SPHINGOLIPIDS

作品数:32被引量:78H指数:5
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相关领域:医药卫生生物学更多>>
相关作者:陈光英朱峰林永成更多>>
相关机构:佛山科学技术学院中山大学海南师范大学南昌大学更多>>
相关期刊:《Advances in Biological Chemistry》《Marine Science Bulletin》《Chinese Medical Journal》《World Journal of Cardiology》更多>>
相关基金:国家自然科学基金国家高技术研究发展计划更多>>
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Role of sphingolipid metabolism signaling in a novel mouse model of renal osteodystrophy based on transcriptomic approach
《Chinese Medical Journal》2025年第1期68-78,共11页Yujia Wang Yan Di Yongqi Li Jing Lu Bofan Ji Yuxia Zhang Zhiqing Chen Sijie Chen Bicheng Liu Rining Tang 
funded by the National Natural Science Foundation of China(No.82370742);the Key Program of Jiangsu Health and Health Committee(No.ZD2022045).
Background:Renal osteodystrophy(ROD)is a skeletal pathology associated with chronic kidney disease-mineral and bone disorder(CKD-MBD)that is characterized by aberrant bone mineralization and remodeling.ROD increases t...
关键词:Chronic kidney disease-mineral and bone disorder Renal osteodystrophy ADENINE PHOSPHATE TRANSCRIPTOMICS SPHINGOLIPIDS 
Effects of excessive body fat on colostrum lipid patterns: overweight/obese vs. normal weight mothers
《Food Science and Human Wellness》2024年第6期3708-3717,共10页Qian Liu Yan Liu Di Yang Yanpin Liu Yan Liu Weicang Qiao Juncai Hou Yaling Wang Minghui Zhang Kai Yang Xiaofei Fan Ziqi Li Junying Zhao Lijun Chen 
supported by the Guangxi Science and Technology Project (AD20297088);the National Natural Science Foundation of China (32272316);the Beijing Innovation Team of Livestock Industry Technology System (BAIC05-2022)
Prenatal overweight/obesity(OW/OB)can alter colostrum lipid patterns,thereby affecting the lipid metabolism and even the cognitive and healthy development of infants.However,studies on changes in colostrum lipids in t...
关键词:OVERWEIGHT/OBESITY COLOSTRUM Maternal diet Fat reserves GLYCERIDES PHOSPHOLIPIDS SPHINGOLIPIDS 
Emerging roles and therapeutic potentials of sphingolipids in pathophysiology:emphasis on fatty acyl heterogeneity被引量:7
《Journal of Genetics and Genomics》2024年第3期268-278,共11页Jinming Mu Sin Man Lam Guanghou Shui 
supported by grants from National Key R&D Program of China(2018YFA0506900,2018YFA0800901);the National Natural Science Foundation of China(NSFC92057202);the Chinese Academy of Sciences(XDB39050900).
Sphingolipids not only exert structural roles in cellular membranes,but also act as signaling molecules in various physiological and pathological processes.A myriad of studies have shown that abnormal levels of sphing...
关键词:SPHINGOLIPIDS CERAMIDE Therapeutic targets MICRODOMAIN Biomarker 
Cellular Lipidome Changes during Retinoic Acid(RA)-Induced Differentiation in SH-SY5Y Cells:A Comprehensive In Vitro Model for Assessing Neurotoxicity of Contaminants
《Environment & Health》2023年第2期110-120,共11页Michelle Camdzic Diana S.Aga G.Ekin Atilla-Gokcumen 
the support from the National Science Foundation(CBET-2112201)。
The SH-SY5Y,neuroblastoma cell line,is a common in vitro model used to study physiological neuronal function and the neuronal response to different stimuli,including exposure to toxic chemicals.These cells can be diff...
关键词:LIPIDOMICS SH-SY5Y differentiation TRIACYLGLYCERIDES PHOSPHOLIPIDS SPHINGOLIPIDS STEROLS 
Lipidomics approach in alcoholic liver disease mice with sphingolipid metabolism disorder:Alleviation using sea cucumber phospholipids
《Food Bioscience》2023年第3期1127-1136,共10页Zhigao Wang Xiaoxu Wang Yuliu Wang Yanjun Liu Xincen Wang Yu Song Jie Xu Changhu Xue 
financed by the National Key R&D Program of China(No.2018YFC0311201);the Fundamental Research Funds for the Central Universities of China(No.202012018).
The sea cucumber phospholipids(SC-PLs)are involved in regulating multiple chronic lipid metabolism disorders,but their mechanism remains unknown.Herein,ethanol diet-induced C57BL/6N mice were established as alcoholic ...
