Targeted DNA N^(6)-methyladenine editing by dCas9 fused to METTL4 in the lepidopteran model insect Bombyx mori  

作　　者：Feng Chen Hao Guo Weiqun Lan Mingyi Zhou Wenjng Geng Guanwang Shen Ping Lin Qingyou Xia Ping Zhao Zhiqing Li 

机构地区：[1]Integrative Science Center of Germplasm Creation in Western China(CHONGQING)Science City,Biological Science Research Center,Southwest University,Chongqing,China [2]Chongqing Key Laboratory of Sericultural Science,Chongqing Engineering and Technology Research Center for Novel Silk Materials,Southwest University,Chongqing,China

出　　处：《Insect Science》2024年第2期646-650,共5页昆虫科学（英文版）

基　　金：supported by National Key Research and Development Program of China(No.2022YFD1201600);National Natural Science Foundation of China(Nos.32030103 and 32172798);Natural Science Foundation of Chongqing(No.cstc2020jcyj-cxttX0001).

摘　　要：Dear Editor,N^(6)-Methyladenine(6mA)DNA modification is an important epigenetic mechanism with roles in regulating gene expression,nucleosome positioning,DNA damage repair,and cell cycle progression(Heyn&Esteller,2015;Luo et al.,2015;Boulias&Greer,2022).Despite progress in understanding the biological functions of 6mA,the contribution of individual 6mA installations on site-specific target genes is largely unknown,and therefore deciphering the molecular mechanism of 6mA in target gene expression has been difficult.

关 键 词：ADENINE FUSED Bombyx 

分 类 号：Q96[生物学—昆虫学]