HYPERHOMOCYSTEINEMIA

作品数：63被引量：342H指数：11
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相关领域：医药卫生更多>>
相关作者：乔杰更多>>
相关机构：南京军区总医院北京大学北京大学第三医院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金中国博士后科学基金更多>>
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Repeated platelet-rich plasma injections improve erectile dysfunction in a rat model of hyperhomocysteinemia被引量：1
《Asian Journal of Andrology》2024年第6期622-627,共6页Zhe Yu Yuan-Zhi Xie Xiao-Lan Huang Su-Zhen Huang Xiang-Min Luo Jin-Xiang Wu 
supported by grants from the Quanzhou Science and Technology Project Funding(No.2021N017S);the Doctoral Nursery Fund of the Second Affiliated Hospital of Fujian Medical University(BS202102).
Platelet-rich plasma (PRP) shows promise as a regenerative modality for mild-to-moderate erectile dysfunction (ED). However, its efficacy in treating severe ED remains unknown. Blood samples from 8-week-old male rats ...
关键词：erectile dysfunction growth factor HYPERHOMOCYSTEINEMIA platelet-rich plasma 
Targeted delivery of rosuvastatin enhances treatment of hyperhomocysteinemia-induced atherosclerosis using macrophage membrane-coated nanoparticles
《Journal of Pharmaceutical Analysis》2024年第9期1301-1319,共19页Dayue Liu Anning Yang Yulin Li Zhenxian Li Peidong You Hongwen Zhang Shangkun Quan Yue Sun Yaling Zeng Shengchao Ma Jiantuan Xiong Yinju Hao Guizhong Li Bin Liu Huiping Zhang Yideng Jiang 
supported by the National Natural Science Foundation of China(Grant Nos.:U21A20343,82160088,81870225,81870332,81700404,82271626,and 82260088);the Natural Science Foundation of Ningxia Autonomous Region,China(Grant Nos.:2020AAC02021,2020AAC02038,and 2022AAC05025);the Key Research and Development Projects in Ningxia Autonomous Region,China(Grant Nos.:2020BFH02003,2021BEG02033,2020BEG03008,and 2022BFH02013);the Basic Scientific Research Operating Expenses from the Public Welfare Research Institutes at the Central Level of the Chinese Academy of Medical Sciences,China(Grant No.:2019PT330002);the Ningxia Science and Technology Leading Talent Project,China(Grant No.:KJT2017007);the Natural Science Foundation of Hunan Province,China(Grant No.:2022JJ40698);the School-level Special Talent Launching Project of Ningxia Medical University,China(Grant No.:XT2018015);the Open Bidding for Selecting the Best Candidates Program of Ningxia Medical University,China(Grant No.:XJKF230106).
Rosuvastatin (RVS) is an excellent drug with anti-inflammatory and lipid-lowering properties in the academic and medical fields. However, this drug faces a series of challenges when used to treat atherosclerosis cause...
关键词：HOMOCYSTEINE ATHEROSCLEROSIS Macrophage membrane Prussian blue nanoparticles Rosuvas tatin Gut microbes 
Severe hyperhomocysteinemia due to MTHFR deficiency caused by a new mutation:A case report and literature review
《中南大学学报（医学版）》2024年第8期1363-1374,共12页YIN Qing YUAN Tianxiang MA Jie TANG Jianguang TAN Xuling YANG Li 
supported by the National Natural Science Foundation(81971696);the Natural Science Foundation of Hunan Province(2022JJ30861),China.
Methylenetetrahydrofolate reductase(MTHFR)deficiency is a rare autosomal recessive genetic disorder caused by mutations in the MTHFR gene,leading to a variety of clinical manifestations.In October 2022,the Second Xian...
关键词：methylenetetrahydrofolate reductase deficiency MTHFR gene HYPERHOMOCYSTEINEMIA genetic metabolism new mutation neuropsychiatric disorders 
Hyperhomocysteinemia and Associated Biological Markers in a Congolese Population of Type 2 Diabetes Mellitus in Brazzaville
《Open Journal of Endocrine and Metabolic Diseases》2024年第6期123-134,共12页V. R. Ikia Monde A. L. M. Boumba E. Mokondjimobe H. Poaty G. Loubano-Voumbi W. F. Ondongo A. G. Mayindou Kimbangu K. Onanga F. Elilie Mawa Ongoth E. Bouenizabila C. Andres H. G. Monabeka 
The search for new biomarkers predictive of type 2 diabetes currently constitutes a research avenue in Bioclinical. Total homocysteine remains a preferred target due to its involvement in the occurrence of degenerativ...
关键词：HYPERHOMOCYSTEINEMIA Biological Markers T2DM BRAZZAVILLE 
Association between Hyperhomocysteinemia and Microangiopathic Complications (Neuropathy and Nephropathy) in Subjects with Type 1 and Type 2 Diabetes
《Journal of Diabetes Mellitus》2023年第4期325-339,共15页Nene Oumou Kesso Barry Soukeyna Gueye Moustapha Djité Pape Matar Kandji Michel Assane Ndour El Hadj Malick Ndour Demba Diedhiou Fatou Gueye-Tall Ndeye Mareme Thioune Najah Fatou Coly Dominique Doupa Maïmouna Ndour Mbaye Philomène Lopez Sall Papa Madieye Gueye 
This prospective case-control study aimed to assess the prevalence of hyperhomocysteinemia and explore its potential correlation with microangiopathic complications, specifically nephropathy and neuropathy, in a cohor...
