Viscosity-responsive signal amplification dual-modal probe triggered by cysteine/homocysteine for monitoring diabetic liver damages and repair processes  

作　　者：Sixin Ai Wenxiu Li Huayong Zhu Yang Wan Weiying Lin 

机构地区：[1]Institute of Optical Materials and Chemical Biology,Guangxi Key Laboratory of Electrochemical Energy Materials,School of Chemistry and Chemical Engineering,Guangxi University,Nanning 530004,China

出　　处：《Chinese Chemical Letters》2025年第3期328-334,共7页中国化学快报(英文版)

基　　金：financially supported by the National Natural Science Foundation of China(Nos.21877048,22077048,and 22277014);Guangxi Natural Science Foundation(Nos.2021GXNSFDA075003,AD21220061);the Startup Fund of Guangxi University(No.A3040051003).

摘　　要：Diabetic liver injury is a widespread complication of diabetes and carries a high risk to liver function.Therefore,early diagnosis of diabetic liver injury is of great significance for providing quality of life for diabetic patients.Most of the activated dual-modal probes are usually activated by single factor stimulation,which greatly reduces the diagnostic accuracy of liver injury.Here,a novel cysteine(Cys)/homocysteine(Hcy)and viscosity-enhanced dual-modal probe DAL was developed for the first time to monitor diabetic liver injury and its repair process.In the presence of Cys/Hcy,the near-infrared fluorescence(NIRF)and photoacoustic(PA)signals of the probe DAL were activated,with further signal enhancement in high viscosity environments.This Cys/Hcy and viscosity cascade probe exhibits heightened sensitivity and enhanced anti-interference capabilities,contributing to the advancement of liver injury diagnosis accuracy.In addition,the probe DAL shows exceptional mitochondrial targeting ability,enabling sensitive monitoring of Cys/Hcy and viscosity alterations within mitochondria.Based on NIRF/PA dual-modal imaging technology,the probe was successfully used for the first time in a mouse diabetic liver injury model to evaluate the extent of liver damage and the repair process by tracking the levels of Cys/Hcy and viscosity.Therefore,the two-factor activated dual-modal probe developed in this study provides a powerful instrument for accurate diagnosis and efficacy evaluation of complications related to diabetes.

关 键 词：Cysteine/homocysteine Viscosity responsive Near-infrared fluorescence Photoacoustic imaging Fluorescence imaging 

分 类 号：R73[医药卫生—肿瘤] R587.1[医药卫生—临床医学]