LYSOPHOSPHATIDYLCHOLINE

作品数：26被引量：42H指数：4
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相关领域：医药卫生更多>>
相关作者：陈剑雄陈维洲鲁蓉汤聿海邓汉武更多>>
相关机构：中国科学院湖南医科大学第二军医大学北京师范大学更多>>
相关期刊：《World Journal of Biological Chemistry》《National Science Review》《Advances in Bioscience and Biotechnology》《Acta Biochimica et Biophysica Sinica》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier
《Neural Regeneration Research》2025年第8期2133-2152,共20页Yilun Ma Taiwei Dong Fei Luan Juanjuan Yang Feng Miao Peifeng Wei 
supported by the National Natural Science Foundation of China,No.82104412(to TD);Shaanxi Provincial Key R&D Program,No.2023-YBSF-165(to TD);the Natural Science Foundation of Shaanxi Department of Science and Technology,No.2018JM7022(to FM);Shaanxi Provincial Key Industry Chain Project,No.2021ZDLSF04-11(to PW)。
The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the bloo...
关键词：blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells LYSOPHOSPHATIDYLCHOLINE major facilitator superfamily domain containing 2A(MFSD2A) TRANSCYTOSIS 
Plasma Lysophosphatidylcholine and Phospholipase A2 Activity in Chagas Disease Patients: A Comparative Analysis
《Advances in Bioscience and Biotechnology》2024年第8期462-473,共12页Maria Fernanda Carvalho de Araujo Bruna Maria Ferreira Iaciura Fillipe Araujo de Sá Georgia Correa Atella 
Chagas disease (CD) affects 21 countries in the Americas and is caused by the parasite Trypanosoma cruzi. A key molecule involved in CD is lysophosphatidylcholine (LPC), which has been studied in various contexts: in ...
关键词：LYSOPHOSPHATIDYLCHOLINE Phospholipase A2 PLASMA Chagas Disease Idiopathic Dilated Cardiomyopathy 
GITR exacerbates lysophosphatidylcholine-induced macrophage pyroptosis in sepsis via posttranslational regulation of NLRP3被引量：1
《Cellular & Molecular Immunology》2024年第7期674-688,共15页Siping Liang Jinyu Zhou Can Cao Yiting Liu Siqi Ming Xi Liu Yuqi Shang Juanfeng Lao Qin Peng Jiahui Yang Minhao Wu 
supported by grants from the National Natural Science Foundation of China(31970893,32270976);the Natural Science Foundation of Guangdong Province(2022A1515012541);the Guangdong Natural Science Fund for Distinguished Young Scholars(2016A030306004);the Fundamental Research Funds for the Central Universities(2023kypt18,2023ptpy67,19ykzd39,19ykpy43);the China Postdoctoral Science Foundation(2022M723661);the 111 Project(No.B12003,B13037);the Open Project of the Key Laboratory of Tropical Disease Control(Sun Yat-sen University),Ministry of Education(2020kfkt08).
The NLRP3 inflammasome functions as an inflammatory driver,but its relationship with lipid metabolic changes in early sepsis remains unclear.Here,we found that GITR expression in monocytes/macrophages was induced by l...
关键词：GITR MACROPHAGE NLRP3 inflammasome SEPSIS Posttranslational modification 
Tailoring therapeutics via a systematic beneficial elements comparison between photosynthetic bacteria-derived OMVs and extruded nanovesicles被引量：1
《Bioactive Materials》2024年第6期48-61,共14页Tingshan Xiao Yichuan Ma Ziyang Zhang Yixin Zhang Yu Zhao Xiaohan Zhou Xueyi Wang Kun Ge Junshu Guo Jinchao Zhang Zhenhua Li Huifang Liu 
supported by the National Natural Science Foundation of China(32322045,32271420,31971304,and 21977024);The Beijing-Tianjin-Hebei Basic Research Cooperation Project(19JCZDJC64100);Cross-Disciplinary Project of Hebei University(DXK201916);One Hundred Talent Project of Hebei Province(E2018100002);National High-End Foreign Expert Recruitment Plan(G2022003007L);Science Fund for Creative Research Groups of Nature Science Foundation of Hebei Province(B2021201038);Natural Science Foundation of Hebei Province(B2023201108);Hebei Province Higher Education Science and Technology Research Project(JZX2023001).
Photosynthetic bacteria(PSB)has shown significant potential as a drug or drug delivery system owing to their photothermal capabilities and antioxidant properties.Nevertheless,the actualization of their potential is im...
关键词：Photosynthetic bacteria Outer membrane vesicles Bacteria-derived nanovesicles ANTITUMOR LYSOPHOSPHATIDYLCHOLINE 
Lysophosphatidylcholine binds α-synuclein and prevents its pathological aggregation被引量：1
《National Science Review》2024年第6期112-121,共10页Chunyu Zhao Jia Tu Chuchu Wang Wenbin Liu Jinge Gu Yandong Yin Shengnan Zhang Dan Li Jiajie Diao Zheng-Jiang Zhu Cong Liu 
supported by the Major State Basic Research Development Program(2019YFE0120600 to C.L.);the National Key R&D Program of China(2018YFA0800902 to Z.J.Z.);the National Natural Science Foundation of China(82188101 and 32171236 to C.L.;92353302 and 32170683 to D.L.);the Science and Technology Commission of Shanghai Municipality(STCSM)(22JC1410400 to C.L.);the Shanghai Pilot Program for Basic Research-Chinese Academy of Sciences,Shanghai Branch(CYJ-SHFY-2022-005 to C.L.);the CAS Project for Young Scientists in Basic Research(YSBR-095 to C.L.);the Shanghai Municipal Science and Technology Major Project(to Z.J.Z.);the Shanghai Basic Research Pioneer Project(to C.L.and Z.J.Z.).
