EPIGENOMICS

作品数：38被引量：117H指数：7
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相关机构：香港中文大学同济大学更多>>
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Opportunities and Challenges in Advancing Plant Research with Single-cell Omics被引量：1
《Genomics, Proteomics & Bioinformatics》2024年第2期13-26,共14页Mohammad Saidur Rhaman Muhammad Ali Wenxiu Ye Bosheng Li 
supported by the National Natural Science Foundation of China(Grant No.32170574);the start-up fund of Peking University Institute of Advanced Agricultural Sciences,the Shandong Laboratory of Advanced Agricultural Sciences,the National Key R&D of China(Grant No.2018YFA0507101);the Program for Guangdong Introducing Innovative and Entrepreneurial Teams(Grant No.2016ZT06S172);the Taishan Scholars Program;the Yuandu Scholars Program,China.
Plants possess diverse cell types and intricate regulatory mechanisms to adapt to the ever-changing environment of nature.Various strategies have been employed to study cell types and their developmental progressions,...
关键词：Multi-omics Single-cell transcriptomics Spatial transcriptomics Single-cell epigenomics Single-cell proteomics 
Omics approaches in asthma research:Challenges and opportunities
《Chinese Medical Journal Pulmonary and Critical Care Medicine》2024年第1期1-9,共9页Molin Yue Shiyue Tao Kristina Gaietto Wei Chen 
Asthma,a chronic respiratory disease with a global prevalence of approximately 300 million individuals,presents a significant societal and economic burden.This multifaceted syndrome exhibits diverse clinical phenotype...
关键词：Asthma Genomics TRANSCRIPTOMICS EPIGENOMICS METAGENOMICS Multi-omics integration 
Genome-wide adenine N6-methylation map reveals epigenomic regulation of lipid accumulation in Nannochloropsis
《Plant Communications》2024年第3期106-122,共17页Yanhai Gong Qintao Wang Li Wei Wensi Liang Lianhong Wang Nana Lv Xuefeng Du Jiashun Zhang Chen Shen Yi Xin Luyang Sun Jian Xu 
supported by the Synthetic Biology Program of the Ministry of Science and Technology of the People’s Republic of China (2021YFA0909700);I201908 and E1551402 from the Qingdao Institute of Bioenergy and Bioprocess Technology,Chinese Academy of Sciences,31900071 from the Natural Science Foundation of China;ZR2019QC012 from the Natural Science Foundation of Shandong Province.
Epigenetic marks on histones and DNA,such as DNA methylation at N6-adenine(6mA),play crucial roles in gene expression and genome maintenance,but their deposition and function in microalgae remain largely uncharacteriz...
关键词：adenine N6-methylation industrial oleaginous microalgae Nannochloropsis oceanica transcriptional regulation EPIGENOMICS 
Leveraging genomics,transcriptomics and epigenomics to understand chemoimmunotherapy resistance in chronic lymphocytic leukemia
《Cancer Drug Resistance》2024年第1期956-966,共11页Shin Yeu Ong Lili Wang 
Patients with chronic lymphocytic leukemia(CLL)have differing clinical outcomes.Recent advances integrating multi-omic data have uncovered molecular subtypes in CLL with different prognostic implications and may allow...
关键词：Chronic lymphocytic leukemia CHEMOIMMUNOTHERAPY RESISTANCE 
GametesOmics:A Comprehensive Multi-omics Database for Exploring the Gametogenesis in Humans and Mice
《Genomics, Proteomics & Bioinformatics》2024年第1期121-130,共10页Jianting An Jing Wang Siming Kong Shi Song Wei Chen Peng Yuan Qilong He Yidong Chen Ye Li Yi Yang Wei Wang Rong Li Liying Yan Zhiqiang Yan Jie Qiao 
supported by the National Natural Science Foundation of China(Grant Nos.82125013 and 82101741);the National Key R&D Program of China(Grant No.2019YFA0801400);the Beijing Natural Science Foundation,China(Grant No.7232203);The authors thank Professor Fan Guo for providing detailed information about their previous study and Doctors Tong Chen and Pu Xue(EHBIO Gene Technology)for their technical assistance.
Gametogenesis plays an important role in the reproduction and evolution of species.The transcriptomic and epigenetic alterations in this process can influence the reproductive capacity,fertilization,and embryonic deve...
