Delineating the role of phytocompounds against anti-bacterial drug resistance–An update  

作　　者：REKHA GAHTORI MOSLEH MOHAMMAD ABOMUGHAID NIDHI NEGI SARAVANAN KRISHNAN SUGAPRIYA DHANASEKARAN SOUMYA PANDIT KANU PRIYA DILLIP KUMAR BISHI RAM PRASAD PIYUSH KUMAR GUPTA 

机构地区：[1]Department of Biotechnology,Sir J.C.Bose Technical Campus,Kumaun University,Nainital,India [2]Department of Medical Laboratory Sciences,University of Bisha,Bisha,Saudi Arabia [3]Department of Chemistry,Kumaun University,Nainital,India [4]Dhanvantari Nano Ayushadi Pvt.,Ltd.,Chennai,India [5]Department of Medical Laboratory Sciences(Pathology),College of Applied Medical Sciences,Prince Sattam Bin Abdulaziz University,Riyadh,Saudi Arabia [6]Department of Life Sciences,School of Basic Sciences and Research,Sharda University,Greater Noida,India [7]Department of Biotechnology,Rama Devi Women’s University,Bhubaneswar,India [8]Department of Botany,Mahatma Gandhi Central University,Motihari,India

出　　处：《BIOCELL》2021年第6期1465-1477,共13页生物细胞（英文）

基　　金：the funding support from Science and Engineering Research Board(SERB),Department of Science and Technology,Govt.of India for the“Start-up Research Grant-2019”(SRG/2019/001995).

摘　　要：Antibacterial resistance developed by bacteria due to the unlimited use of antibiotics has posed a challenge for human civilization.This kind of problem is not limited to India only,but it is a global concern.Nowadays,many treatments and medicines for bacterial diseases have been developed.However,they possess some drawbacks.Therefore,the alternative medicine has been used to target the drug resistant mechanisms and such medicines have less side effects which is becoming necessary.Natural products have traditionally or historically been of importance for the development of antibacterial agents and are also known to overcome bacterial drug resistance by directly targeting the drug resistance mechanisms in bacteria.In recent years,researchers have also focused on new drug discovery from plant-based research.They have looked on various phytocompounds as antibacterial agents.In the current review,we report various classes of secondary metabolites such as phenolic compounds,flavonoids,alkaloids,saponins,terpenes,quinones,and some essential oils that have been used as an antibacterial agent.In addition,we also discuss several mechanisms behind bacterial multi-drug resistance that are used during bacterial pathogenesis.

关 键 词：DRUG-RESISTANCE Phytocompounds ANTIBACTERIAL MECHANISMS Medicinal plants Natural products 

分 类 号：O62[理学—有机化学]