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通过鉴定关键靶标蛋白探究青蒿素抗疟机制: 《Engineering》2023年第12期86-97,共12页Peng Gao Jianyou Wang Jiayun Chen Liwei Gu Chen Wang Liting Xu Yin Kwan Wong Huimin Zhang Chengchao Xu Lingyun Dai Jigang Wang; supported by grants from the National Key Research and Development Program of China(2020YFA0908000 and 2022YFC2303600);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese-Medicine(ZYYCXTD-C-202002);the National Natural Science Foundation of China(82141001,82274182,82074098,82003814,and 82173914);the China Academy of Chinese Medical Sciences(CACMS)Innovation Fund(CI2021A05104 and CI2021A05101);the Distinguished Expert Project of Sichuan Province Tianfu Scholar(CW202002);the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(CI2021B014);the China Postdoctoral Science Foundation(2022M721541);the Establishment of Sino-Austria‘‘Belt and Road”Joint Laboratory on Traditional Chinese Medicine for Severe Infectious Diseases and Joint Research(2020YFE0205100);the Excellent Scientific and Technological Innovation Training Program of Shenzhen(RCYX20210706092040048);the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ14-YQ-051,ZZ14-YQ-052,ZZ14-FL-002,ZZ14-YQ-050,ZZ14-ND-010,and ZZ15-ND-10);the Introduce Innovative Team Projects of Jinan(202228029)。; The widespread use of artemisinin(ART)and its derivatives has significantly reduced the global burden of malaria;however,malaria still poses a serious threat to global health.Although significant progress has been ach...; 关键词：ARTEMISININ ANTIMALARIA Target identification MS-CETSA TRANSCRIPTOMICS

Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA被引量：1: 《Military Medical Research》2023年第1期64-77,共14页Peng Gao Yan-Qing Liu Wei Xiao Fei Xia Jia-Yun Chen Li-Wei Gu Fan Yang Liu-Hai Zheng Jun-Zhe Zhang Qian Zhang Zhi-Jie Li Yu-Qing Meng Yong-Ping Zhu Huan Tang Qiao-Li Shi Qiu-Yan Guo Ying Zhang Cheng-Chao Xu Ling-Yun Dai Ji-Gang Wang; suppor ted by the National Key Research and Development Program of China(2020YFA0908000);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-C-202002);the National Natural Science Foundation of China(82074098,82003814);the CACMS Innovation Fund(CI2021A05101);the Fundamental Research Funds for the Central public welfare research institutes(ZZ14-YQ-050,ZZ14-YQ-051,ZZ14-ND-010,ZZ15-ND-10 and ZZ14-FL-002)。; Background: Malaria is a devastating infectious disease that disproportionally threatens hundreds of millions of people in developing countries. In the history of anti-malaria campaign, chloroquine(CQ) has played an i...; 关键词：CHLOROQUINE ANTIMALARIA Activity-based protein profiling(ABPP) Cellular thermal shift assay(CETSA) Quantitative proteomics

Development of peptidomimetic hydroxamates as PfA-M1 and PfA-M17 dual inhibitors: Biological evaluation and structural characterization by cocrystallization: 《Chinese Chemical Letters》2022年第5期2550-2554,共5页Anil Kumar Marapaka Priyanka Sankoju Guozhen Zhang Yongzheng Ding Chunhua Ma Vijaykumar Pillalamarri Renu Sudhakar Bharati Reddi Puran Singh Sijwali Yingjie Zhang Anthony Addlagatta; supported by University Grants Commission (UGC), New Delhi, India and Bharati Reddi by Department of Science and Technology, New Delhi, India for their research fellowships;CSIR-IICT manuscript number is IICT/Pubs./2018/299;Anthony Addlagatta thanks Science and Engineering Research Board (SERB), New Delhi, India for research grants (Nos. EMR/2015/000461 and CRG/2019/006013);Natural Science Foundation of Shandong Province (No. ZR2018QH007, China);Key Research and Development Program of Shandong Province (No. 2017CXGC1401, China);Young Scholars Program of Shandong University (No. YSPSDU, 2016WLJH33, China) for research fellowships;Renu Sudhakar is the recipient of the fellowship from the Department of Biotechnology (India);Puran Singh Sijwali lab is supported with funds from the Department of Biotechnology, India (Nos. SR/SO/BB/-0124/2012 and BT/COE/34/SP15138/2015);the Council of Scientific & Industrial Research, India; Plasmodium parasites causing malaria have developed resistance to most of the antimalarials in use,in-cluding the artemisinin-based combinations,which are the last line of defense against malaria.This ne-cessitates th...; 关键词：AMINOPEPTIDASE Dual inhibitor ANTIMALARIA PEPTIDOMIMETIC Plasmodium falciparum

