Γ-SECRETASE

作品数：23被引量：59H指数：5
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相关领域：医药卫生更多>>
相关作者：殷莹曹鹏缪凤琴于春泳梁国标更多>>
相关机构：东南大学清华大学第二军医大学台湾大学更多>>
相关期刊：《National Science Review》《Advances in Bioscience and Biotechnology》《Acta Biochimica et Biophysica Sinica》《Medicinal Plant》更多>>
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Potential Mechanism of Huanglian Jiedu Decoction Regulating Iron Homeostasis in NLRP3/IFITM3/γ-secretase Pathway against AD Based on Network Pharmacology
《Medicinal Plant》2025年第2期35-39,共5页Ye CHU Yingyuan QIN Suyi CHEN Linhao LIU Mengjia LI Huanjin HUANG Liuyi WEI Yanyuan ZHOU Linglin CHEN Yifei CHEN 
Supported by National Natural Science Foundation of China(82160832);Natural Science Foundation of Guangxi Zhuang Autonomous Region(2022GXNSFAA035603&2017GXNSFAA198255);the Open Project Program of Guangxi Key Laboratory of Brain and Cognitive Neuroscience,Guilin Medical University(GKLBCN-202206-02);the Fourth Training Plan of Thousands of Young and Mid-aged Mainstay Teachers in Guangxi Colleges and Universities.
[Objectives]To explore the possible targets of Huanglian Jiedu Decoction in NLRP3/IFITM3/γ-secretase pathway through regulating iron homeostasis and the potential mechanism of anti-Alzheimer s disease(AD).[Methods]Fi...
关键词：Huanglian Jiedu Decoction Iron homeostasis Action mechanism Alzheimer's disease(AD) Network pharmacology 
Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease
《Neural Regeneration Research》2025年第1期174-180,共7页Yinglong Miao Michael S.Wolfe 
supported in part by Award 2121063 from National Science Foundation(to YM);AG66986 from the National Institutes of Health(to MSW).
γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the ...
关键词：Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics NOTCH 
CNTNAP2 intracellular domain(CICD)generated byγ-secretase cleavage improves autism-related behaviors被引量：2
《Signal Transduction and Targeted Therapy》2023年第7期3415-3426,共12页Jing Zhang Fang Cai Renbin Lu Xiaoliang Xing Lu Xu Kunyang Wu Zishan Gong Qing Zhang Yun Zhang Mengen Xing Weihong Song Jia-Da Li 
This work was supported by funding from National Natural Science Foundation of China(NSFC),Grant/Award Number:81770780 and 31972913;Key Research and Development Programs from Hunan Province,Grant/Award Number:2021DK2001;Guangdong Key Project in‘Development of New Tools for Diagnosis and Treatment of Autism’,Grant/Award Number:2018B030335001;Strategic Priority Research Program of Central South University,Grant/Award Number:ZLXD2017004;The project has been funded in part with Independent Exploration and Innovation Project of Central South University,Grant/Award Number:2018zzts393.
As the most prevalent neurodevelopmental disorders in children,autism spectrum disorders(ASD)are characterized by deficits in language development,social interaction,and repetitive behaviors or inflexible interests.Co...
关键词：BEHAVIORS CLEAVAGE RESIDUES 
Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease
《Neural Regeneration Research》2022年第1期31-37,共7页Mercedes A.Hernández-Sapiéns Edwin E.Reza-Zaldívar Ana L.Márquez-Aguirre Ulises Gómez-Pinedo Jorge Matias-Guiu Ricardo R.Cevallos Juan C.Mateos-Díaz Víctor J.Sánchez-González Alejandro A.Canales-Aguirre 
supported by the Consejo Nacional de Ciencia y Tecnología Scholarship 711893(to MAH)and 711874(to EER)。
The presenilin genes(PSEN1 and PSEN2)are mainly responsible for causing early-onset familial Alzheimer’s disease,harboring~300 causative mutations,and representing~90%of all mutations associated with a very aggressiv...
关键词：familial Alzheimer’s disease familial Alzheimer’s disease-induced pluripotent stem cells models induced pluripotent stem cells neurogenesis neuronal differentiation Notch presenilin 1 PSEN1 mutations γ-secretase complex 
Critical thinking on amyloid-beta-targeted therapy:challenges and perspectives被引量：8
《Science China(Life Sciences)》2021年第6期926-937,共12页Bin-Lu Sun Yang Chen Dong-Yu Fan Chi Zhu Fan Zeng Yan-Jiang Wang 
supported by the National Natural Science Foundation of China(91749206,81930028,81625007,81870860,31921003)。
Amyloid-beta(Aβ)plays a pivotal role in the pathogenesis of Alzheimer's disease(AD)and has been regarded as the main therapeutic target for AD.However,most of the Aβ-targeted clinical trials have not succeeded.There...
