PHYSALIN

作品数：7被引量：10H指数：2
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相关领域：医药卫生更多>>
相关作者：张浩王慧中罗建光孔令义张斯雯更多>>
相关机构：杭州师范大学中国药科大学吉林大学成都中医药大学更多>>
相关期刊：《杭州师范大学学报（自然科学版）》《中药与临床》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》更多>>
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HPLC-CAD法测定锦灯笼中3个酸浆苦素类成分的含量
《中药与临床》2023年第2期23-25,32,共4页张传洋 曾利 杨璐嘉 王丽娟 邓放 
四川省科技厅重点研发项目(No.2022YFN0068);成都中医药大学“杏林学者”学科人才科研提升计划(No.030055062)。
目的:建立HPLC-CAD法同时测定锦灯笼中physalin F、physalin H、physalin B三个成分含量的方法。方法:采用Thermo Hypersil GOLD C18色谱柱(250 mm×4.6 mm,5μm),以乙腈(A)-水(B)为流动相,梯度洗脱(0—8 min,32%~38%A;8—20 min,38%~45...
关键词：锦灯笼 HPLC-CAD Physalin F Physalin H Physalin B 
Physalin B reduces Aβ secretion through down-regulation of BACE1 expression by activating FoxO1 and inhibiting STAT3 phosphorylation被引量：2
《Chinese Journal of Natural Medicines》2021年第10期732-740,共9页ZHANG Wei BAI Shan-Shan ZHANG Qi SHI Ru-Ling WANG He-Cheng LIU You-Cai NI Tian-Jun WU Ying YAO Zhao-Yang SUN Yi WANG Ming-Yong 
supported by the National Natural Science Foundation(No.U1604108);Key Science and Technology Program of Henan Province(Nos.202102310020 and 182102311148);the Program for Innovative Research Team(in Science and Technology)in University of Henan Province(No.20IRTSTHN030);the Graduate Scientific Research Innovation Support Project of Xinxiang Medical University(No.YJSCX201866Y).
Physalin B(PB),one of the major active steroidal constituents of Solanaceae Physalis plants,has a wide variety of biological activities.We found that PB significantly down-regulatedβ-amyloid(Aβ)secretion in N2a/APPs...
关键词：Physalin B Β-AMYLOID BACE1 FOXO1 Alzheimer’s disease 
UPLC-MS/MS法测定苦蘵宿萼中physalin H和physalin D的含量
《杭州师范大学学报（自然科学版）》2021年第4期360-363,448,共5页王灵艳 戴亚平 薛洁 俞春娜 王慧中 展晓日 
国家自然科学基金项目(32000255,31970346);国家级大学生创新创业训练计划项目(201910346058);浙江省大学生科技创新活动计划(新苗人才计划)项目(2020R427036,2019R426027).
建立了同时测定苦蘵中2种酸浆苦味素类化合物含量的方法.应用超高效液相色谱(UPLC)与Qtrap质谱(MS)联用同时测定苦蘵中酸浆苦味素H(physalin H)和酸浆苦味素D(physalin D)2个成分的含量.采用Waters Acquity BEH C18(100 mm×2.1 mm,1.7...
关键词：苦蘵 酸浆苦味素 液质联用 含量测定 
Physalin B reduce secretion of Aβ by inhibiting phosphorylation of STAT3 via down-regulated expression of β-secretase and γ-secretase
《中国药理学与毒理学杂志》2019年第6期426-427,共2页BAI Shan-shan ZHUO Lin SUN Yi SHI Ru-ling XIE Yong-sheng ZHANG Wei 
National Natural Science Foundation(U1604108);Key Science and Technology Program of Henan Province(152102310112; 162102310121);National Training Program of Innovation for Undergraduates(201710472009)
OBJECTIVE Extracellular amyloid-β(Aβ) plaques are one of the major pathological hallmarks of Alzheimer disease(AD). Therefore, decreasing Aβ levels is one strategyfor preventing the etiology of AD. Aβ peptides are...
关键词：Alzheimer disease PHYSALIN B Β-AMYLOID protein BACE1 PS1 STAT3 
Physalin B not only inhibits the ubiquitin-proteasome pathway but also induces incomplete autophagic response in human colon cancer cells in vitro被引量：5
《Acta Pharmacologica Sinica》2015年第4期517-527,共11页Yi-ming MA Wei HAN Jia LI Li-hong HU Yu-bo ZHOU 
This work was supported by grants from the National Natu- ral Science Foundation of China （No 81473244, 81270942, and 81125023）, and the National Science and Technology Major Projects for “Major New Drugs Innovation and Development” （2012ZX09301001-004, 2013ZX09508104）.
Aim： To investigate the effects of physalin B insolated from Physalis divericata on human colon cancer cells in vitro and its anticancer mechanisms. Methods： Human HCT116 colon cancer cell line was tested. Cell viab...
关键词：physalin B Physalis angulata L HCT116 colon cancer cells autophagy reactive oxygen species p38 mitogen-activatedprotein kinases microtubule-associated proteins apoptosis UBIQUITINS N-acetyI-L-cysteine 
Extraction and Crystal Structure of Physalin B被引量：1
《Chinese Journal of Structural Chemistry》2014年第5期795-800,共6页杨海军 沙聪威 陈梅果 胡玲 
Supported by the Guangdong Provincial Science and Technology Projects(No.2011B031700072);Guangdong Natural Science Foundation(No.9151063201000036,S2013010013484);Guangdong Provincial Administration of traditional Chinese medicine project(No.2008435)
The title compound of physalin B（C28H32O9）, a main active physalin of Physalis angulata L, was isolated from the whole plant of Physalis angulata L, and characterized by X-ray diffraction analysis. It crystallizes i...
关键词：physalin B crystal structure Physalis angulata L PHYSALIN 
Three new physalins from Physalis alkekengi var. franchetii被引量：2
《Natural Products and Bioprospecting》2013年第3期103-106,共4页Wan-Xuan XU Jian-Chao CHEN Jie-Qing LIU Lin ZHOU Yi-Fen WANG Ming-Hua QIU 
This project was financially supported by the National Major Basic Research Program(No.SB2007FY400);the National Ministry of Science and Technology of China,the National Knowledge Innovation Program of Chinese Academy of Sciences(No.KSCX2-YW-G-038);the Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China(P2010-ZZ14).
Three new physalin steroids,physalin Ⅲ(1),physalin IV(2),3-O-methylphysalin X(3),together with five known physalins(4-8)were isolated from the 80%EtOH extract of calyces of Physalis alkekengi var.franchetii.The struc...
关键词：Physalis alkekengi var.franchetii STEROID PHYSALIN neophysalin 
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