Accumulation of aggregated α-synuclein (α-syn) in Lewy bodies is the pathological hallmark of Parkinson’sdisease (PD). Genetic mutations in lipid metabolism are causative for a subset of patients withParkinsonism. ...
关键词：Α-SYNUCLEIN Parkinson’s disease LYSOPHOSPHATIDYLCHOLINE AGGREGATION 
Lpcat3 deficiency promotes palmitic acid-induced 3T3-L1 mature adipocyte inflammation through enhanced ROS generation
《Acta Biochimica et Biophysica Sinica》2023年第1期117-130,共14页Jiachun Hu Yan Deng Tingbo Ding Jibin Dong Yuning Liang Bin Lou 
This work was supported by the grant from the National Natural Science Foundation of China(No.31770864)。
Phosphatidylcholines(PCs)are major phospholipids in the mammalian cell membrane.Structural remodeling of PCs is associated with many biological processes.Lysophosphatidylcholine acyltransferase 3(Lpcat3),which catalyz...
关键词：ADIPOCYTE INFLAMMATION lysophosphatidylcholine acyltransferase 3(Lpcat3) obesity 
Deciphering lipid dysregulation in ALS:from mechanisms to translational medicine
《Translational Neurodegeneration》2022年第1期192-218,共27页Ira Agrawal Yong Shan Lim Shi-Yan Ng Shuo-Chien Ling 
National Medical Research Council(NMRC/OFIRG/0042/2017);National Research Foundation(NRF2019-NRF-ISF003-3221);Ministry of Education(MOE-T2EP30220-0029),Singapore to S.-C.L.
Lipids,defined by low solubility in water and high solubility in nonpolar solvents,can be classified into fatty acids,glycerolipids,glycerophospholipids,sphingolipids,and sterols.Lipids not only regulate integrity and...
关键词：Amyotrophic lateral sclerosis SPHINGOLIPIDS TRIGLYCERIDES Phospholipids Cholesterol esters Fatty acids CERAMIDES Arachidonic acid LYSOPHOSPHATIDYLCHOLINE EICOSANOIDS 
Lysophosphatidylcholine acyltransferase 1 is involved in the regulation of exosome secretion and uptake in colorectal cancer cells
《BIOCELL》2022年第2期453-462,共10页HAIZHENG LIU SHAOFEI CHANG 
Lysophosphatidylcholine acyltransferase 1(LPCAT1)is a phospholipid acyltransferase that promotes phospholipid synthesis and plasma membrane reconstruction.Exosomes play an important role in tumor metastasis.The releas...
关键词：LPCAT1 EXOSOMES Colorectal cancer 
Baseline effects of lysophosphatidylcholine and nerve growth factor in a rat model of sciatic nerve regeneration after crush injury被引量：5
《Neural Regeneration Research》2018年第5期846-853,共8页Ryan L.Wood Keaton S.Karlinsey Austin D.Thompson Mark N.Rigby Greggory D.Boatright William G.Pitt Beverly L.Roeder Scott C.Steffensen Alonzo D.Cook 
Funding for animal care and supplies was provided by Brigham Young University,the Don B.Olsen Mentorship to RLW;a Brigham Young University Office of Research and Creative Activities Student Mentored Research Grant to KSK
Schwann cells play a major role in helping heal injured nerves. They help clear debris, produce neurotrophins, upregulate neurotrophin receptors, and form bands of Büngner to guide the healing nerve. But nerves do no...
关键词：LYSOPHOSPHATIDYLCHOLINE neurotrophic factor growth factor sciatic nerve CRUSH peripheral nerve REGENERATION 
Association between dairy intake,lipids and vascular structure and function in diabetes
《World Journal of Diabetes》2017年第5期202-212,共11页Kristina S Petersen Jennifer B Keogh Natalie Lister Jacquelyn M Weir Peter J Meikle Peter M Clifton 
the Heart Foundation and the Government of South Australia,No.CR 12A 6750 to Keogh JB;NHMRC Principal Research Fellowship,No.APP1125691 to Clifton PM;NHMRC Senior Research Fellowship,No.APP1042095 to Meikle PJ;an Australian Postgraduate Award,No.138093 to Petersen KS;a University of South Australia Postgraduate Award,No.128123 to Lister N
AIM To determine lipid species that change in response to a change in dairy consumption. In addition, to investigate whether dairy associated lipid species are correlated with changes in measures of vascular structure...
关键词：LIPIDS PHOSPHOLIPIDS Atherosclerosis DAIRY LYSOPHOSPHATIDYLCHOLINE LIPIDOMICS Carotid intima media thickness Pulse wave velocity DIABETES 
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