HOMOCYSTEINE

作品数：267被引量：1291H指数：18
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相关领域：医药卫生更多>>
相关作者：郭航远吴琳蒋鹏李开军张力华更多>>
相关机构：中国医科大学山西医科大学浙江大学医学院附属第二医院河北医科大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金国家教育部博士点基金更多>>
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Homocysteine Levels and Determinants among Chinese Women at Mid-pregnancy, Late Pregnancy, and Postpartum
《Biomedical and Environmental Sciences》2025年第4期459-468,共10页Zhenyu Guo Hongtian Li Yirui Ma Ying Meng Yubo Zhou Jianmeng Liu 
Objective Data on homocysteine(Hcy) status and its determinants are limited among women during pregnancy and postpartum. This cross-sectional study aimed to investigate Hcy levels during pregnancy and postpartum, and ...
关键词：HOMOCYSTEINE HYPERHOMOCYSTEINEMIA Pregnancy and postpartum Determinants 
Serum homocysteine showed potential association with cognition and abnormal gut microbiome in major depressive disorder
《World Journal of Psychiatry》2025年第3期234-248,共15页Chen-Chen Xu Wen-Xuan Zhao Yu Sheng Ya-Jun Yun Ting Ma Ning Fan Jia-Qi Song Jun Wang Qi Zhang 
Supported by the Wuxi Municipal Health Commission Youth Fund Project,No.Q202268;Wuxi Scientific and technological breakthrough of“Light of the Taihu Lake”(Basic Research),No.K20221039;Jiangsu Shuangchuang Doctoral Program,No.JSSCBS20221991;Beijing Municipal Administration of Hospital Incubating Program,No.PX2023070 and No.PX2024072;Capital’s Funds for Health Improvement and Research,No.SF2024-4-2134;Beijing Hospitals Authority Youth Program,No.QML20232003;the Top Talent Support Program for young and middle-aged people of Wuxi Health Committee,No.HB2023089.
BACKGROUND Cognitive impairment is one of the common clinical manifestations of depression,causing negative distress to patients.Elevated homocysteine(Hcy)concentrations and gut microbiome dysfunction may be observed ...
关键词：HOMOCYSTEINE MICROBIOME Intestinal flora Gut microbiota Gut-brain axis Major depressive disorder Cognitive function Cognitive impairment 
Viscosity-responsive signal amplification dual-modal probe triggered by cysteine/homocysteine for monitoring diabetic liver damages and repair processes
《Chinese Chemical Letters》2025年第3期328-334,共7页Sixin Ai Wenxiu Li Huayong Zhu Yang Wan Weiying Lin 
financially supported by the National Natural Science Foundation of China(Nos.21877048,22077048,and 22277014);Guangxi Natural Science Foundation(Nos.2021GXNSFDA075003,AD21220061);the Startup Fund of Guangxi University(No.A3040051003).
Diabetic liver injury is a widespread complication of diabetes and carries a high risk to liver function.Therefore,early diagnosis of diabetic liver injury is of great significance for providing quality of life for di...
关键词：Cysteine/homocysteine Viscosity responsive Near-infrared fluorescence Photoacoustic imaging Fluorescence imaging 
Correction: Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis
《Signal Transduction and Targeted Therapy》2025年第1期471-472,共2页Han Yan Wenjun Liu Rui Xiang Xin Li Song Hou Luzheng Xu Lin Wang Dong Zhao Xingkai Liu Guoqing Wang Yujing Chi Jichun Yang 
Correction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/s41392-024-01914-0,published online 08 August 2024 In the process of collating the raw data,the authors noticed one inadvertent mistake in...
关键词：HEPATIC CORRECTION repeatedly 
Targeted delivery of rosuvastatin enhances treatment of hyperhomocysteinemia-induced atherosclerosis using macrophage membrane-coated nanoparticles
《Journal of Pharmaceutical Analysis》2024年第9期1301-1319,共19页Dayue Liu Anning Yang Yulin Li Zhenxian Li Peidong You Hongwen Zhang Shangkun Quan Yue Sun Yaling Zeng Shengchao Ma Jiantuan Xiong Yinju Hao Guizhong Li Bin Liu Huiping Zhang Yideng Jiang 
supported by the National Natural Science Foundation of China(Grant Nos.:U21A20343,82160088,81870225,81870332,81700404,82271626,and 82260088);the Natural Science Foundation of Ningxia Autonomous Region,China(Grant Nos.:2020AAC02021,2020AAC02038,and 2022AAC05025);the Key Research and Development Projects in Ningxia Autonomous Region,China(Grant Nos.:2020BFH02003,2021BEG02033,2020BEG03008,and 2022BFH02013);the Basic Scientific Research Operating Expenses from the Public Welfare Research Institutes at the Central Level of the Chinese Academy of Medical Sciences,China(Grant No.:2019PT330002);the Ningxia Science and Technology Leading Talent Project,China(Grant No.:KJT2017007);the Natural Science Foundation of Hunan Province,China(Grant No.:2022JJ40698);the School-level Special Talent Launching Project of Ningxia Medical University,China(Grant No.:XT2018015);the Open Bidding for Selecting the Best Candidates Program of Ningxia Medical University,China(Grant No.:XJKF230106).
