Dynamic RNA methylation modifications and their regulatory role in mammalian development and diseases  

作　　者：Wenlan Yang Yongliang Zhao Yungui Yang 

机构地区：[1]State Key Laboratory of Reproductive Regulation&Breeding of Grassland Livestock,Inner Mongolia Key Laboratory for Molecular Regulation of the Cell,School of Life Sciences,Inner Mongolia University,Hohhot 010020,China [2]CAS Key Laboratory of Genomic and Precision Medicine,Beijing Institute of Genomics,Chinese Academy of Sciences,Beijing 100101,China [3]China National Center for Bioinformation,Beijing 100101,China [4]School of Future Technology,University of Chinese Academy of Sciences,Beijing 100049,China [5]Sino-Danish College,University of Chinese Academy of Sciences,Beijing 101408,China

出　　处：《Science China(Life Sciences)》2024年第10期2084-2104,共21页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(32121001,32201213)。

摘　　要：Among over 170 different types of chemical modifications on RNA nucleobases identified so far,RNA methylation is the major type of epitranscriptomic modifications existing on almost all types of RNAs,and has been demonstrated to participate in the entire process of RNA metabolism,including transcription,pre-mRNA alternative splicing and maturation,mRNA nucleus export,mRNA degradation and stabilization,mRNA translation.Attributing to the development of high-throughput detection technologies and the identification of both dynamic regulators and recognition proteins,mechanisms of RNA methylation modification in regulating the normal development of the organism as well as various disease occurrence and developmental abnormalities upon RNA methylation dysregulation have become increasingly clear.Here,we particularly focus on three types of RNA methylations:N^(6)-methylcytosine(m^(6)A),5-methylcytosine(m^(5)C),and N^(7)-methyladenosine(m^(7)G).We summarize the elements related to their dynamic installment and removal,specific binding proteins,and the development of high-throughput detection technologies.Then,for a comprehensive understanding of their biological significance,we also overview the latest knowledge on the underlying mechanisms and key roles of these three mRNA methylation modifications in gametogenesis,embryonic development,immune system development,as well as disease and tumor progression.

关 键 词：RNA methylation(m^(6)A m5C and m7G) detection techniques RNA metabolism GAMETOGENESIS EMBRYOGENESIS immune system development TUMORIGENESIS 

分 类 号：Q75[生物学—分子生物学]