CNTNAP2 intracellular domain(CICD)generated byγ-secretase cleavage improves autism-related behaviors  

作　　者：Jing Zhang Fang Cai Renbin Lu Xiaoliang Xing Lu Xu Kunyang Wu Zishan Gong Qing Zhang Yun Zhang Mengen Xing Weihong Song Jia-Da Li 

机构地区：[1]Furong Laboratory,Center for Medical Genetics,Hunan Key Laboratory of Animal Models for Human Diseases,Hunan Key Laboratory of Medical Genetics,Hunan International Scientific and Technological Cooperation Base of Animal Models for Human Diseases,School of Life Sciences,Central South University,Changsha 410078 Hunan,China [2]Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Wenzhou,Zhejiang 325000,China [3]Townsend Family Laboratories,Department of Psychiatry,The University of British Columbia,2255 Wesbrook Mall,Vancouver,BC V6T 1Z3,Canada [4]Institute of Aging,Key Laboratory of Alzheimer’s Disease of Zhejiang Province,School of Mental Health and Kangning Hospital,The Second Affiliated Hospital and Yuying Children’s Hospital,Wenzhou Medical University,Wenzhou,Zhejiang 325035,China [5]Advanced Innovation Center for Human Brain Protection,The National Clinical Research Center for Geriatric Disease,Xuanwu Hospital,Capital Medical University,Beijing 100053,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第7期3415-3426,共12页信号转导与靶向治疗（英文）

基　　金：This work was supported by funding from National Natural Science Foundation of China(NSFC),Grant/Award Number:81770780 and 31972913;Key Research and Development Programs from Hunan Province,Grant/Award Number:2021DK2001;Guangdong Key Project in‘Development of New Tools for Diagnosis and Treatment of Autism’,Grant/Award Number:2018B030335001;Strategic Priority Research Program of Central South University,Grant/Award Number:ZLXD2017004;The project has been funded in part with Independent Exploration and Innovation Project of Central South University,Grant/Award Number:2018zzts393.

摘　　要：As the most prevalent neurodevelopmental disorders in children,autism spectrum disorders(ASD)are characterized by deficits in language development,social interaction,and repetitive behaviors or inflexible interests.Contactin associated protein like 2(CNTNAP2),encoding a single transmembrane protein(CNTNAP2)with 1331 amino acid residues,is a widely validated ASD-susceptible gene.

关 键 词：BEHAVIORS CLEAVAGE RESIDUES 

分 类 号：R742.1[医药卫生—神经病学与精神病学]