ADENINE

作品数：118被引量：219H指数：8
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相关领域：医药卫生理学更多>>
相关作者：吴文莉马威刘毅陈刚刘海英更多>>
相关机构：中国医学科学院北京协和医学院武汉市第一医院辽宁大学济南大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划天津市自然科学基金中国博士后科学基金更多>>
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Modulatory effects of Lactiplantibacillus plantarum MA2 and its postbiotic on the adenine-induced chronic kidney disease
《Food Science and Human Wellness》2025年第1期262-270,共9页Weitao Geng Dehua Wang Jiangye He Xinyuan Li Longgang Jia Yanping Wang 
financially supported by the National Natural Science Foundation of China(31801514);China Postdoctoral Science Foundation(2020M680895)。
Chronic kidney disease(CKD)is one kind of illness with abnormal renal structure and function caused by many factors.Probiotics can be used to regulate intestinal microflora and enhance intestinal mucosal barrier,thus,...
关键词：Chronic kidney disease Lactiplantibacillus plantarum Postbiotic Uremic toxin Gut microbiota 
Role of sphingolipid metabolism signaling in a novel mouse model of renal osteodystrophy based on transcriptomic approach
《Chinese Medical Journal》2025年第1期68-78,共11页Yujia Wang Yan Di Yongqi Li Jing Lu Bofan Ji Yuxia Zhang Zhiqing Chen Sijie Chen Bicheng Liu Rining Tang 
funded by the National Natural Science Foundation of China(No.82370742);the Key Program of Jiangsu Health and Health Committee(No.ZD2022045).
Background:Renal osteodystrophy(ROD)is a skeletal pathology associated with chronic kidney disease-mineral and bone disorder(CKD-MBD)that is characterized by aberrant bone mineralization and remodeling.ROD increases t...
关键词：Chronic kidney disease-mineral and bone disorder Renal osteodystrophy ADENINE PHOSPHATE TRANSCRIPTOMICS SPHINGOLIPIDS 
Establishment of abdominal aortocaval fistula in adenine-induced renal failure rats
《China Medical Abstracts(Internal Medicine)》2024年第2期115-116,共2页张艺斐 
Objective To explore the construction of abdominal aortocaval fistula(ACF)model in adenine-induced renal failure rats,and to provide a suitable animal model for subsequent mechanism and intervention researches.Methods...
关键词：RATS FISTULA RENAL 
Boosting genome editing in plants with single transcript unit surrogate reporter systems被引量：1
《Plant Communications》2024年第6期32-43,共12页Xu Tang Qiurong Ren Xiaodan Yan Rui Zhang Li Liu Qinqin Han Xuelian Zheng Yiping Qi Hongyuan Song Yong Zhang 
supported by the National Key Research and Development Program of China(award no.2023YFD1202900);the National Science Foundation of China(award nos.32270433 and 32101205);the Natural Science Foundation of Sichuan Province(award no.2022NSFSC0143)to Y.Z.and X.T.,the Joint Science and Technology Project between Sichuan Province and Chongqing Municipality(award no.CSTC2021JSCXCYLHX0001)to H.S.and X.T.;the Modern Seed Industry Project of Chongqing Municipal Science and Technology Bureau(award no.CSTB2023TIAD-KPX0025)to H.S.;the National Science Foundation of China(award no.32301248)to Q.R.;the National Science Foundation of China(award no.32072045)to X.Z.;supported by the NSF Plant Genome Research Program(award nos.IOS-2029889 and IOS-2132693)to Y.Q.
CRISPR-Cas-based genome editing holds immense promise for advancing plant genomics and crop enhancement.However,the challenge of low editing activity complicates the identification of editing events.In this study,we i...
关键词：CRISPR-Cas9 single transcript unit STU surrogate reporter SR single strand annealing SSA cyto-sine base editing adenine base editing 
Targeted DNA N^(6)-methyladenine editing by dCas9 fused to METTL4 in the lepidopteran model insect Bombyx mori
《Insect Science》2024年第2期646-650,共5页Feng Chen Hao Guo Weiqun Lan Mingyi Zhou Wenjng Geng Guanwang Shen Ping Lin Qingyou Xia Ping Zhao Zhiqing Li 
supported by National Key Research and Development Program of China(No.2022YFD1201600);National Natural Science Foundation of China(Nos.32030103 and 32172798);Natural Science Foundation of Chongqing(No.cstc2020jcyj-cxttX0001).
Dear Editor,N^(6)-Methyladenine(6mA)DNA modification is an important epigenetic mechanism with roles in regulating gene expression,nucleosome positioning,DNA damage repair,and cell cycle progression(Heyn&Esteller,2015...
