UBIQUITINS

作品数：2被引量：5H指数：1
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Chemical Synthesis of Structurally Defined Phosphorylated Ubiquitins Suggests Impaired Parkin Activation by Phosphorylated Ubiquitins with a Non-Phosphorylated Distal Unit
《CCS Chemistry》2019年第5期476-489,共14页Man Pan Qingyun Zheng Shuai Gao Qian Qu Yuanyuan Yu Ming Wu Huan Lan Yulei Li Sanling Liu Jiabin Li Demeng Sun Lining Lu Tian Wang Wenhao Zhang Jiawei Wang Yiming Li Hong-Gang Hu Changlin Tian Lei Liu 
We thank the National Key R&D Program of China(2017YFA0505200,2016YFA0400903,and 2015CB910103);National Science Foundation of China(91753205,21532004,21761142008,81621002,21621003,91849129,and 21708036)for their financial support.
Mutations in genes encoding PINK1(PTEN-induced kinase 1)and Parkin(E3 ubiquitin ligase)are identified in familial Parkinson’s disease.However,it remains unclear whether the phosphorylated Ub chains activate wild-type...
关键词：chemical protein synthesis UBIQUITIN phosphorylation PARKIN mitochondrial autophagy 
Physalin B not only inhibits the ubiquitin-proteasome pathway but also induces incomplete autophagic response in human colon cancer cells in vitro被引量：5
《Acta Pharmacologica Sinica》2015年第4期517-527,共11页Yi-ming MA Wei HAN Jia LI Li-hong HU Yu-bo ZHOU 
This work was supported by grants from the National Natu- ral Science Foundation of China （No 81473244, 81270942, and 81125023）, and the National Science and Technology Major Projects for “Major New Drugs Innovation and Development” （2012ZX09301001-004, 2013ZX09508104）.
Aim： To investigate the effects of physalin B insolated from Physalis divericata on human colon cancer cells in vitro and its anticancer mechanisms. Methods： Human HCT116 colon cancer cell line was tested. Cell viab...
关键词：physalin B Physalis angulata L HCT116 colon cancer cells autophagy reactive oxygen species p38 mitogen-activatedprotein kinases microtubule-associated proteins apoptosis UBIQUITINS N-acetyI-L-cysteine 
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