ARTEMISININ

作品数：182被引量：792H指数：15
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相关领域：医药卫生生物学更多>>
相关作者：罗大力陈海军高瑜叶和春李国凤更多>>
相关机构：哈尔滨医科大学福州大学中国科学院植物研究所南京大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划World Health Organization中国博士后科学基金更多>>
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Artemisinin inhibits neuronal ferroptosis in Alzheimer’s disease models by targeting KEAP1
《Acta Pharmacologica Sinica》2025年第2期326-337,共12页Peng-xi Deng Marta Silva Na Yang Qing Wang Xin Meng Ke-qiang Ye Hong-chang Gao Wen-hua Zheng 
supported by National Natural Science Foundation of China(32070969 and 22274115);the Science and Technology Development Fund,Macao SAR(0104/2022/A2 and 0038/2020/AMJ);Guangdong,Hong Kong and Macao Joint Key Laboratory for New Drug Screening(EF2023-00054-FHS,GDSTC);the Guangdong Provincial Funding Committee for Basic and Applied Fundamental Research(2022-Natural Science Foundation,EF019/FHS-ZWH/2022,GDSTC);University of Macao(MYRG-CRG2024-00019-FHS,MYRG-GRG2023-00118-FHS-UMDF and MYRG2022-00154-FHS).
Ferroptosis,a form of cell death characterized by lipid peroxidation,is involved in neurodegenerative diseases such as Alzheimer´s disease(AD).Recent studies have shown that a first-line antimalarial drug artemisinin...
关键词：Alzheimer’s disease ARTEMISININ ferroptosis KEAP1 Nrf2 HIPPOCAMPUS 
The AaBBX21–AaHY5 module mediates light-regulated artemisinin biosynthesis in Artemisia annua L.
《Journal of Integrative Plant Biology》2024年第8期1735-1751,共17页Weizhi He Hang Liu Zhangkuanyu Wu Qing Miao Xinyi Hu Xin Yan Hangyu Wen Yaojie Zhang Xueqing Fu Li Ren Kexuan Tang Ling Li 
supported by the National Natural Science Foundation of China (32070329, 31770327);Shanghai Natural Science Foundation (16ZR1418000);the National Key R&D Program of China (2018Y FA0900600)。
The sesquiterpene lactone artemisinin is an important anti-malarial component produced by the glandular secretory trichomes of sweet wormwood(Artemisia annua L.).Light was previously shown to promote artemisinin produ...
关键词：AaBBX21 AaHY5 AaCOP1 Artemisia annua L. artemisinin biosynthesis LIGHT 
Reversal of tamoxifen resistance by artemisinin in ER+breast cancer:bioinformatics analysis and experimental validation被引量：1
《Oncology Research》2024年第6期1093-1107,共15页ZHILI ZHUO DONGNI ZHANG WENPING LU XIAOQING WU YONGJIA CUI WEIXUAN ZHANG MENGFAN ZHANG 
supported by the National Natural Science Foundation of China(81973839);High Level Chinese Medical Hospital Promotion Project-Special Project on Formulation R&D and New Drug Translation for Medical Institutions(HLCMHPP2023037);Upgrading the Development and Promotion of about 30 Integrated Chinese and Western Medicine Diagnosis and Treatment Programs(Guidelines for the Diagnosis and Treatment of Breast Cancer with the Combination of Traditional Chinese Medicine and Western Medicine)(ZYZB-2022-798).
Breast cancer is the leading cause of cancer-related deaths in women worldwide,with Hormone Receptor(HR)+being the predominant subtype.Tamoxifen(TAM)serves as the primary treatment for HR+breast cancer.However,drug re...
关键词：ARTEMISININ Tamoxifen resistance Breast cancer 
Reversing artemisinin resistance by leveraging thermo-responsive nanoplatform to downregulating GSH
《Chinese Chemical Letters》2024年第6期392-397,共6页Yong-Dan Zhao Yidan Wang Rongrong Wang Lina Chen Hengtong Zuo Xi Wang Jihong Qiang Geng Wang Qingxia Li Canqi Ping Shuqiu Zhang Hao Wang 
supported by the National Natural Science Foundation of China(Nos.81803470 and 82173767)。
Artemisinin(ART)resistance has been an emerging clinical problem,severely compromising antimalarial efficacy and threatening the global malaria elimination campaign.Albeit intensive studies about the molecular mechani...
关键词：NANOMEDICINES Drug delivery Artemisinins resistance Malaria GLUTATHIONE 
TrichomeLess Regulator 3 is required for trichome initial and cuticle biosynthesis in Artemisia annua
《Molecular Horticulture》2024年第1期449-467,共19页Boran Dong Zihan Xu Xingxing Wang JinXing Li Ying Xiao Doudou Huang Zongyou Lv Wansheng Chen 
funded by National Natural Science Foundation of China(32070332);Shanghai local Science and Technology Development Fund Program guided by the Central Government(YDZX20203100002948);National Key R&D Program of China(2022YFC3501700,2023YFC3504800).
Artemisinin is primarily synthesized and stored in the subepidermal space of the glandular trichomes of Artemi-sia annua.The augmentation of trichome density has been demonstrated to enhance artemisinin yield.However,...
关键词：Artemisia annua ARTEMISININ Glandular trichomes Trichome morphology Cuticle Negative regulation 
Graphene enhances artemisinin production in the traditional medicinal plant Artemisia annua via dynamic physiological processes and miRNA regulation被引量：1
《Plant Communications》2024年第3期31-46,共16页Junfeng Cao Zhiwen Chen Luyao Wang Ning Yan Jialing Lin Lipan Hou Yongyan Zhao Chaochen Huang Tingting Wen Chenyi Li Saeed ur Rahman Zehui Liu Jun Qiao Jianguo Zhao Jie Wang Yannan Shi Wei Qin Tong Si Yuliang Wang Kexuan Tang 
supported by the National Natural Science Foundation of China (82274047 and 52071192);the National Key R&D Program of China (2018YFA0900600);the Engineering Research Center of Coal-Based Ecological Carbon Sequestration Technology of the Ministry of Education (MJST2023-3);the China Postdoctoral Science Foundation (2023M732232);SJTU Trans-med Awards Research (20190104);supported in part by the Bill&Melinda Gates Foundation (OPP1199872 and INV-027291).