关键词：Alzheimer's disease amyloidβ immunotherapy Β-SECRETASE Γ-SECRETASE enzyme inhibitor multi-target therapy tertiary prevention strategy 
Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects被引量：4
《Frontiers of Medicine》2019年第4期427-437,共11页Zhen Wang Jianhui Wu Xiuyun Tian Chunyi Hao 
We would like to thank all faculty members who assisted us in this study. This work was supported by the Beijing Municipal Administration of Hospitals Clinical Medicine Development Special Funding Support (No. XMLX201708);the Capital Health Research and Development Special Funds (No. 2016-2-2151);Beijing Municipal Administration of Hospitafs Ascent Plan (No. DFL20181104);the National Natural Science Foundation of China (No. 31770836).
Desmoid-type fibromatosis (DF) is a rare monoclonal fibroblastic proliferation that is characterized by locally infiltrative but rarely metastatic lesions. Tyrosine kinase and γ-secretase inhibitors are primarily use...
关键词：targeted therapy desmoid-type FIBROMATOSIS TYROSINE KINASE INHIBITOR Γ-SECRETASE INHIBITOR 
Physalin B reduce secretion of Aβ by inhibiting phosphorylation of STAT3 via down-regulated expression of β-secretase and γ-secretase
《中国药理学与毒理学杂志》2019年第6期426-427,共2页BAI Shan-shan ZHUO Lin SUN Yi SHI Ru-ling XIE Yong-sheng ZHANG Wei 
National Natural Science Foundation(U1604108);Key Science and Technology Program of Henan Province(152102310112; 162102310121);National Training Program of Innovation for Undergraduates(201710472009)
OBJECTIVE Extracellular amyloid-β(Aβ) plaques are one of the major pathological hallmarks of Alzheimer disease(AD). Therefore, decreasing Aβ levels is one strategyfor preventing the etiology of AD. Aβ peptides are...
关键词：Alzheimer disease PHYSALIN B Β-AMYLOID protein BACE1 PS1 STAT3 
Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models被引量：1
《Translational Neurodegeneration》2019年第1期433-449,共17页Inger Lauritzen Anaïs Bécot Alexandre Bourgeois Raphaëlle Pardossi-Piquard Maria-Grazia Biferi Martine Barkats Fréderic Checler 
This work has been developed and supported through the LABEX(excellence laboratory,program investment for the future)DISTALZ(Development of lnnovative Strategies for a Transdisciplinary approach to ALZheimers disease)and by Fondation Alzheimer.A.Be and A.Bo were granted from DISTALZ.
Background:We recently demonstrated an endolysosomal accumulation of theβ-secretase-derived APP C-terminal fragment(CTF)C99 in brains of Alzheimer disease(AD)mouse models.Moreover,we showed that the treatment with th...
关键词：Extracellular vesicles C99 APP-CTFs Homo-and hetero-oligomerization ENDOSOMES LYSOSOMES trans-Golgi network SorLA γ-Secretase inhibition Presenilin knockout Alzheimer’s disease 
Defining the minimum substrate and charge recognition model of gamma-secretase
《Acta Pharmacologica Sinica》2017年第10期1412-1424,共13页Yan YAN Ting-Hai XU Karsten MELCHER H Eric XU 
γ-Secretase is an intramembrane aspartyl protease that cleaves the C99 fragment of amyloid precursor protein to generate extracellular Aβ peptides. These peptides can oligomerize and aggregate to form amyloid plaque...
关键词：Alzheimer＇s disease amyloid beta （Aβ） amyloid precursor protein （APP） C99  γ-secretase minimum substrate Notchprotein recognition model 
Huannao Yicong Formula (还脑益聪方) Regulates γ-Secretase Activity through APH-1 and PEN-2 Gene Raguiation Pathways in Hippocampus of APP/PS1 Double Transgenic Mice被引量：5
《Chinese Journal of Integrative Medicine》2017年第4期270-278,共9页WANG Zhi-yong LIU Jian-gang WEI Yun LIU Mei-xia WANG Qi LIANG Lin YANG Hui-min LI Hao 
Supported by the National Natural Science Foundation of China(No.81173383 and No.81573819);Beijing Municipal Science and Technology Plan "Ten Disease and Ten Medicine"(No.Z141100002214003)
Objective To observe the effects of Huannao Yicong Formula (还脑益聪方, HYF) on learning and memory and it’s regulating effect on γ-secretase related anterior pharynx defective 1 (APH-1), presenilin enhancer-2 (PEN-...
关键词：Huannao Yicong Formula Alzheimer’s disease Γ-SECRETASE Β-AMYLOID 
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