关键词：ADENINE FUSED Bombyx 
Genome-wide adenine N6-methylation map reveals epigenomic regulation of lipid accumulation in Nannochloropsis
《Plant Communications》2024年第3期106-122,共17页Yanhai Gong Qintao Wang Li Wei Wensi Liang Lianhong Wang Nana Lv Xuefeng Du Jiashun Zhang Chen Shen Yi Xin Luyang Sun Jian Xu 
supported by the Synthetic Biology Program of the Ministry of Science and Technology of the People’s Republic of China (2021YFA0909700);I201908 and E1551402 from the Qingdao Institute of Bioenergy and Bioprocess Technology,Chinese Academy of Sciences,31900071 from the Natural Science Foundation of China;ZR2019QC012 from the Natural Science Foundation of Shandong Province.
Epigenetic marks on histones and DNA,such as DNA methylation at N6-adenine(6mA),play crucial roles in gene expression and genome maintenance,but their deposition and function in microalgae remain largely uncharacteriz...
关键词：adenine N6-methylation industrial oleaginous microalgae Nannochloropsis oceanica transcriptional regulation EPIGENOMICS 
Development of a cell-permeable adenine-derived probe for capture of nucleotide-binding proteins in living cells
《Chinese Chemical Letters》2024年第3期243-246,共4页Lihong Liu Rui Chen Gang Xue Chenzhou Hao Weizhi Weng Zhengying Pan 
funding support from the National Natural Science Foundation of China(No.81872749);Shenzhen Science and Technology Innovation Commission(Nos.20200815000631001 and JCYJ20200109120414564);Peking University。
Adenine is an essential building block of genetic material and a range of coenzymes.Chemical probes containing an adenine moiety have been used in kinase profiling studies in cell lysates.Here we report that adenine-d...
关键词：Adenine-derived probe Cell-permeable Lysine residue Protein kinases Nucleotide-binding proteins 
Correction of a CADASIL point mutation using adenine base editors in hiPsCsandbloodvessel organoids被引量：1
《Journal of Genetics and Genomics》2024年第2期197-207,共11页Jingwen Wang Lei Zhang Guanglan Wu Jinni Wu Xinyao Zhou Xiaolin Chen Yongxia Niu Yiren Jiao Qianyi Liu Puping Liang Guang Shi Xueqing Wu Junjiu Huang 
funded by the National Natural Science Foundation of China(31971365);the Guangdong Basic and Applied Basic Research Foundation(2020B1515120090);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2019BT02Y276).
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic small vessel disease caused by mutations in the NOTCH3 gene. However, the pathogenesis of CADASIL rem...
关键词：CADASIL Induced pluripotent stem cells Adenine base editors AAV Blood vessel Organoid 
Effects of Etelcalcetide on Bone Microstructure in the Adenine-Induced Chronic Kidney Disease Rat Model
《Open Journal of Orthopedics》2023年第12期509-524,共16页Shun Igarashi Yuji Kasukawa Koji Nozaka Hiroyuki Tsuchie Kazunobu Abe Hikaru Saito Ryo Shoji Fumihito Kasama Shuntaro Harata Kento Okamoto Keita Oya Naohisa Miyakoshi 
Objective: Chronic kidney disease (CKD) with secondary hyperparathyroidism (SHPT) increases the risk of fragility fractures with deterioration of cortical and trabecular bone microstructure. Etelcalcetide (EC), which ...
关键词：Chronic Kidney Disease Secondary Hyperparathyroidism OSTEOPOROSIS Etelcalcetide 
Adenine base editor incorporating the N-methylpurine DNA glycosylase MPGv3 enables efficient A-to-K base editing in rice被引量：7
《Plant Communications》2023年第6期230-233,共4页Xuemei Wu Bin Ren Lang Liu Shengqun Qiu Xin’ge Li Peijing Li Fang Yan Honghui Lin Xueping Zhou Dawei Zhang Huanbin Zhou 
supported by the Hainan Yazhou Bay Seed Lab(B21HJ0215);the Key Laboratory of Gene Editing Technologies(Hainan)of the Ministry of Agriculture and Rural Affairs,China,and the Agricultural Science and Technology Innovation Program of the Chinese Academy of Agricultural Sciences to H.Z.and the Central Public-interest Scientific Institution Basal Research Fund(Y2022PT24)to F.Y.
Dear Editor,Crop genetic diversity and elite agronomic traits are mainly caused by genetic variants,approximately half of which are single-nucleotide polymorphisms.Precise nucleotide substitution through CRISPR–Cas-m...
关键词：ELITE BASE EDITOR 
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