BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)is the most common chronic liver disease worldwide.Its prevalence is closely linked to the dramatic rise in obesity and non-communicable diseas...
supported by Fondazione Cariplo(grant number 2020-0900).
In insects,the cell-mediated immune response involves an active role of hemo-cytes in phagocytosis,nodulation,and encapsulation.Although these processes have been well documented in multiple species belonging to diffe...
Scar tissue usually generates severe discomfort in the short and long term. Common symptoms include anesthetics sequelae, pruritus, joint malfunction, new wounds on the scar surface, and pain. There are several treatm...
supported by grants from the National Natural Science Foundation of China(81790624[to D.W.W.],81900342[to L.P.]and 81790621[to Y.Z.]).
Epoxyeicosatrienoic acids(EETs)have pleiotropic endogenous cardiovascular protective effects and can be hydrolyzed to the corresponding dihydroxyeicosatrienoic acids by soluble epoxide hydrolase(sEH).Heart failure wit...
supported by1R01EY030054(MA),NIH-1R01EY029751(AT);supported in part by National Center for Research Resources,National Institutes of Health Grant S10RR027926.
Hyperhomocysteinemia(HHcy)contributes to the incidence of many cardiovascular diseases(CVD).Our group have previously established crucial roles of eicosanoids and homocysteine in the incidence of vascular injury in di...
National Medical Research Council(NMRC/OFIRG/0042/2017);National Research Foundation(NRF2019-NRF-ISF003-3221);Ministry of Education(MOE-T2EP30220-0029),Singapore to S.-C.L.
Lipids,defined by low solubility in water and high solubility in nonpolar solvents,can be classified into fatty acids,glycerolipids,glycerophospholipids,sphingolipids,and sterols.Lipids not only regulate integrity and...
This work was supported by the National Natural Science Foundation of China(Nos.82073975,81673563,81102762,and 2018YFC1706200);the Open Project Program of Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization/Jiangsu Key Laboratory for High Technology Research ofTCM Formulae(Nos.ZDXM-1-14,FJGJS-2015-15);the Fund of Quality Standardization of Liu-Shen-Wan(Nos.BA2016104,ZYBZH-C-JS-30),and Jiangsu Qing Lan Project for Young academic leaders.
Chansu has demonstrated adverse reactions in clinical settings,which is associated with its toxicity and limits its clinical applications.But there are methodological limitations for drug safety evaluation.In the curr...
supported by grants from the INSERM(Peyruchaud O),the UniversitéClaude Bernard Lyon 1(Peyruchaud O);and the ANR grant BoneTAX(Grant No.ANR-20-CE14-0036-01)(Peyruchaud O);Saier L was the recipient of a fellowship from the French Ministère de l’Enseignement Supérieur et de la Recherche.Niazi H was supported by Higher Education Commission of Pakistan.This work was funded in part by the Else Kröner-Fresenius-Stiftung(Levkau B).
Bioactive lipids constitute a large family of molecules considered as inflammatory mediators.Among them,lysophosphatidic acid(LPA),sphingosine 1-phosphate(S1P),and eicosanoids(prostanoids such as PGE2 and leukotrienes...
The National Center for Advancing Translational Sciences of the National Institutes of Health under Award Number UL1TR002378 and KL2TR002381.The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Aspirin-exacerbated respiratory disease(AERD)is characterized by the triad of chronic rhinosinusitis with nasal polyposis,adult-onset asthma and non-IgE mediated reactions to aspirin and other cyclooxygenase-1(COX-1)i...
This research is supported by a new faculty start-up from the University of Massachusetts Amherst,USDA NIFA2016-67017-24423,USDA NIFA 2019-67017-29248,USDA/HatchMAS00492,and NIH/NCIR03 CA218520(to G.Z.).
Human consumption of linoleic acid(LA,18:2ω-6,abundant in vegetable oils)is very high.Animal experiments showed that excessive LA intake increased azoxymethane-induced colon tumorigenesis,however,the impact of excess...