DRUG-RESISTANCE

作品数：67被引量：213H指数：8
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相关领域：医药卫生更多>>
相关作者：刘福生王忠诚历俊华张亚卓张庆林更多>>
相关机构：天津医科大学北京市神经外科科研究所山东大学第二医院北京医科大学第一医院更多>>
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相关基金：国家自然科学基金北京市自然科学基金国家高技术研究发展计划安徽省自然科学基金更多>>
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BIRC3 induces the phosphoinositide 3-kinase-Akt pathway activation to promote trastuzumab resistance in human epidermal growth factor receptor 2-positive gastric cancer
《World Journal of Gastrointestinal Oncology》2024年第11期4436-4455,共20页Shu-Liang Li Pei-Yao Wang Yang-Pu Jia Zhao-Xiong Zhang Hao-Yu He Peng-Yu Chen Xin Liu Bang Liu Li Lu Wei-Hua Fu 
the Tianjin Municipal Education Commission Scientific Research Project,No.2018KJ055.
BACKGROUND Trastuzumab-targeted therapy is currently the standard of care for advanced human epidermal growth factor receptor 2(HER2)-positive gastric cancer.However,the emergence of resistance to trastuzumab poses si...
关键词：Gastric cancer Human epidermal growth factor receptor 2 TRASTUZUMAB DRUG-RESISTANCE BIRC3 
Aldo-keto reductases:Role in cancer development and theranostics
《Oncology Research》2024年第8期1287-1308,共22页SIDDAVARAM NAGINI PRATHAP REDDY KALLAMADI KRANTHI KIRAN KISHORE TANAGALA GEEREDDY BHANUPRAKASH REDDY 
SN and GBR are supported by grants from the Science and Engineering Research Board,Government of India(EMR/2016/001984);Indian Council of Medical Research.
Aldo-keto reductases(AKRs)are a superfamily of enzymes that play crucial roles in various cellular processes,including the metabolism of xenobiotics,steroids,and carbohydrates.A growing body of evidence has unveiled t...
关键词：Aldo-keto reductases(AKRs) Aldo-keto reductase(AKR)inhibitors CANCER DRUG-RESISTANCE Xenobiotics 
Emerging trends and future challenges of advanced 2D nanomaterials for combating bacterial resistance
《Bioactive Materials》2024年第8期225-257,共33页Saima Hameed Sumaira Sharif Muhammad Ovais Hai Xiong 
supported by the Science and Technology Innovation Commission of Shenzhen,China(20231121191245001 and JCYJ20210324095607021 to HX);the Special Project of Key Fields of Universities in Guangdong Province,China(2021ZDZX2047 to HX).
The number of multi-drug-resistant bacteria has increased over the last few decades,which has caused a detrimental impact on public health worldwide.In resolving antibiotic resistance development among different bacte...
关键词：2D nanomaterials Physicochemical properties Antibacterial mechanism Multi-drug-resistance Cellular nanotoxicity Nanotoxicity data availability 
HOXB8 contributed to oxaliplatin chemo-resistance in colon cancercells by activating STAT3
《BIOCELL》2023年第10期2245-2254,共10页LIANLI NI YUN YU HAN LIN WEISHAN ZHUGE LU TAO YIWEI SHEN RI CUI SHAOTANG LI 
supported by the Natural Science Foundation of Zhejiang Province(LZ22H160006);Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China(LHDMY22H160002);Wenzhou Municipal Science and Technology Bureau(Y20180085).
Background:Homeobox B8(HOXB8),a member of HOX family,plays a key role in the development of colorectal cancer(CRC).However,the function of HOXB8 in oxaliplatin(OXA)resistance in CRC is still unclear.This study investi...
关键词：HOXB8 DRUG-RESISTANCE Colorectal cancer STAT3 OXALIPLATIN 
Host defense peptide-mimicking peptide polymer-based antibacterial hydrogel enables efficient healing of MRSA-infected wounds被引量：2
《Science China Chemistry》2023年第6期1824-1833,共10页Zhongqian Qiao Wenjing Zhang Yueming Wu Weinan Jiang Ning Shao Jiayang Xie Guixue Xia Qimeng Chen Zhefeng Liu Jingcheng Zou Jiawei Gu Shifang Luan Haodong Lin Runhui Liu 
supported by the National Natural Science Foundation of China(22075078,52203162);the Program of Shanghai Academic/Technology Research Leader(20XD1421400);Shanghai Sailing Program(21YF1409100);China National Postdoctoral Program for Innovative Talents(BX20220108);the China Postdoctoral Science Foundation(2021M701198);the Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry(Changchun Institute of Applied Chemistry,Chinese Academy of Sciences);the Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism(2021Sci&Tech 03-28,Shanghai Municipal Education Commission)。
Wound infections are a compelling health issue caused by the invasion and proliferation of pathogens in wound sites.Antibioticloaded hydrogels are widely used to achieve anti-infectious wound healing.However,due to th...
