云南高校图书馆联盟文献共享服务平台- SURAMIN

SURAMIN: 作品数：16被引量：26H指数：3; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：杨剑敏王颀李文萍李杰恩赵延东更多>>; 相关机构：广州医学院贵州医科大学复旦大学南方医科大学更多>>; 相关期刊：《中华肾脏病杂志》《Acta Pharmacologica Sinica》《Infectious Diseases of Poverty》《Journal of Chinese Pharmaceutical Sciences》更多>>; 相关基金：国家自然科学基金广东省自然科学基金广东省医学科学技术研究基金河南省教育厅科学技术研究重点项目更多>>

The bumpy road of purinergic inhibitors to clinical application in immune-mediated diseases: 《Neural Regeneration Research》2024年第6期1206-1211,共6页Matthias T.Wyss Christine Heuer Marina Herwerth; supported by the UZH Postdoc grant(to MH);the Foundation for Research in Science at the University of Zurich(to MTW)。; Purinergic signaling plays important roles throughout the body in the regulation of organ functions during and following the disruption of homeostasis.This is also reflected by the widespread expression of two familie...; 关键词：autoimmune diseases neurological disorders purinergic system P2 receptor inhibitors SURAMIN

Suramin对环孢素A诱导的大鼠肾毒性的影响被引量：1: 《临床内科杂志》2019年第12期842-845,共4页叶薇陈凯鲍晓荣; 上海市金山区卫生和计划生育委员会科研课题面上项目(JSKJ-KTMS-2016-06)。; 目的探讨Suramin对环孢素A(CsA)所致肾毒性的拮抗作用及其相关机制。方法将40只雄性SD大鼠随机分为对照组、CsA组、CsA+小剂量Suramin组和CsA+大剂量Suramin组,每组10只。分别给药5周后检测4组大鼠24h尿蛋白、尿α1-微球蛋白(MG)、β2-M...; 关键词：环孢素A SURAMIN 肾毒性

白藜芦醇通过激活SIRT1在阿尔茨海默病发病机制中的神经保护作用被引量：4: 《中国药理学与毒理学杂志》2019年第6期423-423,共1页曹坤向洁董阳婷徐毅龙艳李毅官志忠; 目的沉默信息调节因子(SIRT)是一组依赖于烟酰胺腺嘌呤二核苷酸(NAD+)激活的具有去乙酰化作用的蛋白。本研究通过观察慢β-淀粉样肽前体蛋白(APP)高表达转基因小鼠及经Aβ处理的体外培养神经细胞中SIRT1的表达,探讨其在AD中枢神经损伤...; 关键词：沉默信息调节因子白藜芦醇 AΒ蛋白 SURAMIN Α-分泌酶 Β-分泌酶

Trypanosoma brucei rhodesiense infection in a Chinese traveler returning from the Serengeti National Park in Tanzania被引量：6: 《Infectious Diseases of Poverty》2018年第1期486-491,共6页Qin Liu Xiao-Ling Chen Mu-Xin Chen Han-Guo Xie Qing Liu Zhu-Yun Chen Yao-Ying Lin Hua Zheng Jia-Xu Chen Yi Zhang Xiao-Nong Zhou; This work was supported by the National Key Research and Development Program of China(Grant Nos.2016YFC1202000,2016YFC1202002);by the International Development Research Center(IDRC),Canada(grant No.108100–001).; Background:Human African trypanosomiasis(HAT)is one of the most complex parasitic diseases known to humankind.It usually occurs in endemic areas in Africa,but is occasionally detected in returning travelers and migran...; 关键词：Trypanosoma brucei rhodesiense Human African trypanosomiasis Imported infection China Treatment SURAMIN Tanzania

苏拉明抑制尿酸诱导的肾间质成纤维细胞增殖和活化被引量：1: 《中华肾脏病杂志》2016年第7期534-536,共3页王亚琨白寿军朱迎春刘娟姬婷婷李肖瑛; 上海市自然基金（13ZR1407200）;上海市卫计委基金（201224231）; 高尿酸血症发病率逐渐增高，血尿酸（UA）≥6.5 mg/dl是慢性肾脏病（CKD）进展的独立危险因子。苏拉明（suramin，SUR）属于多磺酸萘醌盐类，早期用于治疗非洲锥虫病和盘丝尾虫病，近年来发现SUR可用于肿瘤治疗及肾间质纤维化（RIF）的...; 关键词：成纤维细胞增殖肾间质纤维化高尿酸血症苏拉明肾间质成纤维细胞 SURAMIN 活化独立危险因子