Evidence for Neurotoxicity from Quinoline Antimalaria Drugs: Four Personal Accounts: 《Open Journal of Animal Sciences》2017年第1期45-55,共11页Ashley M. Croft Anthony R. Mawson; Background: The adverse effects of mefloquine and other quinoline antimalaria drugs can be severe and long-lasting. We believe that the trigger for these effects may be drug-induced hepatocellular damage that causes, ...; 关键词：AFGHANISTAN Bales Lariam MALARIA MEFLOQUINE Pibloktoq

A combination of the leaves and tuber of Icacina senegalensis A.Juss(Icacinaceae)improves the antimalarial activity of the plant in mice: 《Journal of Coastal Life Medicine》2015年第10期821-825,共5页Esien David-Oku Juliet Ifeoma Obiajunwa-Otteh; Objective:To investigate the possibility of increased antimalarial activity of Icacina senegalensis A.Juss(Icacinaceae)upon a combination of its leaves and tubers against Plasmodium berghei malaria in mice.Methods:Chl...; 关键词：Icacina senegalensis tuber ANTIMALARIA MICE Plasmodium berghei Chemosuppression CURATIVE

A review of age-old antimalarial drug to combat malaria:efficacy upgradation by nanotechnology based drug delivery: 《Asian Pacific Journal of Tropical Medicine》2014年第9期673-679,共7页Satyajit Tripathy Somenath Roy; Malaria is uncontrolled burden in the world till now.Despite of different efforts to develop antimalarial drug for decades,any anti-malarial drug can able to eradicate completely till now.Many anti-malarial substances...; 关键词：NANOTECHNOLOGY Age-old DRUG DRUG EFFICACY ANTIMALARIA NANOMEDICINE

Antimalarial potential of kolaviron,a biflavonoid from Garcinia kola seeds,against Plasmodium berghei infection in Swiss albino mice被引量：3: 《Asian Pacific Journal of Tropical Medicine》2014年第2期97-104,共8页Adaramoyc Oluwatosin Akinpelu Tolulope Kosoko Ayokulchin Okoric Patricia Kehinde Aderemi Falade Catherine Ademowo Olusegun; Objective:To investigate the antimalarial potential of kolaviron(KV),a biflavonoid fraction from Garcinia kola seeds,against Plasmodium berghei(P.berghei)infection in Swiss albino mice.Methods:The study consists of se...; 关键词：ANTIMALARIA Antioxidant BIFLAVONOID KOLAVIRON PLASMODIUM BERGHEI

Oral Amodiaquine, Artesunate and Artesunate Amodiaquine Combination Affects Open Field Behaviors and Spatial Memory in Healthy Swiss Mice: 《Journal of Behavioral and Brain Science》2013年第8期569-575,共7页Adejoke Yetunde Onaolapo Olakunle James Onaolapo Emmanuel O. Awe Samuel Oloyede Ayomide Joel; Effects of amodiaquine, artesunate and artesunate amodiaquine combination on open field novelty-induced behaviors and spatial memory in healthy mice were studied. Forty mice were used in the open field and fifty each ...; 关键词：NEUROBEHAVIOR ARTESUNATE AMODIAQUINE ANTIMALARIA Novelty-Induced Behaviors Cognition

Chemical Compositions of <i>Lonchocarpus cyanescens</i>Benth., (Fabaceae)—Case Study of Its Volatile Oils, and Two Triterpenoids: 《American Journal of Plant Sciences》2013年第8期1653-1659,共7页Dorcas Olufunke Moronkola Ibrahim Adebayo Oladosu; Leaf and stem essential oils of Lonchocarpus cyanescens Benth., (Fabaceae) were obtained by hydro-distillation, using all-glass apparatus adapted to British Pharmacopeia specifications with yields of 0.03% and 0.17% r...; 关键词：Lonchocarpus cyanescens FABACEAE ANTIMALARIA PHYTOCHEMISTRY Essential Oils GC GC-MS HPLC IR 1H and 13C-NMR

Effect of artemether on hematological parameters of healthy and uninfected adult Wistar rats被引量：1: 《Asian Pacific Journal of Tropical Biomedicine》2012年第6期493-495,共3页Osonuga IO Osonuga OA Osonuga A Onadeko AA Osonuga AA; Objective:To evaluate the effect of short term artemether administration on some blood parameters in adult male Wistar rats.Methods:Sixty five albino rats with body weight of 190-220 g were used for the four-phased st...; 关键词：ARTEMETHER ANEMIA ANTIMALARIA HEMATOLOGY HEMATOLOGICAL profile Malaria ANEMIC tendency

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