关键词：peptide polymer wound healing MRSA DRUG-RESISTANCE host defense peptide 
Leveraging off higher plant phylogenetic insights for antiplasmodial drug discovery
《Natural Products and Bioprospecting》2023年第1期382-399,共18页Phanankosi Moyo Luke Invernizzi Sephora M.Mianda Wiehan Rudolph Warren A.Andayi Mingxun Wang Neil R.Crouch Vinesh J.Maharaj 
The antimalarial drug-resistance conundrum which threatens to reverse the great strides taken to curb the malaria scourge warrants an urgent need to find novel chemical scaffolds to serve as templates for the developm...
关键词：Natural products Plants PHYLOGENETICS MALARIA DRUG-RESISTANCE ‘Hot’plants 
Establishment and evaluation of an overlap extension polymerase chain reaction technique for rapid and efficient detection of drug-resistance in Mycobacterium tuberculosis被引量：2
《Infectious Diseases of Poverty》2022年第2期32-41,共10页Jungang Li Jing Ouyang Jing Yuan Tongxin Li Ming Luo Jing Wang Yaokai Chen 
supported by the Joint Medical Research Project of Chongqing Science&Technology Bureau and Chongqing Health Commission(2018MSXM013)。
Background:Rapid and accurate detection of drug resistance inMycobacterium tuberculosis is critical for effective control of tuberculosis(TB).Herein,we established a novel,low cost strategy having high accuracy and sp...
关键词：SOE-PCR Mycobacterium tuberculosis DRUG-RESISTANCE SEQUENCING 
Delineating the role of phytocompounds against anti-bacterial drug resistance–An update
《BIOCELL》2021年第6期1465-1477,共13页REKHA GAHTORI MOSLEH MOHAMMAD ABOMUGHAID NIDHI NEGI SARAVANAN KRISHNAN SUGAPRIYA DHANASEKARAN SOUMYA PANDIT KANU PRIYA DILLIP KUMAR BISHI RAM PRASAD PIYUSH KUMAR GUPTA 
the funding support from Science and Engineering Research Board(SERB),Department of Science and Technology,Govt.of India for the“Start-up Research Grant-2019”(SRG/2019/001995).
Antibacterial resistance developed by bacteria due to the unlimited use of antibiotics has posed a challenge for human civilization.This kind of problem is not limited to India only,but it is a global concern.Nowadays...
关键词：DRUG-RESISTANCE Phytocompounds ANTIBACTERIAL MECHANISMS Medicinal plants Natural products 
Theoretical Investigating Mechanisms of Drug-Resistance Generated by Mutation-Induced Changes in Influenza Viruses被引量：1
《Chinese Journal of Chemical Physics》2021年第6期785-796,I0003,I0061-I0067,共20页Song Luo Xiaoyu Zhao Yihui Wang Lili Duan 
supported by the National Natural Science Foundation of China(No.11774207)。
Influenza A(A/H_(x)N_(y))is a significant public health concern due to its high infectiousness and mortality.Neuraminidase,which interacts with sialic acid(SIA)in host cells,has become an essential target since its hi...
关键词：N9 Drug resistance Alanine-scanning-interaction-entropy method Binding free energy 
Ultrasmall Ga-ICG nanoparticles based gallium ion/photodynamic synergistic therapy to eradicate biofilms and against drug-resistant bacterial liver abscess被引量：5
《Bioactive Materials》2021年第11期3812-3823,共12页Tingting Xie Yuchen Qi Yangyang Li Feilu Zhang Wanlin Li Danni Zhong Zhe Tang Min Zhou 
the National Natural Science Foundation of China(No.81971667 and 81671748 and);the Key Research and Development Projection of Zhejiang Province(No.2020C03035).
Pyogenic liver abscess and keratitis are aggressive bacterial infections and the treatment has failed to eradicate bacteria in infectious sites completely owing to the currently severe drug resistance to existing anti...
关键词：DRUG-RESISTANCE Gallium-based compounds Indocyanine green Photodynamic therapy Liver infection 
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