An Odyssey in antiviral drug development—50 years at the Rega Institute:1964–2014被引量：3: 《Acta Pharmaceutica Sinica B》2015年第6期520-543,共24页Erik De Clercq; I.How it started I entered the Rega Institute for Medical Research in August 1964,as a medical student,to start working under the guidance of Prof.Piet De Somer,then professor of microbiology at the Leuven School of M...; 关键词：Erik De Clercq Antiviral drug Poly(I) poly(C) Polyacrylic acid Interferon Reverse transcriptase SURAMIN VALACICLOVIR Brivudin STAVUDINE Tenofovir disoproxil fumarate(TDF) Truvada~ Atripla~ Complera~/Eviplera~ Stribild~ FV-100 Mozobil~ Tenofovir alafenamide(TAF) Holy's legacy Sofosbuvir

Development of a C3c-based ELISA method for the determination of anti-complementary potency of Bupleurum polysaccharides被引量：1: 《Acta Pharmaceutica Sinica B》2015年第4期316-322,共7页Mulu Wu Hong Li Yunyi Zhang Daofeng Chen; supported by grants from the National Natural Science Foundation of China (Nos. 81274165, 81330089 and 30925042);the State Key Program for Innovative Drugs from the Ministry of Science and Technology of the people’s Republic of China (No. 2012ZX09301001-003);the Science and Technology Commission of Shanghai Municipality (Nos. 12JC1400800 and 10XD1405900);Fudan's Undergraduate Research Opportunities Program (Xiyuan, No. 102305); Traditionally, determination of inhibitory potency of complement inhibitors is performed by the hemolytic assay. However, this assay is not applicable to the lectin pathway, thus impeding the understanding of compleme...; 关键词：ELISA Complement C3c SURAMIN Bupleurum smithti var. parvifolium Bupleurum chinense POLYSACCHARIDES

β淀粉样蛋白对三磷腺苷所致大鼠海马神经元损伤的影响被引量：2: 《新乡医学院学报》2014年第9期691-694,共4页李晓娟白瑞樱郭直岳李成长王晓芳王亚莉; 河南省教育厅科学技术研究重点项目(编号:13A310855);新乡医学院科研培育基金资助(编号:2013QN101); 目的探讨β淀粉样蛋白(Aβ)对三磷腺苷(ATP)引起的大鼠海马神经元损伤的影响及其相互作用。方法孕18 d大鼠取其胎鼠迅速断头取出海马神经组织进行原代培养,实验分为正常对照组、ATP组、Aβ组、ATP+Aβ组、Suramin组。使用台盼蓝计数检...; 关键词：三磷腺苷 Β淀粉样蛋白 SURAMIN 受体海马神经元

Suramin对实验性大鼠乳腺癌化学预防作用的研究被引量：3: 《中华肿瘤防治杂志》2011年第7期494-497,共4页杨剑敏王颀李文萍; 广东自然科学基金博士启动基金05300299;广东省医学科研课题(B2004009); 目的:探讨血管生成抑制剂Suramin对实验性大鼠乳腺癌的化学预防作用。方法:40只SD雌性大鼠,随机分为4组:A组12只,腹腔注射甲基亚硝脲(MNU);B组8只,腹腔注射MNU,在导管内癌(DCIS)生成高峰前皮下注射Suramin;C组8只,腹腔注射MNU,在DCIS生...; 关键词：乳腺肿瘤甲基亚硝脲大鼠化学预防

Effects of suramin on proliferation and apoptosis of hepatic stellate cells of hepatic fibrosis rats: 《Journal of Chinese Pharmaceutical Sciences》2011年第4期415-420,共6页陈新修贺明姜慧卿; The aim of the study was to investigate the role of suramin in the proliferation and apoptosis of activated hepatic stellate cells（HSCs）.HSCs were cultured in medium with different doses of suramin.The cell prolifer...; 关键词：SURAMIN Hepatic stellate cells PROLIFERATION APOPTOSIS Hepatic fibrosis

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

SURAMIN

检索结果分析

下载全文

高级检索检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

SURAMIN

检索结果分析

下载全文

用户登录

高级检索检索式检索