GametesOmics:A Comprehensive Multi-omics Database for Exploring the Gametogenesis in Humans and Mice  

作　　者：Jianting An Jing Wang Siming Kong Shi Song Wei Chen Peng Yuan Qilong He Yidong Chen Ye Li Yi Yang Wei Wang Rong Li Liying Yan Zhiqiang Yan Jie Qiao 

机构地区：[1]State Key Laboratory of Female Fertility Promotion,Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Peking University Third Hospital,Beijing 100191,China [2]National Clinical Research Center for Obstetrics and Gynecology,Peking University Third Hospital,Beijing 100191,China [3]Key Laboratory of Assisted Reproduction,Ministry of Education,Peking University,Beijing 100191,China [4]Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology,Beijing 100191,China [5]Peking-Tsinghua Center for Life Sciences,Peking University,Beijing 100871,China [6]Beijing Advanced Innovation Center for Genomics,Beijing 100191,China

出　　处：《Genomics, Proteomics & Bioinformatics》2024年第1期121-130,共10页基因组蛋白质组与生物信息学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.82125013 and 82101741);the National Key R&D Program of China(Grant No.2019YFA0801400);the Beijing Natural Science Foundation,China(Grant No.7232203);The authors thank Professor Fan Guo for providing detailed information about their previous study and Doctors Tong Chen and Pu Xue(EHBIO Gene Technology)for their technical assistance.

摘　　要：Gametogenesis plays an important role in the reproduction and evolution of species.The transcriptomic and epigenetic alterations in this process can influence the reproductive capacity,fertilization,and embryonic development.The rapidly increasing single-cell studies have provided valuable multi-omics resources.However,data from different layers and sequencing platforms have not been uniformed and integrated,which greatly limits their use for exploring the molecular mechanisms that underlie oogenesis and spermatogenesis.Here,we develop GametesOmics,a comprehensive database that integrates the data of gene expression,DNA methylation,and chromatin accessibility during oogenesis and spermatogenesis in humans and mice.GametesOmics provides a user-friendly website and various tools,including Search and Advanced Search for querying the expression and epigenetic modification(s)of each gene;Tools with Differentially expressed gene(DEG)analysis for identifying DEGs,Correlation analysis for demonstrating the genetic and epigenetic changes,Visualization for displaying single-cell clusters and screening marker genes as well as master transcription factors(TFs),and MethylView for studying the genomic distribution of epigenetic modifications.GametesOmics also provides Genome Browser and Ortholog for tracking and comparing gene expression,DNA methylation,and chromatin accessibility between humans and mice.GametesOmics offers a comprehensive resource for biologists and clinicians to decipher the cell fate transition in germ cell development,and can be accessed at http://gametesomics.cn/.

关 键 词：GAMETOGENESIS OOGENESIS SPERMATOGENESIS TRANSCRIPTOMICS EPIGENOMICS 

分 类 号：Q78[生物学—分子生物学]