalmology(English edition)》《美国医学会杂志（中文版）》《中国生物学文摘》《华中科技大学学报（医学版）》更多>>; 相关基金：国家自然科学基金湖北省科技计划项目海南省教育厅科研基金更多>>

Multitarget therapeutic strategies for Alzheimer's disease被引量：11: 《Neural Regeneration Research》2019年第3期437-440,共4页Mostafa M.Ibrahim Moustafa T.Gabr; Neurodegenerative diseases such as Alzheimer's, Huntington's and Parkinson's diseases have multifaceted nature because of the different factors contributing to their progression. The complex nature of neurodegenerativ...; 关键词：multitarget-directed LIGANDS ACETYLCHOLINESTERASE Β-SECRETASE Alzheimer's disease HYBRIDIZATION NEURODEGENERATIVE diseases TACRINE brain permeability

The protective role of tacrine and donepezil in the retina of acetylcholinesterase knockout mice: 《International Journal of Ophthalmology(English edition)》2015年第5期884-890,共7页Yun-Min Yi Li Cai Yi Shao Man Xu Jing-Lin Yi; Supported by National Natural Science Foundation of China(No.81160118,81400372);Clinical Medicine Research Special-purpose Foundation of China(No.L2012052);Jiangxi Province Sailing Engineering(No.2014022);Science Technology Foundation of Jiangxi Province(No.20151BBG70223);Youth Science Foundation of Jiangxi Province(No.20151BAB215016);Education Department Youth Scientific Research Foundation(No.GJJ14170);Health Development Planning Commission Science Foundation of Jiangxi Province(NO:20155154);Health Department Tradition Chinese Medicine Science and Technology Foundation(No.2010A015,2012A139,2013A073); AIM: To determine the effect of different concentrations of the acetylcholinesterase (AChE) inhibitors tacrine and donepezil on retinal protection in AChE(+/-) mice (AChE knockout mice) of various ages. METHODS: Cultu...; 关键词：retinal pigment epithelium ACETYLCHOLINESTERASE apoptosis AChE(+/-) animal models acetylcholinesterase inhibitors

Bis(7)-tacrine/tacrine对大鼠DRG神经元延时整流钾通道电流的调制作用: 《中国药理学通报》2012年第2期195-200,共6页李享元李之望; 国家自然科学基金资助(No 30973961); 目的研究乙酰胆碱酯酶抑制剂bis(7)-tacrine/tac-rine[bis(7)-tetrahydroaminacrine]对大鼠DRG神经元的延时整流钾通道电流的调制作用。方法在急性分离的DRG神经元标本上,采用全细胞膜片钳技术记录钾通道电流,研究bis(7)-tacrine/tacrin...; 关键词：延时整流钾电流 bis(7)-tacrine TACRINE 抑制背根神经结神经保护

新型tacrine双联体对培养大鼠海马神经元NMDA受体作用位点的研究: 《江汉大学学报（自然科学版）》2011年第3期61-66,共6页刘宇炜李超英; 湖北省科技计划自然科学基金重点项目(2008CDA053); 目的:研究新型tacrine双联体bis(7)-tacrine对NMDA受体的作用位点.方法:大鼠海马神经元原代培养,全细胞膜片钳记录培养大鼠海马神经元上NMDA激活电流变化.结果:细胞外液pH值从8.1改变到6.7,在细胞外液中加入二硫苏糖醇(2 mmol/L)、精胺(...; 关键词：bis(7)-tacrine NMDA 海马二硫苏糖醇精胺镁锌 MK-801

Synthesis and THF Accompanied Crystal Structure of 11H-Naphtho[1',2':5,6]- pyrano[2,3-d]pyrimidin-11(10H)-one: 《Chinese Journal of Structural Chemistry》2008年第12期1469-1474,共6页张立军杨希泉李加荣史大昕张玲范妍秋; supported by the Beijing Institute of Technology (No.20060542021); 8,9,12-Trihydro-9,9-pentamethylene- 12-（3-nitrophenyl）- 11H-naphtho[ 1＇,25,6]- pyrano[2,3-d]pyfimidin- 11 （10H）-one 1, another conversion product of Ffiedlandler reaction, has been synthesized by the reaction of ...; 关键词：SYNTHESIS crystal structure tacrine analogue X-ray crystallography

Synthesis of 2H-3,1-pyrazolo[3,4-e]oxazines via a new conversion of Friedlander reaction: 《Chinese Chemical Letters》2007年第6期636-638,共3页Li, Jia Rong Zhang, Li Jun Chen, Jin Nan Yang, Xi Quan Wang, Li Jun Zhao, Xiao Fan Qiu, Jun Xia; 2H-3,l-Pyrazolo[3,4-e]oxazines (5a-c) and tacrine analogies (6a-c) were designed and prepared using 5-amino-4-cyanopyrazole (7) and cycloketones (2a-c) as reactants. The study demonstrated that the new conversion exis...; 关键词：PYRAZOLE OXAZINES TACRINE CYCLOCONDENSATION SYNTHESIS

Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice： additivity with huperzine A and relative potency to tacrine被引量：3: 《中国生物学文摘》2006年第10期16-16,共1页Xu Z Zheng H Law SL Dong So D Han Y Xue H; 关键词：阿耳茨海默氏病早老性痴呆石杉碱甲记忆力缩氨酸认知能力脑损伤

Tacrine对大鼠三叉神经节神经元5-HT激活电流的调制作用: 《华中科技大学学报（医学版）》2006年第3期291-293,共3页郑少萍罗加烈刘长金郑少江樊友珍李之望; 海南省教育厅科研基金资助项目(No.HJ200603); 目的研究他可林（tacrine）对急性分离的大鼠三叉神经节神经元5-HT。受体的调制作用，探讨tacrine治疗阿尔茨海默病新的可能途径。方法采用全细胞膜片钳技术记录急性分离的三叉神经节神经元膜5-HT。受体介导的电流。结果 83．75％（67...; 关键词：他可林 5 -HT3受体全细胞膜片钳记录三叉神经节

Tetrahydroacridine inhibits voltage-dependent Na^+ current in guinea-pig ventricular myocytes: 《Acta Pharmacologica Sinica》2004年第9期1138-1144,共7页WeiWANG Yi-pingWANG Guo-yuanHU; ProjectsupportedbyagrantfromtheNationalNaturalScienceFoundationofChina(30123005); AIM: To study the effects of tetrahydroacridine (tacrine) on voltage-gated Na+ channels in cardiac tissues. METHODS: Single ventricular myocytes were enzymatically dissociated from adult guinea-pig heart. Voltage-depe...; 关键词：Alzheimer disease cholinesterase inhibitors sodium channels tetrahydroacridine (tacrine) MYOCARDIUM patch-clamp techniques

Acute effects of huperzine A and tacrine on rat liver被引量：1: 《Acta Pharmacologica Sinica》2003年第3期247-250,共4页马小超欣坚王海学张婷屠曾宏; AIM: To observe the acute effects of huperzine A and tacrine on rat liver. METHODS: Changes of liver coefficient,serum biochemistry, and histopathology were detected after single dose. In vitro cytotoxicity was assess...; 关键词：cholinesterase inhibitors huperzine A TACRINE LIVER acute toxicity test

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