CERAMIDES

作品数：19被引量：34H指数：4
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相关领域：医药卫生更多>>
相关作者：王琪赵丽娜邢怡唐毅贾建平更多>>
相关机构：首都医科大学宣武医院中山医科大学中国科学院北京大学更多>>
相关期刊：《World Journal of Hepatology》《Translational Neurodegeneration》《National Science Review》《Chinese Journal of Chemical Engineering》更多>>
相关基金：国家自然科学基金中国博士后科学基金更多>>
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Cord blood ceramides facilitate early risk identification into childhood metabolic health
《National Science Review》2024年第10期173-177,共5页Jia Zheng Sin Man Lam Binhua Jiang Lili Mao Jieying Liu Qian Zhang Miao Yu Wei Ling Florence Lim Claudia H.T.Tam William L.Lowe Jr. Wing Hung Tam Ying Gao Junqing Zhang Ronald C.W.Ma Xinhua Xiao Guanghou Shui 
supported by the National Natural Science Foundation of China(82170854,81870579,81870545,81800703,2357308,32321004,92357308);National High Level Hospital Clinical Research Funding(2022-PUMCH-C-019);Beijing Nova Program(Z201100006820117 and 20220484181);Beijing Municipal Science&Technology Commission(Z201100005520011);Peking University Clinical Scientist Training Program(BMU2023PYJH022);Beijing Municipal Natural Science Foundation(7202163,7184252);Hong Kong Research Grants Council Research Impact Fund(R4012-18);University Grants Committee Research Grants Matching Scheme.;The HAPO follow-up study in Hong Kong was supported by Research Grants Council of HKSAR(CUHK473408,CUHK471713);the Health and Medical Research Fund(Ref-13140761)of the Hong Kong Food and Health Bureau。
The Developmental Origins of Health and Disease(DOHaD)theory highlights the impact of intrauterine exposures commencing from pre-conception that significantly affect health trajectories throughout later life[1].Our pr...
关键词：IMPAIRED finding identification 
Intervention effect of Cigu Xiaozhi prescription(慈菇消脂方)on ceramide lipoapoptosis in non-alcoholic fatty liver disease
《Journal of Traditional Chinese Medicine》2024年第1期63-69,共7页YANG Shaojun MA Yanhua BAI Zhouxia YU Ye FANG Buwu ZHANG Li WANG Li 
Natural Science Foundation-funded Project:the Interaction of mi RNAs and Hh Signaling Pathway in NASH Related Liver Fibrosis and the Intervention of Sagittaria Xiaozhi Pill(No.81860821);Toxin and Eliminating Phlegm Intervention Ceramide and Induced iNOS Nonalcoholic Fatty Liver Disease Fat Research of Apoptosis Signaling(No.81460710)。
OBJECTIVE:To explore the mechanism of the Chinese medicine Cigu Xiaozhi prescription(慈菇消脂方,CGXZ)in the treatment of the non-alcoholic fatty liver disease(NAFLD)by detoxification and phlegm-reducing,the effect of ...
关键词：non-alcoholic fatty liver disease CERAMIDES Cigu Xiaozhi prescription detoxification and phlegm removal 
Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer’s disease mouse model被引量：2
《Translational Neurodegeneration》2023年第1期70-89,共20页Carolyn Tallon Benjamin J.Bell Medhinee M.Malvankar Pragney Deme Carlos Nogueras-Ortiz Erden Eren Ajit G.Thomas Kristen R.Hollinger Arindom Pal Maja Mustapic Meixiang Huang Kaleem Coleman Tawnjerae R.Joe Rana Rais Norman J.Haughey Dimitrios Kapogiannis Barbara S.Slusher 
supported by the National Institute of Health Grants R01 AG059799(to BSS),R01AG057420 and R01MH131219(to NJH),P30 MH075673(to NJH and BSS);a grant from the Tau Consortium and Alzheimer’s Association(T-PEP-18-579974C,to BSS);a grant from the Richman Family Precision Medicine Center of Excellence in Alzheimer’s disease(to BSS and DK).KC and TRJ were Funded by NIH R25GM109441(Hopkins PREP).
Background Cognitive decline in Alzheimer’s disease(AD)is associated with hyperphosphorylated tau(pTau)propagation between neurons along synaptically connected networks,in part via extracellular vesicles(EVs).EV biog...
关键词：Alzheimer’s disease Extracellular vesicles Neutral sphingomyelinase 2 TAU CERAMIDE 
Dysregulated ceramides metabolism by fatty acid 2-hydroxylase exposes a metabolic vulnerability to target cancer metastasis被引量：5
《Signal Transduction and Targeted Therapy》2022年第11期4235-4248,共14页Xuantong Zhou Furong Huang Gang Ma Wenqing Wei Nan Wu Zhihua Liu 
National Key R&D Program of China(2021YFC2501000,2020YFA0803300);National Natural Science Foundation of China(82030089,82188102);CAMS Innovation Fund for Medical Sciences(2021-1-I2M-018,2021-I2M-1-067);China Postdoctoral Science Foundation(2021M700007);Sanming Project of Medicine in Shenzhen(No.SZSM201812062);Guangdong Basic and Applied Basic Research Foundation(2019B030302012).