关键词：GAMETOGENESIS OOGENESIS SPERMATOGENESIS TRANSCRIPTOMICS EPIGENOMICS 
Nutritional epigenetics education improves diet and attitude of parents of children with autism or attention deficit/hyperactivity disorder
《World Journal of Psychiatry》2024年第1期159-178,共20页Renee J Dufault Katherine M Adler David O Carpenter Steven G Gilbert Raquel A Crider 
BACKGROUND Unhealthy maternal diet leads to heavy metal exposures from the consumption of ultra-processed foods that may impact gene behavior across generations,creating conditions for the neurodevelopmental disorders...
关键词：EPIGENOMICS Parenteral nutrition AUTISM Attention deficit/hyperactivity disorder Ultra-processed foods Heavy metals 
Non-small Cell Lung Cancer Epigenomes Exhibit Altered DNA Methylation in Smokers and Neversmokers
《Genomics, Proteomics & Bioinformatics》2023年第5期991-1013,共23页Jennifer A.Karlow Erica C.Pehrsson Xiaoyun Xing Mark Watson Siddhartha Devarakonda Ramaswamy Govindan Ting Wang 
supported in part by the Siteman Cancer Center Precision Medicine Pathway(Grant No.T32CA113275);Erica C.Pehrsson is supported by a Postdoctoral Fellowship from the American Cancer Society(Grant No.PF-17-201-01);Erica C.Pehrsson,Jennifer A.Karlow,and Ting Wang are supported by the National Institutes of Health[Grant Nos.R01HG007354(National Human Genome Research Institute);R01HG007175(National Human Genome Research Institute);R01ES024992(National Institute of Environmental Health Sciences);U01CA200060(National Cancer Institute);U24ES026699(National Institute of Environmental Health Sciences);U01HG009391(National Human Genome Research Institute)];the American Cancer Society(Grant No.RSG-14-049-01-DMC).
Epigenetic alterations are widespread in cancer and can complement genetic alterations to influence cancer progression and treatment outcome.To determine the potential contribution of DNA methylation alterations to tu...
关键词：Non-small cell lung cancer EPIGENOMICS M&M methylCRF DNA methylation 
Harnessing male germline epigenomics for the genetic improvement in cattle被引量：1
《Journal of Animal Science and Biotechnology》2023年第5期1834-1853,共20页Xiao Wang Wenlong Li Xia Feng Jianbin Li George E.Liu Lingzhao Fang Ying Yu 
funded by the National Key R&D Program of China(2021YFD1200903);Seed Fund(CAU),Shandong Provincial Natural Science Foundation(ZR2021MC070);the National Key R&D Program of China(2021YFF1000701-06);Shandong Provincial Natural Science Foundation(ZR2020MC165);the Earmarked Fund for CARS-36.X.W.is funded by the“Hundred Talents Program”project of Hebei Province(E2020100019);the research project of Zhongnongtongchuang(ZNTC)group(ZNTC2019A10 and ZNTC2021B12)in China.
Sperm is essential for successful artificial insemination in dairy cattle,and its quality can be influenced by both epi-genetic modification and epigenetic inheritance.The bovine germline differentiation is characteri...
关键词：Artificial insemination CATTLE Epigenetic inheritance Genetic improvement Germline epigenomics 
Single-cell protein-DNA interactomics and multiomics tools for deciphering genome regulation
《National Science Open》2023年第3期64-82,共19页Haiqing Xiong Runyu Wang Aibin He 
supported by the National Key Research and Development Program of China(2021YFA1100101 and 2017YFA0103402);the National Natural Science Foundation of China(32025015 and 31771607);the Peking-Tsinghua Center for Life Sciences.
The emergence of single-cell genomic and transcriptomic sequencing accelerates the development of single-cell epigenomic technologies,providing an unprecedented opportunity for decoding cell fate decisions largely enc...
关键词：single-cell protein-DNA interaction single-cell multiomics single-cell epigenomics epigenome genome regulation 
Accurate Identification of DNA Replication Origin by Fusing Epigenomics and Chromatin Interaction Information被引量：1
《Research》2023年第1期455-468,共14页Fu-Ying Dao Hao Lv Melissa J.Fullwood Hao Lin 
supported by a grant from the National Natural Science Foundation of China(62172078);the Science Fund for Distinguished Young Scholars of Sichuan Province(20JCQN0262);supported by an Singapore Ministry of Education Tier I(grant R86/21)awarded to Melissa J.Fullwood;supported by the China Scholarship Council to visit Nanyang Technological University.
DNA replication initiation is a complex process involving various genetic and epigenomic signatures.The correct identification of replication origins(ORIs)could provide important clues for the study of a variety of di...
关键词：REPLICATION SIGNATURE ORIGIN 
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