supported by the National Natural Science Foundation of China(32121001,32201213)。
Among over 170 different types of chemical modifications on RNA nucleobases identified so far,RNA methylation is the major type of epitranscriptomic modifications existing on almost all types of RNAs,and has been demo...
The specification of germ cells in zebrafish mostly relies on an inherited mechanism by which localized maternal determinants,called germ plasm,confer germline fate in the early embryo.Extensive studies have partially...
supported by the National Natural Science Foundation of China(Grant No.82071614 to Huifen Xiang and Grant No.82101783 to Zuying Xu);the National Key R&D Program of China(Grant No.2021YFC2700600);the Anhui Medical University School Fund(Grant No.2020xkj182)。
The most common epigenetic modification of messenger RNAs(mRNAs)is N^(6)-methyladenosine(m^(6)A),which is mainly located near the 30 untranslated region of mRNAs,near the stop codons,and within internal exons.The biol...
supported by the National Natural Science Foundation of China(32270450,32071449);Shanxi Key Program International S&T Cooperation Projects(202104041101011);Shanxi Scholarship Council of China(2020016).
Histone modification and nucleosome assembly play important roles in chromatin-related processes.Histone chaperones form different complexes and coordinate histone transportation and assembly.Various histone chaperone...
supported by the National Natural Science Foundation of China(Grant Nos.82125013 and 82101741);the National Key R&D Program of China(Grant No.2019YFA0801400);the Beijing Natural Science Foundation,China(Grant No.7232203);The authors thank Professor Fan Guo for providing detailed information about their previous study and Doctors Tong Chen and Pu Xue(EHBIO Gene Technology)for their technical assistance.
Gametogenesis plays an important role in the reproduction and evolution of species.The transcriptomic and epigenetic alterations in this process can influence the reproductive capacity,fertilization,and embryonic deve...
supported by an academic grant from Repro Optima Center for Reproductive Health,Inc.
In vitro gametogenesis(IVG)has been a topic of great interest in recent years not only because it allows for further exploration of mechanisms of germ cell development,but also because of its prospect for innovative m...
supported by grants from the National Natural Science Foundation of China(31530072,31830093,31601903,32102611);the Natural Science Foundation of Jiangsu Province(BK20210880).
As a defense mechanism against transposable elements,the PIWI-interacting RNA(piRNA)pathway maintains genomic integrity and ensures proper gametogenesis in gonads.Numerous factors are orchestrated to ensure normal ope...
financially supported by the National Key R&D Program of China(Nos.2018YFD0900305,2018YFD 0901500);the China Agriculture Research System of MOF and MARA,Central Public-interest Scientific Institution Basal Research Fund CAFS(No.2020TD27);the‘Young Talent of Fishery Sciences’project from Laboratory for Marine Fisheries and Aquaculture(No.2018-MFS-T12).
Saccharina japonica gametophytes can survive a long period under unfavorable environmental conditions,while they also delay in growth and/or reproduction.Although the reproduction in delayed gametophyte of S.japonica ...
supported by grants from the National Key R&D Program of China(2021YFC2700200);Academic Promotion Programme of Shandong First Medical University(2019U001);General Research Fund from Research Grants Council of Hong Kong(14103418);Basic Science Center Program of NFSC(31988101);the Shandong Provincial Key Research and Development Program(2020ZLYS02);a fund from A-Smart Group to support CUHKSDU Joint Laboratory on Reproductive Genetics of CUHK,Major Innovation Projects in Shandong Province(2021ZDSYS16);the Science Foundation for Distinguished Yong Scholars of Shandong(ZR2021JQ27);Taishan Scholars Program for Young Experts of Shandong Province(tsqn202103192).
RBM46 is a germ cell-specific RNA-binding protein required for gametogenesis,but the targets and molecular functions of RBM46 remain unknown.Here,we demonstrate that RBM46 binds at specific motifs in the 3'UTRs of mRN...
the Science and Engineering Research Board,New Delhi(CRG/2021/005588).
Vast stretches of open water bodies are gradually becoming hypoxic as a result of depletion of oxygen levels mainly due to various human anthropogenic activities.This problem of hypoxic stress on the fish population i...