Serum homocysteine showed potential association with cognition and abnormal gut microbiome in major depressive disorder  

作　　者：Chen-Chen Xu Wen-Xuan Zhao Yu Sheng Ya-Jun Yun Ting Ma Ning Fan Jia-Qi Song Jun Wang Qi Zhang 

机构地区：[1]Department of Psychiatry,The Affiliated Wuxi Mental Health Center of Nanjing Medical University,Wuxi 214151,Jiangsu Province,China [2]Department of Psychiatry,Beijing Huilongguan Hospital,Peking University Huilongguan Clinical Medical School,Beijing 100096,China [3]Department of Psychiatry,Chinese People’s Liberation Army Unit 94710,Wuxi 214141,Jiangsu Province,China [4]Department of Psychiatry,The Affiliated Mental Health Center of Jiangnan University,Wuxi 214151,Jiangsu Province,China

出　　处：《World Journal of Psychiatry》2025年第3期234-248,共15页世界精神病学杂志(英文)

基　　金：Supported by the Wuxi Municipal Health Commission Youth Fund Project,No.Q202268;Wuxi Scientific and technological breakthrough of“Light of the Taihu Lake”(Basic Research),No.K20221039;Jiangsu Shuangchuang Doctoral Program,No.JSSCBS20221991;Beijing Municipal Administration of Hospital Incubating Program,No.PX2023070 and No.PX2024072;Capital’s Funds for Health Improvement and Research,No.SF2024-4-2134;Beijing Hospitals Authority Youth Program,No.QML20232003;the Top Talent Support Program for young and middle-aged people of Wuxi Health Committee,No.HB2023089.

摘　　要：BACKGROUND Cognitive impairment is one of the common clinical manifestations of depression,causing negative distress to patients.Elevated homocysteine(Hcy)concentrations and gut microbiome dysfunction may be observed in patients with depression.AIM To investigate the relationship between Hcy,microbiome,and cognition in depressive patients.METHODS We recruited 67 patients with major depressive disorder(MDD)(MDD group)and 94 healthy controls(HCs)individuals(HCs group).Serum Hcy levels were determined using the enzyme circulation method.16s rRNA sequencing was used to classify and identify the fecal bacteria.17 Hamilton depression rating scale and MATRICS consensus cognitive battery were used to evaluate mood states and cognition in patients with MDD. Correlation analysis was performed to explore the correlation between fecal flora,Hcy, and depressive cognitive function.RESULTSElevated serum levels of Hcy were seen in patients with MDD compared to healthy individuals. Patients withMDD indicated significant decreases in cognitive scores (P < 0.001) in six modules: Speed of processing, workingmemory, visual learning, reasoning and problem-solving, social cognition, and total scores. Hcy levels showed anegative correlation with processing speed, social cognition, and total MDD scores (P < 0.05). Hcy was alsosignificantly negatively correlated with Alistipes, Ruminococcae, Tenericides, and Porphyromonas (P < 0.05).CONCLUSIONOur results highlight that Hcy was correlated with cognition and gut microbiome in MDD. This interaction may berelated to the physiological and pathological mechanisms underlying cognitive deficits in depression.

关 键 词：HOMOCYSTEINE MICROBIOME Intestinal flora Gut microbiota Gut-brain axis Major depressive disorder Cognitive function Cognitive impairment 

分 类 号：R74[医药卫生—神经病学与精神病学]