We investigated the effects of graphene on the model herb Artemisia annua,which is renowned for produc-ing artemisinin,a widely used pharmacological compound.Seedling growth and biomass were promoted when A.annua was ...
关键词：Artemisia annua ARTEMISININ glandular secreting trichomes GSTs MIRNA GRAPHENE 
通过鉴定关键靶标蛋白探究青蒿素抗疟机制
《Engineering》2023年第12期86-97,共12页Peng Gao Jianyou Wang Jiayun Chen Liwei Gu Chen Wang Liting Xu Yin Kwan Wong Huimin Zhang Chengchao Xu Lingyun Dai Jigang Wang 
supported by grants from the National Key Research and Development Program of China(2020YFA0908000 and 2022YFC2303600);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese-Medicine(ZYYCXTD-C-202002);the National Natural Science Foundation of China(82141001,82274182,82074098,82003814,and 82173914);the China Academy of Chinese Medical Sciences(CACMS)Innovation Fund(CI2021A05104 and CI2021A05101);the Distinguished Expert Project of Sichuan Province Tianfu Scholar(CW202002);the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(CI2021B014);the China Postdoctoral Science Foundation(2022M721541);the Establishment of Sino-Austria‘‘Belt and Road”Joint Laboratory on Traditional Chinese Medicine for Severe Infectious Diseases and Joint Research(2020YFE0205100);the Excellent Scientific and Technological Innovation Training Program of Shenzhen(RCYX20210706092040048);the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ14-YQ-051,ZZ14-YQ-052,ZZ14-FL-002,ZZ14-YQ-050,ZZ14-ND-010,and ZZ15-ND-10);the Introduce Innovative Team Projects of Jinan(202228029)。
The widespread use of artemisinin(ART)and its derivatives has significantly reduced the global burden of malaria;however,malaria still poses a serious threat to global health.Although significant progress has been ach...
关键词：ARTEMISININ ANTIMALARIA Target identification MS-CETSA TRANSCRIPTOMICS 
Increased artemisinin production by promoting glandular secretory trichome formation and reconstructing the artemisinin biosynthetic pathway in Artemisia annua被引量：1
《Horticulture Research》2023年第5期275-277,共3页Yongpeng Li Wei Qin Hang Liu Tiantian Chen Xin Yan Weizhi He Bowen Peng Jin Shao Xueqing Fu Ling Li Xiaolong Hao Guoyin Kai Kexuan Tang 
This work was supported by National Key R&D Program of China(2018YFA0900600);the Bill&Melinda Gates Foundation(OPP1199872 and INV-027291);the China Postdoctoral Science Foundation(2022M722851);the National Natural Science Foundation of China(82274047,31770327,32070329,82003889);SJTU Trans-med Awards Research(20190104);SJTU Global Strategic Partnership Fund(2020 SJTU-CORNELL);Zhejiang Provincial Natural Science Foundation of China(LQ21H280004);National Young Qihuang Scholars Training Program;the National‘Ten-thousand Talents Program’for Leading Talents of Science and Technology Innovation in China.
Dear Editor,Artemisinin,which has potent antimalarial properties,is a sesquiterpene endoperoxide originally isolated from the traditional Chinese medicinal plant Artemisia annua.However,the artemisinin content in wild...
关键词：PRICE annua originally 
Promoter variations in DBR2-like affect artemisinin production in different chemotypes of Artemisia annua
《Horticulture Research》2023年第9期220-232,共13页Xingwen Wang Lan Wu Li Xiang Ranran Gao Qinggang Yin Mengyue Wang Zhaoyu Liu Liang Leng Yanyan Su Huihua Wan Tingyu Ma Shilin Chen Yuhua Shi 
supported by the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ13-YQ-101,ZZ16-ND-10-09,ZZ16-ND-10-28);the CACMS Innovation Fund(CI2021A04107),the National Natural Science Foundation of China(U1812403-1);the National Key Research and Development Project(2019YFE0108700,China);the Fundamental Research Funds for the Central Universities(3332022051).
Artemisia annua is the only known plant source of the potent antimalarial artemisinin,which occurs as the low-and high-artemisinin producing(LAP and HAP)chemotypes.Nevertheless,the different mechanisms of artemisinin ...
关键词：thereby INSIGHT HOMOLOGOUS 
Antiviral effects of artemisinin and its derivatives
《Chinese Medical Journal》2023年第24期2993-2995,共3页Hao Liu Zhen Li Yang Zhang Lin Jia Miaotian Cai Rui Wang Caiping Guo 
supported by grants from the National Natural Science Foundation of China(Nos.82072271 and 82072294);the Beijing Natural Science Foundation(No.7222091);the Peak Talent Program of Beijing Hospital Authority(No.DFL20191701);the Beijing Hospitals Authority Innovation Studio of Young Staff Funding Support(No.202137);the High-level Public Health Technical Personnel Construction Project,and the Beijing Key Laboratory for HIV/AIDS Research(No.BZ0089)
To the Editor:Artemisinin is a sesquiterpene lactone compound with a peroxide bridge structure,which is extracted and isolated from the medicinal plant,Artemisia annua L.Existing studies have revealed a broad spectrum...
关键词：DERIVATIVES SPECTRUM PREVENTION 
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