Rosuvastatin (RVS) is an excellent drug with anti-inflammatory and lipid-lowering properties in the academic and medical fields. However, this drug faces a series of challenges when used to treat atherosclerosis cause...
关键词：HOMOCYSTEINE ATHEROSCLEROSIS Macrophage membrane Prussian blue nanoparticles Rosuvas tatin Gut microbes 
Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis
《Signal Transduction and Targeted Therapy》2024年第9期4048-4065,共18页Han Yan Wenjun Liu Rui Xiang Xin Li Song Hou Luzheng Xu Lin Wang Dong Zhao Xingkai Liu Guoqing Wang Yujing Chi Jichun Yang 
supported by National Natural Science Foundation of China(82300957/82230024/82025008/82070844);Beijing Natural Science Foundation(7212123).
Nonalcoholic fatty liver disease(NAFLD)is a serious threat to public health,but its underlying mechanism remains poorly understood.In screening important genes using Gene Importance Calculator(GIC)we developed previou...
关键词：METABOLISM HEPATIC HOMOCYSTEINE 
Deficiency of betaine-homocysteine methyltransferase activates glucose-6-phosphate dehydrogenase(G6PD)by decreasing arginine methylation of G6PD in hepatocellular carcinogenesis
《Science China(Life Sciences)》2024年第8期1648-1665,共18页Jie Gao Xiaoyi Shi Yaohui Sun Xudong Liu Feng Zhang Chengcheng Shi Xiao Yu Zhiping Yan Long Liu Shizhe Yu Jiacheng Zhang Xiaodan Zhang Shuijun Zhang Wenzhi Guo 
supported by the National Natural Science Foundation of China(82103282);Higher Education Disciplinary Innovation Program(D20036);Henan Province Medical Science and Technology Research Plan(SBGJ202103061,LHGJ20190135);“Science and Technology to create Central Plains”Young Talent Lifting Project(2023HYTP041);Henan Charity General Federation of Hepatobiliary Care Fund(GDXZ2023002).
Betaine-homocysteine methyltransferase(BHMT)regulates protein methylation and is correlated with tumorigenesis;however,the effects and regulation of BHMT in hepatocarcinogenesis remain largely unexplored.Here,we deter...
关键词：HCC BHMT arginine methylation G6PD PPP metabolism 
Effects of homocysteine on cerebral perfusion and cognitive function in patients with arteriosclerotic cerebral small vessel disease
《China Medical Abstracts(Internal Medicine)》2024年第2期127-128,共2页李明旭 
Objective To investigate the effect of homocysteine(Hcy) on cerebral perfusion and cognitive function in patients with arteriosclerotic cerebral small vessel disease(aCSVD).Methods A total of 117 patients with aCSVD w...
关键词：CEREBRAL PERFUSION PATIENTS 
A near-infrared fluorescent probe for visualizing transformation pathway of Cys/Hcy and H2S and its applications in living system
《Chinese Chemical Letters》2024年第5期296-301,共6页Yudi Cheng Xiao Wang Jiao Chen Zihan Zhang Jiadong Ou Mengyao She Fulin Chen Jianli Li 
supported by the National Natural Science Foundation of China(Nos.22077099 and 22171223);the Innovation Capability Support Program of Shaanxi(Nos.2023-CX-TD-75 and 2022KJXX-32);the Technology Innovation Leading Program of Shaanxi(Program No.2023KXJ-209);the Natural Science Basic Research Program of Shaanxi(Nos.2022JQ-151 and 2023-JC-YB-141);Young Talent Fund of Association for Science and Technology in Shaanxi,China(No.SWYY202206);the Shaanxi Fundamental Science Research Project for Chemistry&Biology(Nos.22JHZ010 and 22JHQ080);the Yan’an City Science and Technology Project(No.2022SLZDCY-002).
Sulfydryl-contained(-SH)substances including hydrogen sulfide(H_(2)S),cysteine(Cys),homocysteine(Hcy)and glutathione(GSH)play crucial roles in living systems,and their variations are closely associated with various di...
关键词：Fluorescent probe NEAR-INFRARED Hydrogen sulfide Cysteine/homocysteine Large Stokes shift Dicyanoisophorone Drug-induced liver injury 
A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors
《Acta Pharmaceutica Sinica B》2023年第12期4893-4905,共13页Youchao Deng Xiaosheng Song Iredia D.Iyamu Aiping Dong Jinrong Min Rong Huang 
support from NIH P30 CA023168(Purdue University Center for Cancer Research);the NSERC grant(RGPIN-2021-02728(Jinrong Min)).
Protein arginine methyltransferases(PRMTs)are attractive targets for developing therapeutic agents,but selective PRMT inhibitors targeting the cofactor SAM binding site are limited.Herein,we report the discovery of a ...
关键词：PRMTs Structure based inhibitor design Benzyl urea Noncanonical SAH mimic Homocysteine binding pocket Crystal structure 
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