Whereas it is appreciated that cancer cells rewire lipid metabolism to survive and propagate,the roles of lipid metabolism in metastasis remain largely unknown.In this study,using esophageal squamous cell carcinoma(ES...
关键词：METASTASIS METABOLISM cancer 
Duodenal-jejunal bypass reduces serum ceramides via inhibiting intestinal bile acid-farnesoid X receptor pathway被引量：1
《World Journal of Gastroenterology》2022年第31期4328-4337,共10页Zhi-Qiang Cheng Tong-Ming Liu Peng-Fei Ren Chang Chen Yan-Lei Wang Yong Dai Xiang Zhang 
BACKGROUND Bile acids play an important role in the amelioration of type 2 diabetes following duodenal-jejunal bypass(DJB).Serum bile acids are elevated postoperatively.However,the clinical relevance is not known.Bile...
关键词：Bariatric surgery Duodenal-jejunal bypass Farnesoid X receptor CERAMIDE Bile acids Liver fat accumulation 
Deciphering lipid dysregulation in ALS:from mechanisms to translational medicine
《Translational Neurodegeneration》2022年第1期192-218,共27页Ira Agrawal Yong Shan Lim Shi-Yan Ng Shuo-Chien Ling 
National Medical Research Council(NMRC/OFIRG/0042/2017);National Research Foundation(NRF2019-NRF-ISF003-3221);Ministry of Education(MOE-T2EP30220-0029),Singapore to S.-C.L.
Lipids,defined by low solubility in water and high solubility in nonpolar solvents,can be classified into fatty acids,glycerolipids,glycerophospholipids,sphingolipids,and sterols.Lipids not only regulate integrity and...
关键词：Amyotrophic lateral sclerosis SPHINGOLIPIDS TRIGLYCERIDES Phospholipids Cholesterol esters Fatty acids CERAMIDES Arachidonic acid LYSOPHOSPHATIDYLCHOLINE EICOSANOIDS 
Lipidomics in non-alcoholic fatty liver disease被引量：7
《World Journal of Hepatology》2020年第8期436-450,共15页Sofia Kartsoli Christina E Kostara Vasilis Tsimihodimos Eleni T Bairaktari Dimitrios K Christodoulou 
Non-alcoholic fatty liver disease(NAFLD),the most common chronic liver disorder in Western countries,comprises steatosis to nonalcoholic steatohepatitis(NASH),with the latter having the potential to progress to cirrho...
关键词：LIPIDOMICS Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis LIPOTOXICITY Fatty acids CERAMIDES 
Role of dihydroceramides in the progression of acute-on-chronic liver failure in rats被引量：3
《Chinese Medical Journal》2020年第2期198-204,共7页Fang-Fang Li Ning Liu Wei Liu Mei Li Fan Zhang Zhen Dong Jin-Lan Zhang Hua Sun 
This work was supported by the National Natural Science Foundation of China(No.81573487);the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(No.2017-12M-1-013);the Drug Innovation Major Project(No.2018ZX09711001-003-011).
Background:Previously,dihydroceramide(d18:0/24:0)(dhCer(d18:0/24:0))was reported to be a potential biomarker for acute-onchronic liver failure(ACLF)prognosis.In this study,we further explored the role of dhCer(d18:0/2...
关键词：N-(4-hydroxyphenyl)retinamide Acute-on-chronic LIVER FAILURE CERAMIDES Dihydroceramides 
The Flow of Information from Nucleus to Golgi Is Contingent upon Nuclear Membrane Synthesis and Protraction of the Ceramide-Containing Membrane to Endoplasmic Reticulum被引量：1
《Advances in Biological Chemistry》2018年第3期47-68,共22页Amalia Slomiany Bronislaw L. Slomiany 
The nucleus-initiated augmentation of ER membrane is reflected in a coordinated synthesis and intercalation of the explicit proteins and lipids required for the replacement, repair and function of the cell and its org...
关键词：NUCLEUS MEMBRANE Biogenesis GOLGI Secretory Pathway Serine Palmitoyl TRANSFERASE CERAMIDES SYNTHESIS in Nuclear MEMBRANE Organelle-Customized ER Transport Vesicles 
Soft coral Cespitularia stolonifera:New cytotoxic ceramides and gastroprotective activity被引量：1
《Chinese Journal of Natural Medicines》2017年第2期105-114,共10页Abdelsamed I.Elshamy Walaa A.El-Kashak Heba M.I.Abdallah Abdelrazik H.Farrag Mahmoud I.Nassar 
supported by the Science and Technology Development Fund(STDF)(No.6554)
In the present study, a new ceramide, namely 2S, 3R-4E, 8E-2-(heptadecanoylamino)-heptadeca-4, 8-diene-1, 3-diol(1), along with four known steroids, including 24-methylcholesta-5, 24(28)-diene-3β-ol(2), 24-methylchol...
关键词：Cespitularia stolonifera CERAMIDE STEROIDS Anticancer leading constituents Antiulcer activity 
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