Homocysteine Levels and Determinants among Chinese Women at Mid-pregnancy, Late Pregnancy, and Postpartum  

作　　者：Zhenyu Guo Hongtian Li Yirui Ma Ying Meng Yubo Zhou Jianmeng Liu 

机构地区：[1]Institute of Reproductive and Child Health,National Health Commission Key Laboratory of Reproductive Health,Peking University Health Science Center,Beijing 100191,China [2]Department of Epidemiology and Biostatistics,School of Public Health,Peking University Health Science Center,Beijing 100191,China [3]Center for Intelligent Public Health,Institute for Artificial Intelligence,Peking University,Beijing 100191,China

出　　处：《Biomedical and Environmental Sciences》2025年第4期459-468,共10页生物医学与环境科学(英文版)

摘　　要：Objective Data on homocysteine(Hcy) status and its determinants are limited among women during pregnancy and postpartum. This cross-sectional study aimed to investigate Hcy levels during pregnancy and postpartum, and to explore the determinants like geographic factor.Methods This study was conducted in women at mid-pregnancy, late-pregnancy and postpartum from southern, central and northern China. Approximately 132 women were included in each stratum by the three phases and regions. Plasma Hcy concentrations were assessed using high-performance liquid chromatography(HPLC), with hyperhomocysteinemia defined as > 10.0 μmol/L. Quantile regression was to estimate medians and interquartile ranges(IQRs), and logistic regression to examine the determinants of hyperhomocysteinemia.Results For 1,190 women included, the median(IQR) Hcy concentration was 5.66(4.62, 7.37) μmol/L.The adjusted median in mid-pregnancy, late-pregnancy and postpartum women was 4.75(4.13, 5.54),5.72(4.81, 6.85) and 7.09(5.65, 8.75) μmol/L, respectively, showing an increasing trend(P < 0.001). This increasing trend persisted across the three regions. Higher Hcy concentrations were observed in women residing in northern region and those with younger age or lower economic status. A total of 106(8.9%)women had hyperhomocysteinemia, with a higher prevalence in those residing in northern region(16.0%), or in postpartum women(16.5%).Conclusion Hcy levels, varying with geographic region, maternal age and economic status, are increased from mid-pregnancy to late-pregnancy and postpartum, indicating a need to monitor Hcy levels in pregnant and postpartum women to control potential risks related to elevated Hcy levels.

关 键 词：HOMOCYSTEINE HYPERHOMOCYSTEINEMIA Pregnancy and postpartum Determinants 

分 类 号：R714.7[医药卫生—妇产科学]