关键词：HOMOCYSTEINE HYPERHOMOCYSTEINEMIA Diabetes Mellitus Type 1 Diabetes Type 2 Diabetes NEPHROPATHY NEUROPATHY 
Pterostilbene antagonizes homocysteine-induced oxidative stress,apoptosis and lipid deposition in vascular endothelial cells被引量：2
《Food Science and Human Wellness》2023年第5期1683-1692,共10页Qiao Jiang Li Wang Xu Si Yuanyuan Bian Weijia Zhang Huijun Cui Hailong Gui Ye Zhang Bin Li Dehong Tan 
supported by the Zhejiang Lanmei Technology Co.,Ltd.,National Natural Science Foundation of China (U21A20273);“China Agriculture Research System of MOF and MARA (CARS-29)”;the First Batch of Liaoning “Unveiling Leader” Scientific and Technological Projects (2021JH1/10400036)。
Hyperhomocysteinemia(HHcy)causes oxidative stress, induces apoptosis, and leads to damage to the vascular endothelium is the starting point of atherosclerosis. Pterostilbene(Pte)has been reported to have antioxidant a...
关键词：PTEROSTILBENE HYPERHOMOCYSTEINEMIA METHIONINE POLYPHENOLS ATHEROSCLEROSIS 
Hyperhomocysteinemia: Risk Factors and Faster Onset of Degenerative Complications of Type 2 Diabetes in Brazzaville
《Journal of Diabetes Mellitus》2023年第3期257-267,共11页Ikia Monde Valsy Russelh Evariste Bouenizabila Farel Elilie Mawa Ongoth Raissa Laure Mayanda Ohouna Aymande Okoumou-Moko Paulin Kibeke Ghislain Loubano-Voumbi Luc Magloire Boumba Anicet Wilson Fabrice Ondongo Mayindou Kimbangu Archimède Gotran Tienelle Freiss Mabiala Wann Koumou Onanga Thierry Raoul Ngombea Benjamin Longo Mbenza Edouard Ngou Milama Christian Andres Etienne Mokondjimobe Henri Germain Monabeka 
Background: Type 2 diabetes (T2D) remains a major global public health problem. This complex metabolic disorder can lead to various complications, including cardiovascular diseases (leading cause of death) in T2D. Amo...
关键词：HYPERHOMOCYSTEINEMIA Patients with T2D Risk Factor Acceleration Factor Degenerative Complications CONGO 
Evaluation of Plasma Homocysteine Levels in Type II Diabetes and Hypertensive Patients Attending University of Port Harcourt Teaching Hospital, Nigeria
《Journal of Biosciences and Medicines》2023年第5期30-39,共10页Donatus Onukwufor Onwuli Helen Anthony Waribo Eberechkwu Okwuchi Anyalebechi Loveth Ukamaka Nwafor 
Background: Homocysteine is an important non-protein amino acid, very useful in all methylation reactions occurring in the body as the precursor of the sole methyl group donor S-Adenosyl-methionine (SAM). However, ele...
关键词：Hypertensives Diabetes Mellitus HOMOCYSTEINE HYPERHOMOCYSTEINEMIA 
B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis被引量：8
《Signal Transduction and Targeted Therapy》2023年第4期1926-1941,共16页Xing Du Xiaolong Ma Ying Tan Fangyu Shao Chun Li Yang Zhao Yutong Miao Lulu Han Guohui Dang Yuwei Song Dongmin Yang Zhenling Deng Yue Wang Changtao Jiang Wei Kong Juan Feng Xian Wang 
the National Natural Science Foundation of China(No.31872787,82070462,81921001,91939105,and 82170476);the Natural Science Foundation of Beijing Municipality,China(No.M21008).
Hyperhomocysteinemia(HHcy)is a risk factor for chronic kidney diseases(CKDs)that affects about 85%CKD patients.HHcy stimulates B cells to secrete pathological antibodies,although it is unknown whether this pathway med...
关键词：HYPERTENSIVE glomerular PEROXIDATION 
Single-cell RNA sequencing reveals B cell-T cell interactions in vascular adventitia of hyperhomocysteinemia-accelerated atherosclerosis被引量：2
《Protein & Cell》2022年第7期540-547,共8页Xiaolong Ma Jiacheng Deng Lulu Han Yuwei Song Yutong Miao Xing Du Guohui Dang Dongmin Yang Bitao Zhong Changtao Jiang Wei Kong Qingbo Xu Juan Feng Xian Wang 
This work was supported by grants from National Natural Science Foundation of China(31872787,91739303,91939105,81770445,81921001,and 82170476);Natural Science Foundation of Beijing,China(No.M21008).
Dear Editor Cardiovascular disease(CVD)is the leading cause of death around the world(Truelsen,et al.,2015).Atherosclerosis,the dominant underlying cause of CVD,is a chronic inflam-matory disease characterized by lipi...
关键词：ATHEROSCLEROSIS al. metabolism 
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