关键词:Sea cucumber phospholipids Alcoholic liver disease Lipid metabolism disorder SPHINGOLIPIDS LC-MS/MS 
Phosphorylation of the LCB1 subunit of Arabidopsis serine palmitoyltransferase stimulates its activity and modulates sphingolipid biosynthesis
《Journal of Integrative Plant Biology》2023年第6期1585-1601,共17页Yuan Li Hanwei Cao Tingting Dong Xiaoke Wang Liang Ma Kun Li Huiqiang Lou Chun-Peng Song Dongtao Ren 
supported by grants from the National Natural Science Foundation of China(grant no.31970276 and grant no.32270271)to D.R。
Sphingolipids are the structural components of membrane lipid bilayers and act as signaling molecules in many cellular processes.Serine palmitoyltransferase(SPT)is the first committed and rate-limiting enzyme in the d...
关键词:ARABIDOPSIS MAPK PHOSPHORYLATION SPHINGOLIPIDS 
Nonalcoholic steatohepatitis critically rewires the ischemia/ reperfusion-induced dysregulation of cardiolipins and sphingolipids in mice被引量:2
《Hepatobiliary Surgery and Nutrition》2023年第1期3-19,I0001,I0002,共19页Sheng Yu Kai Wang Qingping Li Yiran Wei Yiyi Li Qifan Zhang Pengxiang Huang Hanbiao Liang Hang Sun Hongxian Peng Xixin Huang Cuiting Liu Jie Zhou Jianping Qian Chuanjiang Li 
This work was supported by the National Natural Science Foundation of China(No.82070642)to JZ;the Guangdong Province Science and Technology Program(No.2020A1515011205)to KW;the Guangdong Province Science and Technology Program(No.2021A1515012146)to CJL;the President Foundation of Nanfang Hospital,Southern Medical University(No.2018C029)to JPQ.
Background:Lipid dysregulation plays a fundamental role in nonalcoholic steatohepatitis(NASH),which is an emerging critical risk factor that aggravates hepatic ischemia/reperfusion(I/R)injury.However,the specific lipi...
关键词:Nonalcoholic steatohepatitis(NASH) ischemia/reperfusion injury LIPIDOMICS lipid metabolism 
Quantitative Determination of Sphingolipids by HPLC-ESI/MSn
《Agricultural Biotechnology》2022年第5期134-135,139,共3页Jin XIE Rong SONG Li ZHOU Siwen PENG Yanning HUANG Xiaoqi ZHU 
Supported by Science and Technology Innovation Project of Hunan Academy of Agricultural Sciences (2021CX32)。
The most predominant sphingoilipids bases are phytosphingosine(phyto-sph) and phytosphingosine-1-phosphate(phyto-S1 P), followed by dihydrosphingosine(dh-sph) and dihydroshingosine-1-phosphate(dh-S1 P). In this study,...
关键词:Sphingoilipids Liquid chromatography Mass spectrometry 
Bile acids and sphingolipids in non-alcoholic fatty liver disease被引量:4
《Chinese Medical Journal》2022年第10期1163-1171,共9页Kaitlyn G.Jackson Grayson W.Way Huiping Zhou 
This study was supported by Department of Veteran Affairs Merit Award(No. I01BX004033);Research Career Scientist Award(No. IK6BX0094477);National Institutes of Health Grant(Nos. R01 DK104893, R01DK-057543, and R21 AA026629-01)。
Non-alcoholic fatty liver disease (NAFLD) is one of the fastest-growing diseases, and its global prevalence is estimated to increase >50% by 2030. NAFLD is comorbid with metabolic syndrome, obesity, type 2 diabetes, a...
关键词:Bile acids SPHINGOLIPIDS Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis 
Deciphering lipid dysregulation in ALS:from mechanisms to translational medicine
《Translational Neurodegeneration》2022年第1期192-218,共27页Ira Agrawal Yong Shan Lim Shi-Yan Ng Shuo-Chien Ling 
National Medical Research Council(NMRC/OFIRG/0042/2017);National Research Foundation(NRF2019-NRF-ISF003-3221);Ministry of Education(MOE-T2EP30220-0029),Singapore to S.-C.L.
Lipids,defined by low solubility in water and high solubility in nonpolar solvents,can be classified into fatty acids,glycerolipids,glycerophospholipids,sphingolipids,and sterols.Lipids not only regulate integrity and...
关键词:Amyotrophic lateral sclerosis SPHINGOLIPIDS TRIGLYCERIDES Phospholipids Cholesterol esters Fatty acids CERAMIDES Arachidonic acid LYSOPHOSPHATIDYLCHOLINE EICOSANOIDS 
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