funded by the National Natural Science Foundation of China(No.82370742);the Key Program of Jiangsu Health and Health Committee(No.ZD2022045).
Background:Renal osteodystrophy(ROD)is a skeletal pathology associated with chronic kidney disease-mineral and bone disorder(CKD-MBD)that is characterized by aberrant bone mineralization and remodeling.ROD increases t...
supported by the Guangxi Science and Technology Project (AD20297088);the National Natural Science Foundation of China (32272316);the Beijing Innovation Team of Livestock Industry Technology System (BAIC05-2022)
Prenatal overweight/obesity(OW/OB)can alter colostrum lipid patterns,thereby affecting the lipid metabolism and even the cognitive and healthy development of infants.However,studies on changes in colostrum lipids in t...
supported by grants from National Key R&D Program of China(2018YFA0506900,2018YFA0800901);the National Natural Science Foundation of China(NSFC92057202);the Chinese Academy of Sciences(XDB39050900).
Sphingolipids not only exert structural roles in cellular membranes,but also act as signaling molecules in various physiological and pathological processes.A myriad of studies have shown that abnormal levels of sphing...
the support from the National Science Foundation(CBET-2112201)。
The SH-SY5Y,neuroblastoma cell line,is a common in vitro model used to study physiological neuronal function and the neuronal response to different stimuli,including exposure to toxic chemicals.These cells can be diff...
financed by the National Key R&D Program of China(No.2018YFC0311201);the Fundamental Research Funds for the Central Universities of China(No.202012018).
The sea cucumber phospholipids(SC-PLs)are involved in regulating multiple chronic lipid metabolism disorders,but their mechanism remains unknown.Herein,ethanol diet-induced C57BL/6N mice were established as alcoholic ...
supported by grants from the National Natural Science Foundation of China(grant no.31970276 and grant no.32270271)to D.R。
Sphingolipids are the structural components of membrane lipid bilayers and act as signaling molecules in many cellular processes.Serine palmitoyltransferase(SPT)is the first committed and rate-limiting enzyme in the d...
This work was supported by the National Natural Science Foundation of China(No.82070642)to JZ;the Guangdong Province Science and Technology Program(No.2020A1515011205)to KW;the Guangdong Province Science and Technology Program(No.2021A1515012146)to CJL;the President Foundation of Nanfang Hospital,Southern Medical University(No.2018C029)to JPQ.
Background:Lipid dysregulation plays a fundamental role in nonalcoholic steatohepatitis(NASH),which is an emerging critical risk factor that aggravates hepatic ischemia/reperfusion(I/R)injury.However,the specific lipi...
Supported by Science and Technology Innovation Project of Hunan Academy of Agricultural Sciences (2021CX32)。
The most predominant sphingoilipids bases are phytosphingosine(phyto-sph) and phytosphingosine-1-phosphate(phyto-S1 P), followed by dihydrosphingosine(dh-sph) and dihydroshingosine-1-phosphate(dh-S1 P). In this study,...
This study was supported by Department of Veteran Affairs Merit Award(No. I01BX004033);Research Career Scientist Award(No. IK6BX0094477);National Institutes of Health Grant(Nos. R01 DK104893, R01DK-057543, and R21 AA026629-01)。
Non-alcoholic fatty liver disease (NAFLD) is one of the fastest-growing diseases, and its global prevalence is estimated to increase >50% by 2030. NAFLD is comorbid with metabolic syndrome, obesity, type 2 diabetes, a...
National Medical Research Council(NMRC/OFIRG/0042/2017);National Research Foundation(NRF2019-NRF-ISF003-3221);Ministry of Education(MOE-T2EP30220-0029),Singapore to S.-C.L.
Lipids,defined by low solubility in water and high solubility in nonpolar solvents,can be classified into fatty acids,glycerolipids,glycerophospholipids,sphingolipids,and sterols.Lipids not only regulate integrity and...